ROS enhancement by silicon nanoparticles in X-ray irradiated aqueous suspensions and in glioma C6 cells
The capability of silicon nanoparticles to increase the yield of reactive species upon 4 MeV X-ray irradiation of aqueous suspensions and C6 glioma cell cultures was investigated. ROS generation was detected and quantified using several specific probes. The particles were characterized by FTIR, XPS,...
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todo:paper_13880764_v14_n3_p_Gara2023-10-03T16:12:34Z ROS enhancement by silicon nanoparticles in X-ray irradiated aqueous suspensions and in glioma C6 cells Gara, P.M.D. Garabano, N.I. Portoles, M.J.L. Moreno, M.S. Dodat, D. Casas, O.R. Gonzalez, M.C. Kotler, M.L. Glioma C6 cells Radiotherapy ROS Silicon nanoparticles Singlet molecular Oxygen X-rays Aqueous suspensions C6 cells Cytotoxic Experimental errors FTIR High energy radiation Irradiation dose Irradiation experiments Particle surface Radiosensitizers Reactive species ROS Silicon nanoparticles Singlet molecular oxygen Therapy strategies X ray irradiation Adsorption Cell culture Experiments Fourier transform infrared spectroscopy Irradiation Luminescence Nanoparticles Radiation Radiotherapy Silicon oxides Tumors X rays Suspensions (fluids) hydrogen peroxide nanoparticle radiosensitizing agent reactive oxygen metabolite scavenger silicon silicon dioxide silicon nanoparticle singlet oxygen unclassified drug adsorption spectroscopy animal cell article cancer radiotherapy cell suspension chemical structure controlled study cytotoxicity glioma cell infrared spectroscopy ionizing radiation light scattering luminescence nonhuman particle size priority journal radiation dose radiation response rat spectroscopy surface property transmission electron microscopy tumor cell culture X ray X ray photoelectron spectroscopy The capability of silicon nanoparticles to increase the yield of reactive species upon 4 MeV X-ray irradiation of aqueous suspensions and C6 glioma cell cultures was investigated. ROS generation was detected and quantified using several specific probes. The particles were characterized by FTIR, XPS, TEM, DLS, luminescence, and adsorption spectroscopy before and after irradiation to evaluate the effect of high energy radiation on their structure. The total concentration of O 2 ·-/HO 2 ·, HO ·, and H 2O 2 generated upon 4-MeV X-ray irradiation of 6.4 μM silicon nanoparticle aqueous suspensions were on the order of 10 μM per Gy, ten times higher than that obtained in similar experiments but in the absence of particles. Cytotoxic 1O 2 was generated only in irradiation experiments containing the particles. The particle surface became oxidized to SiO 2 and the luminescence yield reduced with the irradiation dose. Changes in the surface morphology did not affect, within the experimental error, the yields ofROSgenerated per Gy. X-ray irradiation of glioma C6 cell cultures with incorporated silicon nanoparticles showed a marked production of ROS proportional to the radiation dose received. In the absence of nanoparticles, the cells showed no irradiation- enhanced ROS generation. The obtained results indicate that silicon nanoparticles of <5 nm size have the potential to be used as radiosensitizers for improving the outcomes of cancer radiotherapy. Their capability of producing 1O 2 upon X-ray irradiation opens novel approaches in the design of therapy strategies. © Springer Science+Business Media B.V. 2012. Fil:Gonzalez, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kotler, M.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_13880764_v14_n3_p_Gara |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
Glioma C6 cells Radiotherapy ROS Silicon nanoparticles Singlet molecular Oxygen X-rays Aqueous suspensions C6 cells Cytotoxic Experimental errors FTIR High energy radiation Irradiation dose Irradiation experiments Particle surface Radiosensitizers Reactive species ROS Silicon nanoparticles Singlet molecular oxygen Therapy strategies X ray irradiation Adsorption Cell culture Experiments Fourier transform infrared spectroscopy Irradiation Luminescence Nanoparticles Radiation Radiotherapy Silicon oxides Tumors X rays Suspensions (fluids) hydrogen peroxide nanoparticle radiosensitizing agent reactive oxygen metabolite scavenger silicon silicon dioxide silicon nanoparticle singlet oxygen unclassified drug adsorption spectroscopy animal cell article cancer radiotherapy cell suspension chemical structure controlled study cytotoxicity glioma cell infrared spectroscopy ionizing radiation light scattering luminescence nonhuman particle size priority journal radiation dose radiation response rat spectroscopy surface property transmission electron microscopy tumor cell culture X ray X ray photoelectron spectroscopy |
spellingShingle |
