Role of leptin in female reproduction

Reproductive function is dependent on energy resources. The role of weight, body composition, fat distribution and the effect of diet have been largely investigated in experimental female animals as well as in women. Any alteration in diet and/or weight may induce abnormalities in timing of sexual m...

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Autores principales:	Pérez-Pérez, A., Sánchez-Jiménez, F., Maymó, J., Dueñas, J.L., Varone, C., Sánchez-Margalet, V.
Formato:	JOUR
Materias:	infertility leptin reproduction estradiol gonadorelin gonadotropin leptin receptor matrix metalloproteinase STAT5 protein endocrine function female fetus development fetus growth gonadotropin release hormone action hormone release human hypophysis gonad system hypothalamus intracellular signaling lactation mouse nidation nonhuman obesity oocyte maturation ovary function placenta pregnancy protein function psychophysiology regulatory mechanism Review signal transduction animal gonadotropin secreting cell metabolism ovary physiology secretion (process) Animals Embryo Implantation Female Fetal Development Gonadotrophs Humans Leptin Ovary Pregnancy Reproduction
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_14346621_v53_n1_p15_PerezPerez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_14346621_v53_n1_p15_PerezPerez
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spelling	todo:paper_14346621_v53_n1_p15_PerezPerez2023-10-03T16:15:50Z Role of leptin in female reproduction Pérez-Pérez, A. Sánchez-Jiménez, F. Maymó, J. Dueñas, J.L. Varone, C. Sánchez-Margalet, V. infertility leptin reproduction estradiol gonadorelin gonadotropin leptin leptin receptor matrix metalloproteinase STAT5 protein leptin endocrine function female fetus development fetus growth gonadotropin release hormone action hormone release human hypophysis gonad system hypothalamus infertility intracellular signaling lactation mouse nidation nonhuman obesity oocyte maturation ovary function placenta pregnancy protein function psychophysiology regulatory mechanism reproduction Review signal transduction animal gonadotropin secreting cell metabolism ovary physiology secretion (process) Animals Embryo Implantation Female Fetal Development Gonadotrophs Humans Leptin Ovary Pregnancy Reproduction Reproductive function is dependent on energy resources. The role of weight, body composition, fat distribution and the effect of diet have been largely investigated in experimental female animals as well as in women. Any alteration in diet and/or weight may induce abnormalities in timing of sexual maturation and fertility. However, the cellular mechanisms involved in the fine coordination of energy balance and reproduction are largely unknown. The brain and hypothalamic structures receive endocrine and/or metabolic signals providing information on the nutritional status and the degree of fat stores. Adipose tissue acts both as a store of energy and as an active endocrine organ, secreting a large number of biologically important molecules termed adipokines. Adipokines have been shown to be involved in regulation of the reproductive functions. The first adipokine described was leptin. Extensive research over the last 10 years has shown that leptin is not only an adipose tissue-derived messenger of the amount of energy stores to the brain, but also a crucial hormone/cytokine for a number of diverse physiological processes, such as inflammation, angiogenesis, hematopoiesis, immune function, and most importantly, reproduction. Leptin plays an integral role in the normal physiology of the reproductive system with complex interactions at all levels of the hypothalamic-pituitary gonadal (HPG) axis. In addition, leptin is also produced by placenta, where it plays an important autocrine function. Observational studies have demonstrated that states of leptin excess, deficiency, or resistance can be associated with abnormal reproductive function. This review focuses on the leptin action in female reproduction. © De Gruyter 2015. Fil:Maymó, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Varone, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_14346621_v53_n1_p15_PerezPerez
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	infertility leptin reproduction estradiol gonadorelin gonadotropin leptin leptin receptor matrix metalloproteinase STAT5 protein leptin endocrine function female fetus development fetus growth gonadotropin release hormone action hormone release human hypophysis gonad system hypothalamus infertility intracellular signaling lactation mouse nidation nonhuman obesity oocyte maturation ovary function placenta pregnancy protein function psychophysiology regulatory mechanism reproduction Review signal transduction animal gonadotropin secreting cell metabolism ovary physiology secretion (process) Animals Embryo Implantation Female Fetal Development Gonadotrophs Humans Leptin Ovary Pregnancy Reproduction
