Benzimidazole as deazapurine analogue for microbial transglycosylation

Benzimidazole nucleosides are compounds with interesting pharmacological properties. Although chemical synthesis of these analogues has been carried out, only few derivatives have been obtained so far using biotransformations. We report herein the biocatalysed preparation of benzimidazole ribo- and...

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Autores principales:	Bentancor, L., Trelles, J.A., Nóbile, M., Lewkowicz, E.S., Iribarren, A.M.
Formato:	JOUR
Materias:	Benzimidazole Microbial transglycosylation Nucleoside analogues Whole cells Cells Derivatives Synthesis (chemical) Biotransformations Pharmacological properties Catalysis benzimidazole benzimidazole 2' deoxyriboside benzimidazole riboside purine derivative unclassified drug bacterial cell catalysis conference paper controlled study drug synthesis drug transformation glycosylation microorganism nonhuman
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_13811177_v29_n1-6_p3_Bentancor
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_13811177_v29_n1-6_p3_Bentancor
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spelling	todo:paper_13811177_v29_n1-6_p3_Bentancor2023-10-03T16:11:44Z Benzimidazole as deazapurine analogue for microbial transglycosylation Bentancor, L. Trelles, J.A. Nóbile, M. Lewkowicz, E.S. Iribarren, A.M. Benzimidazole Microbial transglycosylation Nucleoside analogues Whole cells Cells Derivatives Synthesis (chemical) Benzimidazole Biotransformations Pharmacological properties Catalysis benzimidazole benzimidazole 2' deoxyriboside benzimidazole riboside purine derivative unclassified drug bacterial cell catalysis conference paper controlled study drug synthesis drug transformation glycosylation microorganism nonhuman Benzimidazole nucleosides are compounds with interesting pharmacological properties. Although chemical synthesis of these analogues has been carried out, only few derivatives have been obtained so far using biotransformations. We report herein the biocatalysed preparation of benzimidazole ribo- and 2′-deoxyribonucleosides by different microbial whole cells that afforded yields between 75 and 85%. © 2004 Elsevier B.V. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_13811177_v29_n1-6_p3_Bentancor
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Benzimidazole Microbial transglycosylation Nucleoside analogues Whole cells Cells Derivatives Synthesis (chemical) Benzimidazole Biotransformations Pharmacological properties Catalysis benzimidazole benzimidazole 2' deoxyriboside benzimidazole riboside purine derivative unclassified drug bacterial cell catalysis conference paper controlled study drug synthesis drug transformation glycosylation microorganism nonhuman
spellingShingle	Benzimidazole Microbial transglycosylation Nucleoside analogues Whole cells Cells Derivatives Synthesis (chemical) Benzimidazole Biotransformations Pharmacological properties Catalysis benzimidazole benzimidazole 2' deoxyriboside benzimidazole riboside purine derivative unclassified drug bacterial cell catalysis conference paper controlled study drug synthesis drug transformation glycosylation microorganism nonhuman Bentancor, L. Trelles, J.A. Nóbile, M. Lewkowicz, E.S. Iribarren, A.M. Benzimidazole as deazapurine analogue for microbial transglycosylation
topic_facet	Benzimidazole Microbial transglycosylation Nucleoside analogues Whole cells Cells Derivatives Synthesis (chemical) Benzimidazole Biotransformations Pharmacological properties Catalysis benzimidazole benzimidazole 2' deoxyriboside benzimidazole riboside purine derivative unclassified drug bacterial cell catalysis conference paper controlled study drug synthesis drug transformation glycosylation microorganism nonhuman
description	Benzimidazole nucleosides are compounds with interesting pharmacological properties. Although chemical synthesis of these analogues has been carried out, only few derivatives have been obtained so far using biotransformations. We report herein the biocatalysed preparation of benzimidazole ribo- and 2′-deoxyribonucleosides by different microbial whole cells that afforded yields between 75 and 85%. © 2004 Elsevier B.V. All rights reserved.
format	JOUR
author	Bentancor, L. Trelles, J.A. Nóbile, M. Lewkowicz, E.S. Iribarren, A.M.
author_facet	Bentancor, L. Trelles, J.A. Nóbile, M. Lewkowicz, E.S. Iribarren, A.M.
author_sort	Bentancor, L.
title	Benzimidazole as deazapurine analogue for microbial transglycosylation
title_short	Benzimidazole as deazapurine analogue for microbial transglycosylation
title_full	Benzimidazole as deazapurine analogue for microbial transglycosylation
title_fullStr	Benzimidazole as deazapurine analogue for microbial transglycosylation
title_full_unstemmed	Benzimidazole as deazapurine analogue for microbial transglycosylation
title_sort	benzimidazole as deazapurine analogue for microbial transglycosylation
url	http://hdl.handle.net/20.500.12110/paper_13811177_v29_n1-6_p3_Bentancor
work_keys_str_mv	AT bentancorl benzimidazoleasdeazapurineanalogueformicrobialtransglycosylation AT trellesja benzimidazoleasdeazapurineanalogueformicrobialtransglycosylation AT nobilem benzimidazoleasdeazapurineanalogueformicrobialtransglycosylation AT lewkowiczes benzimidazoleasdeazapurineanalogueformicrobialtransglycosylation AT iribarrenam benzimidazoleasdeazapurineanalogueformicrobialtransglycosylation
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Benzimidazole as deazapurine analogue for microbial transglycosylation

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