Specific molecular targets to control tropical diseases
Chagas' disease or American trypanosomiasis is considered by the Word Health Organization to be one of the important tropical parasitic diseases worldwide together with malaria and schistosomiasis. The etiologic agent of this illness is the kinetoplastid protozoon Trypanosoma cruzi. The present...
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todo:paper_13816128_v7_n12_p1105_Rodriguez2023-10-03T16:11:52Z Specific molecular targets to control tropical diseases Rodriguez, J.B. 4 phenoxyphenoxyethyl allyl ether 4 phenoxyphenoxyethyl tetrahydro 2h pyran 2 yl ether 4 phenoxyphenoxyethyl thiocyanate antiinfective agent aryloxyethyl thiocyanate benznidazole benzoic acid derivative crystal violet dihydrofolate reductase inhibitor enzyme inhibitor ether derivative fenoxycarb glyceraldehyde 3 phosphate dehydrogenase inhibitor m chloroperbenzoic acid methotrexate n acetyl 2,3 didehydro 2 deoxyneuraminic acid n acetylneuraminic acid derivative nifurtimox sialidase thiocyanic acid derivative unclassified drug animal experiment animal model anorexia article Chagas disease controlled study drug design drug structure drug targeting host human kinetoplast malaria mammal molecular biology mouse nonhuman peripheral neuropathy priority journal protozoon schistosomiasis skin allergy tropical disease Trypanosoma cruzi vomiting world health organization Animals Antiprotozoal Agents Chagas Disease Drug Design Humans Trypanosoma cruzi Chagas' disease or American trypanosomiasis is considered by the Word Health Organization to be one of the important tropical parasitic diseases worldwide together with malaria and schistosomiasis. The etiologic agent of this illness is the kinetoplastid protozoon Trypanosoma cruzi. The present chemotherapy for the treatment of Chagas' disease remains unsolved. The drugs currently in use are old, ineffective and toxic. Bearing in mind the metabolic differences between the parasite and the mammalian host, some attractive interesting molecular targets for drug design are presented. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_13816128_v7_n12_p1105_Rodriguez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
4 phenoxyphenoxyethyl allyl ether 4 phenoxyphenoxyethyl tetrahydro 2h pyran 2 yl ether 4 phenoxyphenoxyethyl thiocyanate antiinfective agent aryloxyethyl thiocyanate benznidazole benzoic acid derivative crystal violet dihydrofolate reductase inhibitor enzyme inhibitor ether derivative fenoxycarb glyceraldehyde 3 phosphate dehydrogenase inhibitor m chloroperbenzoic acid methotrexate n acetyl 2,3 didehydro 2 deoxyneuraminic acid n acetylneuraminic acid derivative nifurtimox sialidase thiocyanic acid derivative unclassified drug animal experiment animal model anorexia article Chagas disease controlled study drug design drug structure drug targeting host human kinetoplast malaria mammal molecular biology mouse nonhuman peripheral neuropathy priority journal protozoon schistosomiasis skin allergy tropical disease Trypanosoma cruzi vomiting world health organization Animals Antiprotozoal Agents Chagas Disease Drug Design Humans Trypanosoma cruzi |
| spellingShingle |
4 phenoxyphenoxyethyl allyl ether 4 phenoxyphenoxyethyl tetrahydro 2h pyran 2 yl ether 4 phenoxyphenoxyethyl thiocyanate antiinfective agent aryloxyethyl thiocyanate benznidazole benzoic acid derivative crystal violet dihydrofolate reductase inhibitor enzyme inhibitor ether derivative fenoxycarb glyceraldehyde 3 phosphate dehydrogenase inhibitor m chloroperbenzoic acid methotrexate n acetyl 2,3 didehydro 2 deoxyneuraminic acid n acetylneuraminic acid derivative nifurtimox sialidase thiocyanic acid derivative unclassified drug animal experiment animal model anorexia article Chagas disease controlled study drug design drug structure drug targeting host human kinetoplast malaria mammal molecular biology mouse nonhuman peripheral neuropathy priority journal protozoon schistosomiasis skin allergy tropical disease Trypanosoma cruzi vomiting world health organization Animals Antiprotozoal Agents Chagas Disease Drug Design Humans Trypanosoma cruzi Rodriguez, J.B. Specific molecular targets to control tropical diseases |
| topic_facet |
4 phenoxyphenoxyethyl allyl ether 4 phenoxyphenoxyethyl tetrahydro 2h pyran 2 yl ether 4 phenoxyphenoxyethyl thiocyanate antiinfective agent aryloxyethyl thiocyanate benznidazole benzoic acid derivative crystal violet dihydrofolate reductase inhibitor enzyme inhibitor ether derivative fenoxycarb glyceraldehyde 3 phosphate dehydrogenase inhibitor m chloroperbenzoic acid methotrexate n acetyl 2,3 didehydro 2 deoxyneuraminic acid n acetylneuraminic acid derivative nifurtimox sialidase thiocyanic acid derivative unclassified drug animal experiment animal model anorexia article Chagas disease controlled study drug design drug structure drug targeting host human kinetoplast malaria mammal molecular biology mouse nonhuman peripheral neuropathy priority journal protozoon schistosomiasis skin allergy tropical disease Trypanosoma cruzi vomiting world health organization Animals Antiprotozoal Agents Chagas Disease Drug Design Humans Trypanosoma cruzi |
| description |
Chagas' disease or American trypanosomiasis is considered by the Word Health Organization to be one of the important tropical parasitic diseases worldwide together with malaria and schistosomiasis. The etiologic agent of this illness is the kinetoplastid protozoon Trypanosoma cruzi. The present chemotherapy for the treatment of Chagas' disease remains unsolved. The drugs currently in use are old, ineffective and toxic. Bearing in mind the metabolic differences between the parasite and the mammalian host, some attractive interesting molecular targets for drug design are presented. |
| format |
JOUR |
| author |
Rodriguez, J.B. |
| author_facet |
Rodriguez, J.B. |
| author_sort |
Rodriguez, J.B. |
| title |
Specific molecular targets to control tropical diseases |
| title_short |
Specific molecular targets to control tropical diseases |
| title_full |
Specific molecular targets to control tropical diseases |
| title_fullStr |
Specific molecular targets to control tropical diseases |
| title_full_unstemmed |
Specific molecular targets to control tropical diseases |
| title_sort |
specific molecular targets to control tropical diseases |
| url |
http://hdl.handle.net/20.500.12110/paper_13816128_v7_n12_p1105_Rodriguez |
| work_keys_str_mv |
AT rodriguezjb specificmoleculartargetstocontroltropicaldiseases |
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1807323309301301248 |