Biomarkers of genotoxicity and genomic instability in a non-human primate, Cebus libidinosus (Cebidae, Platyrrhini), exposed to nitroimidazole derivatives
The genotoxicity of two nitroimidazole derivatives, ornidazole (ONZ) and metronidazole (MTZ) in the peripheral blood lymphocytes of Cebus libidinosus (CLI) (Primates, Cebidae) was assessed. Endpoints measured included sister chromatid exchange (SCE) frequency, cell proliferation kinetics (CPK), repl...
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todo:paper_13835718_v721_n1_p108_Mudry2023-10-03T16:11:56Z Biomarkers of genotoxicity and genomic instability in a non-human primate, Cebus libidinosus (Cebidae, Platyrrhini), exposed to nitroimidazole derivatives Mudry, M.D. Martinez, R.A. Nieves, M. Carballo, M.A. Cebus libidinosus Genotoxicity Heterochromatin Nitroimidazoles Sister chromatid exchange metronidazole ornidazole animal cell animal experiment article Cebus libidinosus cell damage cell division cell proliferation chromosome 11q chromosome 12q chromosome 13q chromosome 17 chromosome 17q chromosome 1p chromosome 1q chromosome 2q chromosome 4q chromosome 6q chromosome 8q chromosome banding pattern chromosome size controlled study drug exposure genetic marker genomic instability genotoxicity heterochromatin lymphocyte mitosis nonhuman primate priority journal sister chromatid exchange Animals Biological Markers Cebus DNA Damage Genomic Instability Metronidazole Mitotic Index Mutagens Ornidazole Sister Chromatid Exchange Cebidae Cebus libidinosus Platyrrhini Primates The genotoxicity of two nitroimidazole derivatives, ornidazole (ONZ) and metronidazole (MTZ) in the peripheral blood lymphocytes of Cebus libidinosus (CLI) (Primates, Cebidae) was assessed. Endpoints measured included sister chromatid exchange (SCE) frequency, cell proliferation kinetics (CPK), replication index (RI), mitotic index (MI), and damage incidence in or near CLI heterochromatin regions. MI and SCE values following ONZ or MTZ treatments were significantly different (p<0.001) from control. SCE frequency per chromosome was not proportional to chromosome length. The chromosomes most affected for SCE were 1, 2, 4, 6, 11-13, 17, and 18, many of which possess interstitial or terminal heterochromatin. In the CLI genome, chromosomes 11 and 17 showed higher susceptibility to damage RI was the only biomarker that did not show statistically significant differences between control and treated cultures. C. libidinosus bands 11q1.4 and 11q1.5 may be hot-spots in the context of nitroimidazole exposure. © 2011 Elsevier B.V. Fil:Mudry, M.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Martinez, R.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Nieves, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_13835718_v721_n1_p108_Mudry |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
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R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Cebus libidinosus Genotoxicity Heterochromatin Nitroimidazoles Sister chromatid exchange metronidazole ornidazole animal cell animal experiment article Cebus libidinosus cell damage cell division cell proliferation chromosome 11q chromosome 12q chromosome 13q chromosome 17 chromosome 17q chromosome 1p chromosome 1q chromosome 2q chromosome 4q chromosome 6q chromosome 8q chromosome banding pattern chromosome size controlled study drug exposure genetic marker genomic instability genotoxicity heterochromatin lymphocyte mitosis nonhuman primate priority journal sister chromatid exchange Animals Biological Markers Cebus DNA Damage Genomic Instability Metronidazole Mitotic Index Mutagens Ornidazole Sister Chromatid Exchange Cebidae Cebus libidinosus Platyrrhini Primates |
| spellingShingle |
