Microbial synthesis of 2,6-diaminopurine nucleosides

2,6-Diaminopurine nucleosides are used as pharmaceutical drugs or prodrugs against cancer and viral diseases. The synthesis of 2,6-diaminopurine riboside, -2′-deoxyriboside, -2′,3′-dideoxyriboside and -arabinofuranoside was efficiently carried out by transglycosylation using bacterial whole cells as...

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Autores principales:	Médici, R., Lewkowicz, E.S., Iribarren, A.M.
Formato:	JOUR
Materias:	2,6-Diaminopurine nucleoside Microbial transglycosylation Nucleoside analogues Whole cells Bacteria Biocatalysts Derivatives Diseases Drug products Synthesis (chemical) Nucleosides Nitrogen compounds 2 aminoadenosine 2' deoxyriboside 2',3' dideoxyriboside arabinofuranoside nucleoside derivative unclassified drug Achromobacter Aeromonas Arthrobacter article Bacillus bacterial cell biocatalyst Brevibacterium Cellulomonas Citrobacter Corynebacterium drug synthesis Enterobacter Erwinia Escherichia coli glycosylation Klebsiella Micrococcus nonhuman Proteus Pseudomonas Rhizobium Serratia Staphylococcus whole cell Xanthomonas Bacillus (bacterium) Bacteria (microorganisms) Proteus (enterobacteria)
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_13811177_v39_n1-4_p40_Medici
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_13811177_v39_n1-4_p40_Medici2023-10-03T16:11:44Z Microbial synthesis of 2,6-diaminopurine nucleosides Médici, R. Lewkowicz, E.S. Iribarren, A.M. 2,6-Diaminopurine nucleoside Microbial transglycosylation Nucleoside analogues Whole cells Bacteria Biocatalysts Derivatives Diseases Drug products Synthesis (chemical) Microbial transglycosylation Nucleoside analogues Nucleosides Whole cells Nitrogen compounds 2 aminoadenosine 2' deoxyriboside 2',3' dideoxyriboside arabinofuranoside nucleoside derivative unclassified drug Achromobacter Aeromonas Arthrobacter article Bacillus bacterial cell biocatalyst Brevibacterium Cellulomonas Citrobacter Corynebacterium drug synthesis Enterobacter Erwinia Escherichia coli glycosylation Klebsiella Micrococcus nonhuman Proteus Pseudomonas Rhizobium Serratia Staphylococcus whole cell Xanthomonas Achromobacter Aeromonas Arthrobacter Bacillus (bacterium) Bacteria (microorganisms) Brevibacterium Cellulomonas Citrobacter Corynebacterium Enterobacter Erwinia Escherichia coli Klebsiella Micrococcus Proteus (enterobacteria) Pseudomonas Rhizobium Serratia Staphylococcus Xanthomonas 2,6-Diaminopurine nucleosides are used as pharmaceutical drugs or prodrugs against cancer and viral diseases. The synthesis of 2,6-diaminopurine riboside, -2′-deoxyriboside, -2′,3′-dideoxyriboside and -arabinofuranoside was efficiently carried out by transglycosylation using bacterial whole cells as biocatalysts. The preparation of 2,6-diaminopurine-2′,3′-dideoxyriboside catalysed by whole cells is here reported for the first time. © 2006 Elsevier B.V. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_13811177_v39_n1-4_p40_Medici
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	2,6-Diaminopurine nucleoside Microbial transglycosylation Nucleoside analogues Whole cells Bacteria Biocatalysts Derivatives Diseases Drug products Synthesis (chemical) Microbial transglycosylation Nucleoside analogues Nucleosides Whole cells Nitrogen compounds 2 aminoadenosine 2' deoxyriboside 2',3' dideoxyriboside arabinofuranoside nucleoside derivative unclassified drug Achromobacter Aeromonas Arthrobacter article Bacillus bacterial cell biocatalyst Brevibacterium Cellulomonas Citrobacter Corynebacterium drug synthesis Enterobacter Erwinia Escherichia coli glycosylation Klebsiella Micrococcus nonhuman Proteus Pseudomonas Rhizobium Serratia Staphylococcus whole cell Xanthomonas Achromobacter Aeromonas Arthrobacter Bacillus (bacterium) Bacteria (microorganisms) Brevibacterium Cellulomonas Citrobacter Corynebacterium Enterobacter Erwinia Escherichia coli Klebsiella Micrococcus Proteus (enterobacteria) Pseudomonas Rhizobium Serratia Staphylococcus Xanthomonas
