Carrageenans from Sarcothalia crispata and Gigartina skottsbergii: Structural Analysis and Interpolyelectrolyte Complex Formation for Drug Controlled Release
The aims of the present study were to characterize for the first time the carrageenan extracted from cystocarpic stage of S. crispata collected in the Patagonian coast of Argentina, and to prepare interpolyelectrolytic complexes (IPECs) between the polysaccharide extracted from cystocarpic stage of...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_14362228_v20_n6_p706_Hughes |
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todo:paper_14362228_v20_n6_p706_Hughes2023-10-03T16:15:55Z Carrageenans from Sarcothalia crispata and Gigartina skottsbergii: Structural Analysis and Interpolyelectrolyte Complex Formation for Drug Controlled Release Hughes, M.H. Prado, H.J. Rodríguez, M.C. Michetti, K. Leonardi, P.I. Matulewicz, M.C. Carrageenan Controlled drug release Gigartina skottsbergii IPECs Sarcothalia crispata Drug products Scanning electron microscopy Targeted drug delivery Carrageenans Controlled drug release Gigartina skottsbergii IPECs Sarcothalia crispata Controlled drug delivery alga biotechnology drug plant extract polymer polysaccharide seaweed Argentina Patagonia Gigartina skottsbergii Sarcothalia crispata carrageenan methacrylic acid methyl ester chemical structure chemistry delayed release formulation red alga Carrageenan Delayed-Action Preparations Methylmethacrylates Molecular Structure Rhodophyta The aims of the present study were to characterize for the first time the carrageenan extracted from cystocarpic stage of S. crispata collected in the Patagonian coast of Argentina, and to prepare interpolyelectrolytic complexes (IPECs) between the polysaccharide extracted from cystocarpic stage of Sarcothalia crispata and Gigartina skottsbergii thalli, and basic butylated methacrylate copolymer (Eudragit E), in order to test their potential for the controlled release of ibuprofen as model drug. The structural determination revealed that the polysaccharides extracted from S. crispata and G. skottsbergii were mainly constituted by κ-carrageenan, particularly in the case of G. skottsbergii; however, significant amounts of ι- and ν-carrageenan were also detected in both polygalactans. The differences in diad composition and possibly in their distribution along the polysaccharide chain of both carrageenans would favor a different arrangement in the resulting IPEC structure. The smaller pores observed by scanning electron microscopy in the IPEC of S. crispata suggest that the kinks in the polysaccharide backbone are evenly distributed, resulting in a slower ibuprofen release compared to the IPEC of G. skottsbergii. © 2018, Springer Science+Business Media, LLC, part of Springer Nature. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_14362228_v20_n6_p706_Hughes |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Carrageenan Controlled drug release Gigartina skottsbergii IPECs Sarcothalia crispata Drug products Scanning electron microscopy Targeted drug delivery Carrageenans Controlled drug release Gigartina skottsbergii IPECs Sarcothalia crispata Controlled drug delivery alga biotechnology drug plant extract polymer polysaccharide seaweed Argentina Patagonia Gigartina skottsbergii Sarcothalia crispata carrageenan methacrylic acid methyl ester chemical structure chemistry delayed release formulation red alga Carrageenan Delayed-Action Preparations Methylmethacrylates Molecular Structure Rhodophyta |
| spellingShingle |
Carrageenan Controlled drug release Gigartina skottsbergii IPECs Sarcothalia crispata Drug products Scanning electron microscopy Targeted drug delivery Carrageenans Controlled drug release Gigartina skottsbergii IPECs Sarcothalia crispata Controlled drug delivery alga biotechnology drug plant extract polymer polysaccharide seaweed Argentina Patagonia Gigartina skottsbergii Sarcothalia crispata carrageenan methacrylic acid methyl ester chemical structure chemistry delayed release formulation red alga Carrageenan Delayed-Action Preparations Methylmethacrylates Molecular Structure Rhodophyta Hughes, M.H. Prado, H.J. Rodríguez, M.C. Michetti, K. Leonardi, P.I. Matulewicz, M.C. Carrageenans from Sarcothalia crispata and Gigartina skottsbergii: Structural Analysis and Interpolyelectrolyte Complex Formation for Drug Controlled Release |
| topic_facet |
Carrageenan Controlled drug release Gigartina skottsbergii IPECs Sarcothalia crispata Drug products Scanning electron microscopy Targeted drug delivery Carrageenans Controlled drug release Gigartina skottsbergii IPECs Sarcothalia crispata Controlled drug delivery alga biotechnology drug plant extract polymer polysaccharide seaweed Argentina Patagonia Gigartina skottsbergii Sarcothalia crispata carrageenan methacrylic acid methyl ester chemical structure chemistry delayed release formulation red alga Carrageenan Delayed-Action Preparations Methylmethacrylates Molecular Structure Rhodophyta |
| description |
The aims of the present study were to characterize for the first time the carrageenan extracted from cystocarpic stage of S. crispata collected in the Patagonian coast of Argentina, and to prepare interpolyelectrolytic complexes (IPECs) between the polysaccharide extracted from cystocarpic stage of Sarcothalia crispata and Gigartina skottsbergii thalli, and basic butylated methacrylate copolymer (Eudragit E), in order to test their potential for the controlled release of ibuprofen as model drug. The structural determination revealed that the polysaccharides extracted from S. crispata and G. skottsbergii were mainly constituted by κ-carrageenan, particularly in the case of G. skottsbergii; however, significant amounts of ι- and ν-carrageenan were also detected in both polygalactans. The differences in diad composition and possibly in their distribution along the polysaccharide chain of both carrageenans would favor a different arrangement in the resulting IPEC structure. The smaller pores observed by scanning electron microscopy in the IPEC of S. crispata suggest that the kinks in the polysaccharide backbone are evenly distributed, resulting in a slower ibuprofen release compared to the IPEC of G. skottsbergii. © 2018, Springer Science+Business Media, LLC, part of Springer Nature. |
| format |
JOUR |
| author |
Hughes, M.H. Prado, H.J. Rodríguez, M.C. Michetti, K. Leonardi, P.I. Matulewicz, M.C. |
| author_facet |
Hughes, M.H. Prado, H.J. Rodríguez, M.C. Michetti, K. Leonardi, P.I. Matulewicz, M.C. |
| author_sort |
Hughes, M.H. |
| title |
Carrageenans from Sarcothalia crispata and Gigartina skottsbergii: Structural Analysis and Interpolyelectrolyte Complex Formation for Drug Controlled Release |
| title_short |
Carrageenans from Sarcothalia crispata and Gigartina skottsbergii: Structural Analysis and Interpolyelectrolyte Complex Formation for Drug Controlled Release |
| title_full |
Carrageenans from Sarcothalia crispata and Gigartina skottsbergii: Structural Analysis and Interpolyelectrolyte Complex Formation for Drug Controlled Release |
| title_fullStr |
Carrageenans from Sarcothalia crispata and Gigartina skottsbergii: Structural Analysis and Interpolyelectrolyte Complex Formation for Drug Controlled Release |
| title_full_unstemmed |
Carrageenans from Sarcothalia crispata and Gigartina skottsbergii: Structural Analysis and Interpolyelectrolyte Complex Formation for Drug Controlled Release |
| title_sort |
carrageenans from sarcothalia crispata and gigartina skottsbergii: structural analysis and interpolyelectrolyte complex formation for drug controlled release |
| url |
http://hdl.handle.net/20.500.12110/paper_14362228_v20_n6_p706_Hughes |
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