Synaptic control of local translation: The plot thickens with new characters
The production of proteins from mRNAs localized at the synapse ultimately controls the strength of synaptic transmission, thereby affecting behavior and cognitive functions. The regulated transcription, processing, and transport of mRNAs provide dynamic control of the dendritic transcriptome, which...
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todo:paper_1420682X_v71_n12_p2219_Thomas2023-10-03T16:13:29Z Synaptic control of local translation: The plot thickens with new characters Thomas, M.G. Pascual, M.L. Maschi, D. Luchelli, L. Boccaccio, G.L. Abnormal protein aggregation ARC/Arg3.1 EJC mTOR NMDAR Stress granules brain derived neurotrophic factor cytoplasmic polyadenylation element binding protein fused in sarcoma protein messenger RNA microRNA Piwi interacting RNA RNA binding protein small interfering RNA TAR DNA binding protein transcriptome untranslated RNA behavior cell function cognition dendritic spine gene silencing human molecular mechanics nerve cell plasticity nerve degeneration oligomerization protein aggregation regulatory mechanism repressor gene review RNA transport synaptic potential synaptic transmission transcription regulation Animals Gene Expression Regulation Humans Protein Biosynthesis Protein Transport Synapses Synaptic Transmission Transcriptome The production of proteins from mRNAs localized at the synapse ultimately controls the strength of synaptic transmission, thereby affecting behavior and cognitive functions. The regulated transcription, processing, and transport of mRNAs provide dynamic control of the dendritic transcriptome, which includes thousands of messengers encoding multiple cellular functions. Translation is locally modulated by synaptic activity through a complex network of RNA-binding proteins (RBPs) and various types of non-coding RNAs (ncRNAs) including BC-RNAs, microRNAs, piwi-interacting RNAs, and small interference RNAs. The RBPs FMRP and CPEB play a well-established role in synaptic translation, and additional regulatory factors are emerging. The mRNA repressors Smaug, Nanos, and Pumilio define a novel pathway for local translational control that affects dendritic branching and spines in both flies and mammals. Recent findings support a role for processing bodies and related synaptic mRNA-silencing foci (SyAS-foci) in the modulation of synaptic plasticity and memory formation. The SyAS-foci respond to different stimuli with changes in their integrity thus enabling regulated mRNA release followed by translation. CPEB, Pumilio, TDP-43, and FUS/TLS form multimers through low-complexity regions related to prion domains or polyQ expansions. The oligomerization of these repressor RBPs is mechanistically linked to the aggregation of abnormal proteins commonly associated with neurodegeneration. Here, we summarize the current knowledge on how specificity in mRNA translation is achieved through the concerted action of multiple pathways that involve regulatory ncRNAs and RBPs, the modification of translation factors, and mRNA-silencing foci dynamics. © 2013 Springer Basel. Fil:Thomas, M.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Maschi, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Luchelli, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Boccaccio, G.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_1420682X_v71_n12_p2219_Thomas |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Abnormal protein aggregation ARC/Arg3.1 EJC mTOR NMDAR Stress granules brain derived neurotrophic factor cytoplasmic polyadenylation element binding protein fused in sarcoma protein messenger RNA microRNA Piwi interacting RNA RNA binding protein small interfering RNA TAR DNA binding protein transcriptome untranslated RNA behavior cell function cognition dendritic spine gene silencing human molecular mechanics nerve cell plasticity nerve degeneration oligomerization protein aggregation regulatory mechanism repressor gene review RNA transport synaptic potential synaptic transmission transcription regulation Animals Gene Expression Regulation Humans Protein Biosynthesis Protein Transport Synapses Synaptic Transmission Transcriptome |
| spellingShingle |
Abnormal protein aggregation ARC/Arg3.1 EJC mTOR NMDAR Stress granules brain derived neurotrophic factor cytoplasmic polyadenylation element binding protein fused in sarcoma protein messenger RNA microRNA Piwi interacting RNA RNA binding protein small interfering RNA TAR DNA binding protein transcriptome untranslated RNA behavior cell function cognition dendritic spine gene silencing human molecular mechanics nerve cell plasticity nerve degeneration oligomerization protein aggregation regulatory mechanism repressor gene review RNA transport synaptic potential synaptic transmission transcription regulation Animals Gene Expression Regulation Humans Protein Biosynthesis Protein Transport Synapses Synaptic Transmission Transcriptome Thomas, M.G. Pascual, M.L. Maschi, D. Luchelli, L. Boccaccio, G.L. Synaptic control of local translation: The plot thickens with new characters |
| topic_facet |
Abnormal protein aggregation ARC/Arg3.1 EJC mTOR NMDAR Stress granules brain derived neurotrophic factor cytoplasmic polyadenylation element binding protein fused in sarcoma protein messenger RNA microRNA Piwi interacting RNA RNA binding protein small interfering RNA TAR DNA binding protein transcriptome untranslated RNA behavior cell function cognition dendritic spine gene silencing human molecular mechanics nerve cell plasticity nerve degeneration oligomerization protein aggregation regulatory mechanism repressor gene review RNA transport synaptic potential synaptic transmission transcription regulation Animals Gene Expression Regulation Humans Protein Biosynthesis Protein Transport Synapses Synaptic Transmission Transcriptome |
| description |
The production of proteins from mRNAs localized at the synapse ultimately controls the strength of synaptic transmission, thereby affecting behavior and cognitive functions. The regulated transcription, processing, and transport of mRNAs provide dynamic control of the dendritic transcriptome, which includes thousands of messengers encoding multiple cellular functions. Translation is locally modulated by synaptic activity through a complex network of RNA-binding proteins (RBPs) and various types of non-coding RNAs (ncRNAs) including BC-RNAs, microRNAs, piwi-interacting RNAs, and small interference RNAs. The RBPs FMRP and CPEB play a well-established role in synaptic translation, and additional regulatory factors are emerging. The mRNA repressors Smaug, Nanos, and Pumilio define a novel pathway for local translational control that affects dendritic branching and spines in both flies and mammals. Recent findings support a role for processing bodies and related synaptic mRNA-silencing foci (SyAS-foci) in the modulation of synaptic plasticity and memory formation. The SyAS-foci respond to different stimuli with changes in their integrity thus enabling regulated mRNA release followed by translation. CPEB, Pumilio, TDP-43, and FUS/TLS form multimers through low-complexity regions related to prion domains or polyQ expansions. The oligomerization of these repressor RBPs is mechanistically linked to the aggregation of abnormal proteins commonly associated with neurodegeneration. Here, we summarize the current knowledge on how specificity in mRNA translation is achieved through the concerted action of multiple pathways that involve regulatory ncRNAs and RBPs, the modification of translation factors, and mRNA-silencing foci dynamics. © 2013 Springer Basel. |
| format |
JOUR |
| author |
Thomas, M.G. Pascual, M.L. Maschi, D. Luchelli, L. Boccaccio, G.L. |
| author_facet |
Thomas, M.G. Pascual, M.L. Maschi, D. Luchelli, L. Boccaccio, G.L. |
| author_sort |
Thomas, M.G. |
| title |
Synaptic control of local translation: The plot thickens with new characters |
| title_short |
Synaptic control of local translation: The plot thickens with new characters |
| title_full |
Synaptic control of local translation: The plot thickens with new characters |
| title_fullStr |
Synaptic control of local translation: The plot thickens with new characters |
| title_full_unstemmed |
Synaptic control of local translation: The plot thickens with new characters |
| title_sort |
synaptic control of local translation: the plot thickens with new characters |
| url |
http://hdl.handle.net/20.500.12110/paper_1420682X_v71_n12_p2219_Thomas |
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