Analysis of serious non-AIDS events among HIV-infected adults at Latin American sites
Objective: Acquired immune deficiency appears to be associated with serious non-AIDS (SNA)-defining conditions such as cardiovascular disease, liver and renal insufficiency and non-AIDS-related malignancies. We analysed the incidence of, and factors associated with, several SNA events in the LATINA...
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todo:paper_14642662_v11_n9_p554_Belloso2023-10-03T16:17:06Z Analysis of serious non-AIDS events among HIV-infected adults at Latin American sites Belloso, W.H. Orellana, L.C. Grinsztejn, B. Madero, J.S. La Rosa, A. Veloso, V.G. Sanchez, J. Ismerio Moreira, R. Crabtree-Ramirez, B. Garcia Messina, O. Lasala, M.B. Peinado, J. Losso, M.H. AIDS Cardiovascular disease CD4 cell lymphocyte count Cohort studies Liver diseases Neoplasms acute kidney failure adult alcohol abuse area under the curve article cardiovascular effect CD4 lymphocyte count cohort analysis controlled study diabetes mellitus female follow up hepatitis B hepatitis C human Human immunodeficiency virus infected patient incidence liver failure logistic regression analysis major clinical study male mixed infection priority journal retrospective study risk factor Acquired Immunodeficiency Syndrome Adult Anti-Retroviral Agents Cardiovascular Diseases CD4 Lymphocyte Count Epidemiologic Methods Female HIV Infections Humans Immunocompromised Host Liver Diseases Male Middle Aged Neoplasms Renal Insufficiency South America Objective: Acquired immune deficiency appears to be associated with serious non-AIDS (SNA)-defining conditions such as cardiovascular disease, liver and renal insufficiency and non-AIDS-related malignancies. We analysed the incidence of, and factors associated with, several SNA events in the LATINA retrospective cohort. Materials and methods: Cases of SNA events were recorded among cohort patients. Three controls were selected for each case from cohort members at risk. Conditional logistic models were fitted to estimate the effect of traditional risk factors as well as HIV-associated factors on non-AIDS-defining conditions. Results: Among 6007 patients in follow-up, 130 had an SNA event (0.86 events/100 person-years of follow-up) and were defined as cases (40 with cardiovascular events, 54 with serious liver failure, 35 with non-AIDS-defining malignancies and two with renal insufficiency). Risk factors such as diabetes, hepatitis B and C virus coinfections and alcohol abuse showed an association with events, as expected. The last recorded CD4 T-cell count prior to index date (P=0.0056, with an average difference of more than 100 cells/μL) and area under the CD4 cell curve in the year previous to index date (P=0.0081) were significantly lower in cases than in controls. CD4 cell count at index date was significantly associated with the outcome after adjusting for risk factors. Conclusions: The incidence and type of SNA events found in this Latin American cohort are similar to those reported in other regions. We found a significant association between immune deficiency and the risk of SNA events, even in patients under antiretroviral treatment. © 2010 British HIV Association. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_14642662_v11_n9_p554_Belloso |
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Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
AIDS Cardiovascular disease CD4 cell lymphocyte count Cohort studies Liver diseases Neoplasms acute kidney failure adult alcohol abuse area under the curve article cardiovascular effect CD4 lymphocyte count cohort analysis controlled study diabetes mellitus female follow up hepatitis B hepatitis C human Human immunodeficiency virus infected patient incidence liver failure logistic regression analysis major clinical study male mixed infection priority journal retrospective study risk factor Acquired Immunodeficiency Syndrome Adult Anti-Retroviral Agents Cardiovascular Diseases CD4 Lymphocyte Count Epidemiologic Methods Female HIV Infections Humans Immunocompromised Host Liver Diseases Male Middle Aged Neoplasms Renal Insufficiency South America |
| spellingShingle |