spellingShingle	infertility leptin reproduction estradiol gonadorelin gonadotropin leptin leptin receptor matrix metalloproteinase STAT5 protein leptin endocrine function female fetus development fetus growth gonadotropin release hormone action hormone release human hypophysis gonad system hypothalamus infertility intracellular signaling lactation mouse nidation nonhuman obesity oocyte maturation ovary function placenta pregnancy protein function psychophysiology regulatory mechanism reproduction Review signal transduction animal gonadotropin secreting cell metabolism ovary physiology secretion (process) Animals Embryo Implantation Female Fetal Development Gonadotrophs Humans Leptin Ovary Pregnancy Reproduction Pérez-Pérez, A. Sánchez-Jiménez, F. Maymó, J. Dueñas, J.L. Varone, C. Sánchez-Margalet, V. Role of leptin in female reproduction
topic_facet	infertility leptin reproduction estradiol gonadorelin gonadotropin leptin leptin receptor matrix metalloproteinase STAT5 protein leptin endocrine function female fetus development fetus growth gonadotropin release hormone action hormone release human hypophysis gonad system hypothalamus infertility intracellular signaling lactation mouse nidation nonhuman obesity oocyte maturation ovary function placenta pregnancy protein function psychophysiology regulatory mechanism reproduction Review signal transduction animal gonadotropin secreting cell metabolism ovary physiology secretion (process) Animals Embryo Implantation Female Fetal Development Gonadotrophs Humans Leptin Ovary Pregnancy Reproduction
description	Reproductive function is dependent on energy resources. The role of weight, body composition, fat distribution and the effect of diet have been largely investigated in experimental female animals as well as in women. Any alteration in diet and/or weight may induce abnormalities in timing of sexual maturation and fertility. However, the cellular mechanisms involved in the fine coordination of energy balance and reproduction are largely unknown. The brain and hypothalamic structures receive endocrine and/or metabolic signals providing information on the nutritional status and the degree of fat stores. Adipose tissue acts both as a store of energy and as an active endocrine organ, secreting a large number of biologically important molecules termed adipokines. Adipokines have been shown to be involved in regulation of the reproductive functions. The first adipokine described was leptin. Extensive research over the last 10 years has shown that leptin is not only an adipose tissue-derived messenger of the amount of energy stores to the brain, but also a crucial hormone/cytokine for a number of diverse physiological processes, such as inflammation, angiogenesis, hematopoiesis, immune function, and most importantly, reproduction. Leptin plays an integral role in the normal physiology of the reproductive system with complex interactions at all levels of the hypothalamic-pituitary gonadal (HPG) axis. In addition, leptin is also produced by placenta, where it plays an important autocrine function. Observational studies have demonstrated that states of leptin excess, deficiency, or resistance can be associated with abnormal reproductive function. This review focuses on the leptin action in female reproduction. © De Gruyter 2015.
format	JOUR
author	Pérez-Pérez, A. Sánchez-Jiménez, F. Maymó, J. Dueñas, J.L. Varone, C. Sánchez-Margalet, V.
author_facet	Pérez-Pérez, A. Sánchez-Jiménez, F. Maymó, J. Dueñas, J.L. Varone, C. Sánchez-Margalet, V.
author_sort	Pérez-Pérez, A.
title	Role of leptin in female reproduction
title_short	Role of leptin in female reproduction
title_full	Role of leptin in female reproduction
title_fullStr	Role of leptin in female reproduction
title_full_unstemmed	Role of leptin in female reproduction
title_sort	role of leptin in female reproduction
url	http://hdl.handle.net/20.500.12110/paper_14346621_v53_n1_p15_PerezPerez
work_keys_str_mv	AT perezpereza roleofleptininfemalereproduction AT sanchezjimenezf roleofleptininfemalereproduction AT maymoj roleofleptininfemalereproduction AT duenasjl roleofleptininfemalereproduction AT varonec roleofleptininfemalereproduction AT sanchezmargaletv roleofleptininfemalereproduction
_version_	1807316505690374144

Role of leptin in female reproduction

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