spellingShingle	2,6-Diaminopurine nucleoside Microbial transglycosylation Nucleoside analogues Whole cells Bacteria Biocatalysts Derivatives Diseases Drug products Synthesis (chemical) Microbial transglycosylation Nucleoside analogues Nucleosides Whole cells Nitrogen compounds 2 aminoadenosine 2' deoxyriboside 2',3' dideoxyriboside arabinofuranoside nucleoside derivative unclassified drug Achromobacter Aeromonas Arthrobacter article Bacillus bacterial cell biocatalyst Brevibacterium Cellulomonas Citrobacter Corynebacterium drug synthesis Enterobacter Erwinia Escherichia coli glycosylation Klebsiella Micrococcus nonhuman Proteus Pseudomonas Rhizobium Serratia Staphylococcus whole cell Xanthomonas Achromobacter Aeromonas Arthrobacter Bacillus (bacterium) Bacteria (microorganisms) Brevibacterium Cellulomonas Citrobacter Corynebacterium Enterobacter Erwinia Escherichia coli Klebsiella Micrococcus Proteus (enterobacteria) Pseudomonas Rhizobium Serratia Staphylococcus Xanthomonas Médici, R. Lewkowicz, E.S. Iribarren, A.M. Microbial synthesis of 2,6-diaminopurine nucleosides
topic_facet	2,6-Diaminopurine nucleoside Microbial transglycosylation Nucleoside analogues Whole cells Bacteria Biocatalysts Derivatives Diseases Drug products Synthesis (chemical) Microbial transglycosylation Nucleoside analogues Nucleosides Whole cells Nitrogen compounds 2 aminoadenosine 2' deoxyriboside 2',3' dideoxyriboside arabinofuranoside nucleoside derivative unclassified drug Achromobacter Aeromonas Arthrobacter article Bacillus bacterial cell biocatalyst Brevibacterium Cellulomonas Citrobacter Corynebacterium drug synthesis Enterobacter Erwinia Escherichia coli glycosylation Klebsiella Micrococcus nonhuman Proteus Pseudomonas Rhizobium Serratia Staphylococcus whole cell Xanthomonas Achromobacter Aeromonas Arthrobacter Bacillus (bacterium) Bacteria (microorganisms) Brevibacterium Cellulomonas Citrobacter Corynebacterium Enterobacter Erwinia Escherichia coli Klebsiella Micrococcus Proteus (enterobacteria) Pseudomonas Rhizobium Serratia Staphylococcus Xanthomonas
description	2,6-Diaminopurine nucleosides are used as pharmaceutical drugs or prodrugs against cancer and viral diseases. The synthesis of 2,6-diaminopurine riboside, -2′-deoxyriboside, -2′,3′-dideoxyriboside and -arabinofuranoside was efficiently carried out by transglycosylation using bacterial whole cells as biocatalysts. The preparation of 2,6-diaminopurine-2′,3′-dideoxyriboside catalysed by whole cells is here reported for the first time. © 2006 Elsevier B.V. All rights reserved.
format	JOUR
author	Médici, R. Lewkowicz, E.S. Iribarren, A.M.
author_facet	Médici, R. Lewkowicz, E.S. Iribarren, A.M.
author_sort	Médici, R.
title	Microbial synthesis of 2,6-diaminopurine nucleosides
title_short	Microbial synthesis of 2,6-diaminopurine nucleosides
title_full	Microbial synthesis of 2,6-diaminopurine nucleosides
title_fullStr	Microbial synthesis of 2,6-diaminopurine nucleosides
title_full_unstemmed	Microbial synthesis of 2,6-diaminopurine nucleosides
title_sort	microbial synthesis of 2,6-diaminopurine nucleosides
url	http://hdl.handle.net/20.500.12110/paper_13811177_v39_n1-4_p40_Medici
work_keys_str_mv	AT medicir microbialsynthesisof26diaminopurinenucleosides AT lewkowiczes microbialsynthesisof26diaminopurinenucleosides AT iribarrenam microbialsynthesisof26diaminopurinenucleosides
_version_	1782030944470827008

Microbial synthesis of 2,6-diaminopurine nucleosides

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