AIDS Cardiovascular disease CD4 cell lymphocyte count Cohort studies Liver diseases Neoplasms acute kidney failure adult alcohol abuse area under the curve article cardiovascular effect CD4 lymphocyte count cohort analysis controlled study diabetes mellitus female follow up hepatitis B hepatitis C human Human immunodeficiency virus infected patient incidence liver failure logistic regression analysis major clinical study male mixed infection priority journal retrospective study risk factor Acquired Immunodeficiency Syndrome Adult Anti-Retroviral Agents Cardiovascular Diseases CD4 Lymphocyte Count Epidemiologic Methods Female HIV Infections Humans Immunocompromised Host Liver Diseases Male Middle Aged Neoplasms Renal Insufficiency South America Belloso, W.H. Orellana, L.C. Grinsztejn, B. Madero, J.S. La Rosa, A. Veloso, V.G. Sanchez, J. Ismerio Moreira, R. Crabtree-Ramirez, B. Garcia Messina, O. Lasala, M.B. Peinado, J. Losso, M.H. Analysis of serious non-AIDS events among HIV-infected adults at Latin American sites |
| topic_facet |
AIDS Cardiovascular disease CD4 cell lymphocyte count Cohort studies Liver diseases Neoplasms acute kidney failure adult alcohol abuse area under the curve article cardiovascular effect CD4 lymphocyte count cohort analysis controlled study diabetes mellitus female follow up hepatitis B hepatitis C human Human immunodeficiency virus infected patient incidence liver failure logistic regression analysis major clinical study male mixed infection priority journal retrospective study risk factor Acquired Immunodeficiency Syndrome Adult Anti-Retroviral Agents Cardiovascular Diseases CD4 Lymphocyte Count Epidemiologic Methods Female HIV Infections Humans Immunocompromised Host Liver Diseases Male Middle Aged Neoplasms Renal Insufficiency South America |
| description |
Objective: Acquired immune deficiency appears to be associated with serious non-AIDS (SNA)-defining conditions such as cardiovascular disease, liver and renal insufficiency and non-AIDS-related malignancies. We analysed the incidence of, and factors associated with, several SNA events in the LATINA retrospective cohort. Materials and methods: Cases of SNA events were recorded among cohort patients. Three controls were selected for each case from cohort members at risk. Conditional logistic models were fitted to estimate the effect of traditional risk factors as well as HIV-associated factors on non-AIDS-defining conditions. Results: Among 6007 patients in follow-up, 130 had an SNA event (0.86 events/100 person-years of follow-up) and were defined as cases (40 with cardiovascular events, 54 with serious liver failure, 35 with non-AIDS-defining malignancies and two with renal insufficiency). Risk factors such as diabetes, hepatitis B and C virus coinfections and alcohol abuse showed an association with events, as expected. The last recorded CD4 T-cell count prior to index date (P=0.0056, with an average difference of more than 100 cells/μL) and area under the CD4 cell curve in the year previous to index date (P=0.0081) were significantly lower in cases than in controls. CD4 cell count at index date was significantly associated with the outcome after adjusting for risk factors. Conclusions: The incidence and type of SNA events found in this Latin American cohort are similar to those reported in other regions. We found a significant association between immune deficiency and the risk of SNA events, even in patients under antiretroviral treatment. © 2010 British HIV Association. |
| format |
JOUR |
| author |
Belloso, W.H. Orellana, L.C. Grinsztejn, B. Madero, J.S. La Rosa, A. Veloso, V.G. Sanchez, J. Ismerio Moreira, R. Crabtree-Ramirez, B. Garcia Messina, O. Lasala, M.B. Peinado, J. Losso, M.H. |
| author_facet |
Belloso, W.H. Orellana, L.C. Grinsztejn, B. Madero, J.S. La Rosa, A. Veloso, V.G. Sanchez, J. Ismerio Moreira, R. Crabtree-Ramirez, B. Garcia Messina, O. Lasala, M.B. Peinado, J. Losso, M.H. |
| author_sort |
Belloso, W.H. |
| title |
Analysis of serious non-AIDS events among HIV-infected adults at Latin American sites |
| title_short |
Analysis of serious non-AIDS events among HIV-infected adults at Latin American sites |
| title_full |
Analysis of serious non-AIDS events among HIV-infected adults at Latin American sites |
| title_fullStr |
Analysis of serious non-AIDS events among HIV-infected adults at Latin American sites |
| title_full_unstemmed |
Analysis of serious non-AIDS events among HIV-infected adults at Latin American sites |
| title_sort |
analysis of serious non-aids events among hiv-infected adults at latin american sites |
| url |
http://hdl.handle.net/20.500.12110/paper_14642662_v11_n9_p554_Belloso |
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