Glioma C6 cells Radiotherapy ROS Silicon nanoparticles Singlet molecular Oxygen X-rays Aqueous suspensions C6 cells Cytotoxic Experimental errors FTIR High energy radiation Irradiation dose Irradiation experiments Particle surface Radiosensitizers Reactive species ROS Silicon nanoparticles Singlet molecular oxygen Therapy strategies X ray irradiation Adsorption Cell culture Experiments Fourier transform infrared spectroscopy Irradiation Luminescence Nanoparticles Radiation Radiotherapy Silicon oxides Tumors X rays Suspensions (fluids) hydrogen peroxide nanoparticle radiosensitizing agent reactive oxygen metabolite scavenger silicon silicon dioxide silicon nanoparticle singlet oxygen unclassified drug adsorption spectroscopy animal cell article cancer radiotherapy cell suspension chemical structure controlled study cytotoxicity glioma cell infrared spectroscopy ionizing radiation light scattering luminescence nonhuman particle size priority journal radiation dose radiation response rat spectroscopy surface property transmission electron microscopy tumor cell culture X ray X ray photoelectron spectroscopy Gara, P.M.D. Garabano, N.I. Portoles, M.J.L. Moreno, M.S. Dodat, D. Casas, O.R. Gonzalez, M.C. Kotler, M.L. ROS enhancement by silicon nanoparticles in X-ray irradiated aqueous suspensions and in glioma C6 cells |
topic_facet |
Glioma C6 cells Radiotherapy ROS Silicon nanoparticles Singlet molecular Oxygen X-rays Aqueous suspensions C6 cells Cytotoxic Experimental errors FTIR High energy radiation Irradiation dose Irradiation experiments Particle surface Radiosensitizers Reactive species ROS Silicon nanoparticles Singlet molecular oxygen Therapy strategies X ray irradiation Adsorption Cell culture Experiments Fourier transform infrared spectroscopy Irradiation Luminescence Nanoparticles Radiation Radiotherapy Silicon oxides Tumors X rays Suspensions (fluids) hydrogen peroxide nanoparticle radiosensitizing agent reactive oxygen metabolite scavenger silicon silicon dioxide silicon nanoparticle singlet oxygen unclassified drug adsorption spectroscopy animal cell article cancer radiotherapy cell suspension chemical structure controlled study cytotoxicity glioma cell infrared spectroscopy ionizing radiation light scattering luminescence nonhuman particle size priority journal radiation dose radiation response rat spectroscopy surface property transmission electron microscopy tumor cell culture X ray X ray photoelectron spectroscopy |
description |
The capability of silicon nanoparticles to increase the yield of reactive species upon 4 MeV X-ray irradiation of aqueous suspensions and C6 glioma cell cultures was investigated. ROS generation was detected and quantified using several specific probes. The particles were characterized by FTIR, XPS, TEM, DLS, luminescence, and adsorption spectroscopy before and after irradiation to evaluate the effect of high energy radiation on their structure. The total concentration of O 2 ·-/HO 2 ·, HO ·, and H 2O 2 generated upon 4-MeV X-ray irradiation of 6.4 μM silicon nanoparticle aqueous suspensions were on the order of 10 μM per Gy, ten times higher than that obtained in similar experiments but in the absence of particles. Cytotoxic 1O 2 was generated only in irradiation experiments containing the particles. The particle surface became oxidized to SiO 2 and the luminescence yield reduced with the irradiation dose. Changes in the surface morphology did not affect, within the experimental error, the yields ofROSgenerated per Gy. X-ray irradiation of glioma C6 cell cultures with incorporated silicon nanoparticles showed a marked production of ROS proportional to the radiation dose received. In the absence of nanoparticles, the cells showed no irradiation- enhanced ROS generation. The obtained results indicate that silicon nanoparticles of <5 nm size have the potential to be used as radiosensitizers for improving the outcomes of cancer radiotherapy. Their capability of producing 1O 2 upon X-ray irradiation opens novel approaches in the design of therapy strategies. © Springer Science+Business Media B.V. 2012. |
format |
JOUR |
author |
Gara, P.M.D. Garabano, N.I. Portoles, M.J.L. Moreno, M.S. Dodat, D. Casas, O.R. Gonzalez, M.C. Kotler, M.L. |
author_facet |
Gara, P.M.D. Garabano, N.I. Portoles, M.J.L. Moreno, M.S. Dodat, D. Casas, O.R. Gonzalez, M.C. Kotler, M.L. |
author_sort |
Gara, P.M.D. |
title |
ROS enhancement by silicon nanoparticles in X-ray irradiated aqueous suspensions and in glioma C6 cells |
title_short |
ROS enhancement by silicon nanoparticles in X-ray irradiated aqueous suspensions and in glioma C6 cells |
title_full |
ROS enhancement by silicon nanoparticles in X-ray irradiated aqueous suspensions and in glioma C6 cells |
title_fullStr |
ROS enhancement by silicon nanoparticles in X-ray irradiated aqueous suspensions and in glioma C6 cells |
title_full_unstemmed |
ROS enhancement by silicon nanoparticles in X-ray irradiated aqueous suspensions and in glioma C6 cells |
title_sort |
ros enhancement by silicon nanoparticles in x-ray irradiated aqueous suspensions and in glioma c6 cells |
url |
http://hdl.handle.net/20.500.12110/paper_13880764_v14_n3_p_Gara |
work_keys_str_mv |
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1782030438042173440 |