Caged amino acids for visible-light photodelivery

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We present a photocleavable protecting group based on ruthenium bipyridyl complexes and suitable for amino acid photodelivery. We discuss the photochemical properties of the caged glutamate, which is a major neurotransmitter in the CNS. The molar absorptivity for the caged glutamate at 450 nm is ε =...

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Detalles Bibliográficos
Autores principales: Salierno, M., Fameli, C., Etchenique, R.
Formato: JOUR
Materias:
Caged compounds
Neurophysiology
Phototriggers
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_14341948_v_n7_p1125_Salierno
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_14341948_v_n7_p1125_Salierno
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spelling todo:paper_14341948_v_n7_p1125_Salierno2023-10-03T16:14:24Z Caged amino acids for visible-light photodelivery Salierno, M. Fameli, C. Etchenique, R. Caged compounds Neurophysiology Phototriggers We present a photocleavable protecting group based on ruthenium bipyridyl complexes and suitable for amino acid photodelivery. We discuss the photochemical properties of the caged glutamate, which is a major neurotransmitter in the CNS. The molar absorptivity for the caged glutamate at 450 nm is ε = 4200 M-1cm-1 and its quantum yield of photore-lease at 450 nm is ?̈PD = 0.035, which is about 17 times higher than that of the most active organic caged compound at this wavelength. Similar figures are obtained for other ?́-amino acids. © Wiley-VCH Verlag GmbH & Co. KGaA, 2008. Fil:Salierno, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Etchenique, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_14341948_v_n7_p1125_Salierno
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Caged compounds
Neurophysiology
Phototriggers
spellingShingle Caged compounds
Neurophysiology
Phototriggers
Salierno, M.
Fameli, C.
Etchenique, R.
Caged amino acids for visible-light photodelivery
topic_facet Caged compounds
Neurophysiology
Phototriggers
description We present a photocleavable protecting group based on ruthenium bipyridyl complexes and suitable for amino acid photodelivery. We discuss the photochemical properties of the caged glutamate, which is a major neurotransmitter in the CNS. The molar absorptivity for the caged glutamate at 450 nm is ε = 4200 M-1cm-1 and its quantum yield of photore-lease at 450 nm is ?̈PD = 0.035, which is about 17 times higher than that of the most active organic caged compound at this wavelength. Similar figures are obtained for other ?́-amino acids. © Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
format JOUR
author Salierno, M.
Fameli, C.
Etchenique, R.
author_facet Salierno, M.
Fameli, C.
Etchenique, R.
author_sort Salierno, M.
title Caged amino acids for visible-light photodelivery
title_short Caged amino acids for visible-light photodelivery
title_full Caged amino acids for visible-light photodelivery
title_fullStr Caged amino acids for visible-light photodelivery
title_full_unstemmed Caged amino acids for visible-light photodelivery
title_sort caged amino acids for visible-light photodelivery
url http://hdl.handle.net/20.500.12110/paper_14341948_v_n7_p1125_Salierno
work_keys_str_mv AT saliernom cagedaminoacidsforvisiblelightphotodelivery
AT famelic cagedaminoacidsforvisiblelightphotodelivery
AT etcheniquer cagedaminoacidsforvisiblelightphotodelivery
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