Cebus libidinosus Genotoxicity Heterochromatin Nitroimidazoles Sister chromatid exchange metronidazole ornidazole animal cell animal experiment article Cebus libidinosus cell damage cell division cell proliferation chromosome 11q chromosome 12q chromosome 13q chromosome 17 chromosome 17q chromosome 1p chromosome 1q chromosome 2q chromosome 4q chromosome 6q chromosome 8q chromosome banding pattern chromosome size controlled study drug exposure genetic marker genomic instability genotoxicity heterochromatin lymphocyte mitosis nonhuman primate priority journal sister chromatid exchange Animals Biological Markers Cebus DNA Damage Genomic Instability Metronidazole Mitotic Index Mutagens Ornidazole Sister Chromatid Exchange Cebidae Cebus libidinosus Platyrrhini Primates Mudry, M.D. Martinez, R.A. Nieves, M. Carballo, M.A. Biomarkers of genotoxicity and genomic instability in a non-human primate, Cebus libidinosus (Cebidae, Platyrrhini), exposed to nitroimidazole derivatives |
| topic_facet |
Cebus libidinosus Genotoxicity Heterochromatin Nitroimidazoles Sister chromatid exchange metronidazole ornidazole animal cell animal experiment article Cebus libidinosus cell damage cell division cell proliferation chromosome 11q chromosome 12q chromosome 13q chromosome 17 chromosome 17q chromosome 1p chromosome 1q chromosome 2q chromosome 4q chromosome 6q chromosome 8q chromosome banding pattern chromosome size controlled study drug exposure genetic marker genomic instability genotoxicity heterochromatin lymphocyte mitosis nonhuman primate priority journal sister chromatid exchange Animals Biological Markers Cebus DNA Damage Genomic Instability Metronidazole Mitotic Index Mutagens Ornidazole Sister Chromatid Exchange Cebidae Cebus libidinosus Platyrrhini Primates |
| description |
The genotoxicity of two nitroimidazole derivatives, ornidazole (ONZ) and metronidazole (MTZ) in the peripheral blood lymphocytes of Cebus libidinosus (CLI) (Primates, Cebidae) was assessed. Endpoints measured included sister chromatid exchange (SCE) frequency, cell proliferation kinetics (CPK), replication index (RI), mitotic index (MI), and damage incidence in or near CLI heterochromatin regions. MI and SCE values following ONZ or MTZ treatments were significantly different (p<0.001) from control. SCE frequency per chromosome was not proportional to chromosome length. The chromosomes most affected for SCE were 1, 2, 4, 6, 11-13, 17, and 18, many of which possess interstitial or terminal heterochromatin. In the CLI genome, chromosomes 11 and 17 showed higher susceptibility to damage RI was the only biomarker that did not show statistically significant differences between control and treated cultures. C. libidinosus bands 11q1.4 and 11q1.5 may be hot-spots in the context of nitroimidazole exposure. © 2011 Elsevier B.V. |
| format |
JOUR |
| author |
Mudry, M.D. Martinez, R.A. Nieves, M. Carballo, M.A. |
| author_facet |
Mudry, M.D. Martinez, R.A. Nieves, M. Carballo, M.A. |
| author_sort |
Mudry, M.D. |
| title |
Biomarkers of genotoxicity and genomic instability in a non-human primate, Cebus libidinosus (Cebidae, Platyrrhini), exposed to nitroimidazole derivatives |
| title_short |
Biomarkers of genotoxicity and genomic instability in a non-human primate, Cebus libidinosus (Cebidae, Platyrrhini), exposed to nitroimidazole derivatives |
| title_full |
Biomarkers of genotoxicity and genomic instability in a non-human primate, Cebus libidinosus (Cebidae, Platyrrhini), exposed to nitroimidazole derivatives |
| title_fullStr |
Biomarkers of genotoxicity and genomic instability in a non-human primate, Cebus libidinosus (Cebidae, Platyrrhini), exposed to nitroimidazole derivatives |
| title_full_unstemmed |
Biomarkers of genotoxicity and genomic instability in a non-human primate, Cebus libidinosus (Cebidae, Platyrrhini), exposed to nitroimidazole derivatives |
| title_sort |
biomarkers of genotoxicity and genomic instability in a non-human primate, cebus libidinosus (cebidae, platyrrhini), exposed to nitroimidazole derivatives |
| url |
http://hdl.handle.net/20.500.12110/paper_13835718_v721_n1_p108_Mudry |
| work_keys_str_mv |
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