Tracking protein electrodenaturation fronts in the electrochemical treatment of tumors

Electrochemical reactions in the electrochemical treatment of tumors (EChT) induce extreme pH changes and, consequently, protein electrodenaturation fronts intimately related to tumor destruction. Here we introduce a new in vitro EChT collagen-macronutrient gel (CMG) model to study protein electrode...

Descripción completa

Detalles Bibliográficos
Autores principales: Olaiz, N., Suárez, C., Risk, M., Molina, F., Marshall, G.
Formato: JOUR
Materias:
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_13882481_v12_n1_p94_Olaiz
Aporte de:
id todo:paper_13882481_v12_n1_p94_Olaiz
record_format dspace
spelling todo:paper_13882481_v12_n1_p94_Olaiz2023-10-03T16:12:36Z Tracking protein electrodenaturation fronts in the electrochemical treatment of tumors Olaiz, N. Suárez, C. Risk, M. Molina, F. Marshall, G. Electrochemical treatment Electrodenaturation In vitro models Tumors Accurate prediction Diffusion-controlled regime Electrochemical reactions Electrochemical treatments Electrodenaturation Front tracking Healthy tissues In-silico In-vitro In-vivo pH change Tissue destruction Grinding machines Oncology Proteins Tumors Electrochemical reactions in the electrochemical treatment of tumors (EChT) induce extreme pH changes and, consequently, protein electrodenaturation fronts intimately related to tumor destruction. Here we introduce a new in vitro EChT collagen-macronutrient gel (CMG) model to study protein electrodenaturation fronts as a mean of assessing EChT effectiveness. Our CMG model shows that from an initial uniform condition two electrodenaturation fronts evolve expanding towards each other until collision. Moreover, electrodenaturation front tracking reveals that the front grows under a diffusion-controlled regime. Based on this evidence it is possible, in principle, to predict the time needed for tumor destruction without compromising healthy tissue. These results are consistent with those previously obtained with in vivo and in vitro EChT modeling. In contrast to previous simpler in vitro models, our CMG model represents a better structural and chemical approximation to a real tissue thus providing a better tool for validation of new in silico EChT models aimed at a more accurate prediction of tissue destruction level. © 2009 Elsevier B.V. All rights reserved. Fil:Suárez, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Molina, F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_13882481_v12_n1_p94_Olaiz
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Electrochemical treatment
Electrodenaturation
In vitro models
Tumors
Accurate prediction
Diffusion-controlled regime
Electrochemical reactions
Electrochemical treatments
Electrodenaturation
Front tracking
Healthy tissues
In-silico
In-vitro
In-vivo
pH change
Tissue destruction
Grinding machines
Oncology
Proteins
Tumors
spellingShingle Electrochemical treatment
Electrodenaturation
In vitro models
Tumors
Accurate prediction
Diffusion-controlled regime
Electrochemical reactions
Electrochemical treatments
Electrodenaturation
Front tracking
Healthy tissues
In-silico
In-vitro
In-vivo
pH change
Tissue destruction
Grinding machines
Oncology
Proteins
Tumors
Olaiz, N.
Suárez, C.
Risk, M.
Molina, F.
Marshall, G.
Tracking protein electrodenaturation fronts in the electrochemical treatment of tumors
topic_facet Electrochemical treatment
Electrodenaturation
In vitro models
Tumors
Accurate prediction
Diffusion-controlled regime
Electrochemical reactions
Electrochemical treatments
Electrodenaturation
Front tracking
Healthy tissues
In-silico
In-vitro
In-vivo
pH change
Tissue destruction
Grinding machines
Oncology
Proteins
Tumors
description Electrochemical reactions in the electrochemical treatment of tumors (EChT) induce extreme pH changes and, consequently, protein electrodenaturation fronts intimately related to tumor destruction. Here we introduce a new in vitro EChT collagen-macronutrient gel (CMG) model to study protein electrodenaturation fronts as a mean of assessing EChT effectiveness. Our CMG model shows that from an initial uniform condition two electrodenaturation fronts evolve expanding towards each other until collision. Moreover, electrodenaturation front tracking reveals that the front grows under a diffusion-controlled regime. Based on this evidence it is possible, in principle, to predict the time needed for tumor destruction without compromising healthy tissue. These results are consistent with those previously obtained with in vivo and in vitro EChT modeling. In contrast to previous simpler in vitro models, our CMG model represents a better structural and chemical approximation to a real tissue thus providing a better tool for validation of new in silico EChT models aimed at a more accurate prediction of tissue destruction level. © 2009 Elsevier B.V. All rights reserved.
format JOUR
author Olaiz, N.
Suárez, C.
Risk, M.
Molina, F.
Marshall, G.
author_facet Olaiz, N.
Suárez, C.
Risk, M.
Molina, F.
Marshall, G.
author_sort Olaiz, N.
title Tracking protein electrodenaturation fronts in the electrochemical treatment of tumors
title_short Tracking protein electrodenaturation fronts in the electrochemical treatment of tumors
title_full Tracking protein electrodenaturation fronts in the electrochemical treatment of tumors
title_fullStr Tracking protein electrodenaturation fronts in the electrochemical treatment of tumors
title_full_unstemmed Tracking protein electrodenaturation fronts in the electrochemical treatment of tumors
title_sort tracking protein electrodenaturation fronts in the electrochemical treatment of tumors
url http://hdl.handle.net/20.500.12110/paper_13882481_v12_n1_p94_Olaiz
work_keys_str_mv AT olaizn trackingproteinelectrodenaturationfrontsintheelectrochemicaltreatmentoftumors
AT suarezc trackingproteinelectrodenaturationfrontsintheelectrochemicaltreatmentoftumors
AT riskm trackingproteinelectrodenaturationfrontsintheelectrochemicaltreatmentoftumors
AT molinaf trackingproteinelectrodenaturationfrontsintheelectrochemicaltreatmentoftumors
AT marshallg trackingproteinelectrodenaturationfrontsintheelectrochemicaltreatmentoftumors
_version_ 1807324020591296512