Synthesis of D-galactofuranose-containing molecules: design of galactofuranosyl acceptors.
D-Galactofuranose (D-Galf) is present in glycoconjugates of several pathogenic microorganisms but is absent in mammals, so it is a good target for the development of chemotherapeutic agents for the treatment of microbial infections. This fact has increased interest in the synthesis of D-Galf-contain...
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todo:paper_14397633_v15_n2_p188_Marino2023-10-03T16:16:19Z Synthesis of D-galactofuranose-containing molecules: design of galactofuranosyl acceptors. Marino, C. Baldoni, L. carbohydrate galactose glycoconjugate polysaccharide chemistry drug design galactofuranosides galactofuranosyl acceptors glycosylation methodology organic synthesis review synthesis carbohydrates galactofuranosides galactofuranosyl acceptors glycosylation organic synthesis Chemistry Techniques, Synthetic Drug Design Galactose Glycoconjugates Glycosylation Polysaccharides D-Galactofuranose (D-Galf) is present in glycoconjugates of several pathogenic microorganisms but is absent in mammals, so it is a good target for the development of chemotherapeutic agents for the treatment of microbial infections. This fact has increased interest in the synthesis of D-Galf-containing molecules for corresponding glycobiological studies. The synthesis of oligosaccharides, glycoconjugates, and mimetics of D-Galf requires specific methods for the preparation of galactose derivatives in the furanosic configuration, the synthesis of appropriate acceptors, and efficient glycosylation methods for the construction of α- and β-D-Galf linkages. This review summarizes the different strategies developed for the preparation of partially protected derivatives of D-Galf, suitable as acceptors for the construction of (1→2), (1→3), (1→5), and (1→6) link- ages, and describes recent applications. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Fil:Baldoni, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_14397633_v15_n2_p188_Marino |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
carbohydrate galactose glycoconjugate polysaccharide chemistry drug design galactofuranosides galactofuranosyl acceptors glycosylation methodology organic synthesis review synthesis carbohydrates galactofuranosides galactofuranosyl acceptors glycosylation organic synthesis Chemistry Techniques, Synthetic Drug Design Galactose Glycoconjugates Glycosylation Polysaccharides |
| spellingShingle |
carbohydrate galactose glycoconjugate polysaccharide chemistry drug design galactofuranosides galactofuranosyl acceptors glycosylation methodology organic synthesis review synthesis carbohydrates galactofuranosides galactofuranosyl acceptors glycosylation organic synthesis Chemistry Techniques, Synthetic Drug Design Galactose Glycoconjugates Glycosylation Polysaccharides Marino, C. Baldoni, L. Synthesis of D-galactofuranose-containing molecules: design of galactofuranosyl acceptors. |
| topic_facet |
carbohydrate galactose glycoconjugate polysaccharide chemistry drug design galactofuranosides galactofuranosyl acceptors glycosylation methodology organic synthesis review synthesis carbohydrates galactofuranosides galactofuranosyl acceptors glycosylation organic synthesis Chemistry Techniques, Synthetic Drug Design Galactose Glycoconjugates Glycosylation Polysaccharides |
| description |
D-Galactofuranose (D-Galf) is present in glycoconjugates of several pathogenic microorganisms but is absent in mammals, so it is a good target for the development of chemotherapeutic agents for the treatment of microbial infections. This fact has increased interest in the synthesis of D-Galf-containing molecules for corresponding glycobiological studies. The synthesis of oligosaccharides, glycoconjugates, and mimetics of D-Galf requires specific methods for the preparation of galactose derivatives in the furanosic configuration, the synthesis of appropriate acceptors, and efficient glycosylation methods for the construction of α- and β-D-Galf linkages. This review summarizes the different strategies developed for the preparation of partially protected derivatives of D-Galf, suitable as acceptors for the construction of (1→2), (1→3), (1→5), and (1→6) link- ages, and describes recent applications. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| format |
JOUR |
| author |
Marino, C. Baldoni, L. |
| author_facet |
Marino, C. Baldoni, L. |
| author_sort |
Marino, C. |
| title |
Synthesis of D-galactofuranose-containing molecules: design of galactofuranosyl acceptors. |
| title_short |
Synthesis of D-galactofuranose-containing molecules: design of galactofuranosyl acceptors. |
| title_full |
Synthesis of D-galactofuranose-containing molecules: design of galactofuranosyl acceptors. |
| title_fullStr |
Synthesis of D-galactofuranose-containing molecules: design of galactofuranosyl acceptors. |
| title_full_unstemmed |
Synthesis of D-galactofuranose-containing molecules: design of galactofuranosyl acceptors. |
| title_sort |
synthesis of d-galactofuranose-containing molecules: design of galactofuranosyl acceptors. |
| url |
http://hdl.handle.net/20.500.12110/paper_14397633_v15_n2_p188_Marino |
| work_keys_str_mv |
AT marinoc synthesisofdgalactofuranosecontainingmoleculesdesignofgalactofuranosylacceptors AT baldonil synthesisofdgalactofuranosecontainingmoleculesdesignofgalactofuranosylacceptors |
| _version_ |
1807318343117438976 |