Multiple links between transcription and splicing

Transcription and pre-mRNA splicing are extremely complex multimolecular processes that involve protein-DNA, protein-RNA, and protein-protein interactions. Splicing occurs in the close vicinity of genes and is frequently cotranscriptional. This is consistent with evidence that both processes are coo...

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Autores principales:	Kornblihtt, A.R., De La Mata, M., Fededa, J.P., Muñoz, M.J., Nogués, G.
Formato:	JOUR
Materias:	Alternative splicing Coupling RNA polymerase II Splicing Transcription cis acting element messenger RNA PGC 1 protein protein trans acting factor transcription factor unclassified drug alternative RNA splicing c terminal domain eukaryote gene gene expression gene expression regulation minigene polyadenylation priority journal protein DNA interaction protein domain protein protein interaction protein RNA binding review RNA capping RNA cleavage rna polyadenylation RNA processing RNA splicing RNA transcription RNA translation spliceosome transcription elongation transcription initiation transcription regulation Alternative Splicing Animals Humans Models, Biological Protein Subunits RNA Polymerase II RNA Precursors RNA Splicing Spliceosomes Trans-Activators Trans-Splicing Transcription, Genetic Eukaryota
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_13558382_v10_n10_p1489_Kornblihtt
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_13558382_v10_n10_p1489_Kornblihtt
record_format	dspace
spelling	todo:paper_13558382_v10_n10_p1489_Kornblihtt2023-10-03T16:10:23Z Multiple links between transcription and splicing Kornblihtt, A.R. De La Mata, M. Fededa, J.P. Muñoz, M.J. Nogués, G. Alternative splicing Coupling RNA polymerase II Splicing Transcription cis acting element messenger RNA PGC 1 protein protein RNA polymerase II trans acting factor transcription factor unclassified drug alternative RNA splicing c terminal domain eukaryote gene gene expression gene expression regulation minigene polyadenylation priority journal protein DNA interaction protein domain protein protein interaction protein RNA binding review RNA capping RNA cleavage rna polyadenylation RNA processing RNA splicing RNA transcription RNA translation spliceosome transcription elongation transcription initiation transcription regulation Alternative Splicing Animals Humans Models, Biological Protein Subunits RNA Polymerase II RNA Precursors RNA Splicing Spliceosomes Trans-Activators Trans-Splicing Transcription, Genetic Eukaryota Transcription and pre-mRNA splicing are extremely complex multimolecular processes that involve protein-DNA, protein-RNA, and protein-protein interactions. Splicing occurs in the close vicinity of genes and is frequently cotranscriptional. This is consistent with evidence that both processes are coordinated and, in some cases, functionally coupled. This review focuses on the roles of cis- and trans-acting factors that regulate transcription, on constitutive and alternative splicing. We also discuss possible functions in splicing of the C-terminal domain (CTD) of the RNA polymerase II (pol II) largest subunit, whose participation in other key pre-mRNA processing reactions (capping and cleavage/polyadenylation) is well documented. Recent evidence indicates that transcriptional elongation and splicing can be influenced reciprocally: Elongation rates control alternative splicing and splicing factors can, in turn, modulate pol II elongation. The presence of transcription factors in the spliceosome and the existence of proteins, such as the coactivator PGC-1, with dual activities in splicing and transcription can explain the links between both processes and add a new level of complexity to the regulation of gene expression in eukaryotes. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_13558382_v10_n10_p1489_Kornblihtt
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Alternative splicing Coupling RNA polymerase II Splicing Transcription cis acting element messenger RNA PGC 1 protein protein RNA polymerase II trans acting factor transcription factor unclassified drug alternative RNA splicing c terminal domain eukaryote gene gene expression gene expression regulation minigene polyadenylation priority journal protein DNA interaction protein domain protein protein interaction protein RNA binding review RNA capping RNA cleavage rna polyadenylation RNA processing RNA splicing RNA transcription RNA translation spliceosome transcription elongation transcription initiation transcription regulation Alternative Splicing Animals Humans Models, Biological Protein Subunits RNA Polymerase II RNA Precursors RNA Splicing Spliceosomes Trans-Activators Trans-Splicing Transcription, Genetic Eukaryota
spellingShingle	Alternative splicing Coupling RNA polymerase II Splicing Transcription cis acting element messenger RNA PGC 1 protein protein RNA polymerase II trans acting factor transcription factor unclassified drug alternative RNA splicing c terminal domain eukaryote gene gene expression gene expression regulation minigene polyadenylation priority journal protein DNA interaction protein domain protein protein interaction protein RNA binding review RNA capping RNA cleavage rna polyadenylation RNA processing RNA splicing RNA transcription RNA translation spliceosome transcription elongation transcription initiation transcription regulation Alternative Splicing Animals Humans Models, Biological Protein Subunits RNA Polymerase II RNA Precursors RNA Splicing Spliceosomes Trans-Activators Trans-Splicing Transcription, Genetic Eukaryota Kornblihtt, A.R. De La Mata, M. Fededa, J.P. Muñoz, M.J. Nogués, G. Multiple links between transcription and splicing
topic_facet	Alternative splicing Coupling RNA polymerase II Splicing Transcription cis acting element messenger RNA PGC 1 protein protein RNA polymerase II trans acting factor transcription factor unclassified drug alternative RNA splicing c terminal domain eukaryote gene gene expression gene expression regulation minigene polyadenylation priority journal protein DNA interaction protein domain protein protein interaction protein RNA binding review RNA capping RNA cleavage rna polyadenylation RNA processing RNA splicing RNA transcription RNA translation spliceosome transcription elongation transcription initiation transcription regulation Alternative Splicing Animals Humans Models, Biological Protein Subunits RNA Polymerase II RNA Precursors RNA Splicing Spliceosomes Trans-Activators Trans-Splicing Transcription, Genetic Eukaryota
description	Transcription and pre-mRNA splicing are extremely complex multimolecular processes that involve protein-DNA, protein-RNA, and protein-protein interactions. Splicing occurs in the close vicinity of genes and is frequently cotranscriptional. This is consistent with evidence that both processes are coordinated and, in some cases, functionally coupled. This review focuses on the roles of cis- and trans-acting factors that regulate transcription, on constitutive and alternative splicing. We also discuss possible functions in splicing of the C-terminal domain (CTD) of the RNA polymerase II (pol II) largest subunit, whose participation in other key pre-mRNA processing reactions (capping and cleavage/polyadenylation) is well documented. Recent evidence indicates that transcriptional elongation and splicing can be influenced reciprocally: Elongation rates control alternative splicing and splicing factors can, in turn, modulate pol II elongation. The presence of transcription factors in the spliceosome and the existence of proteins, such as the coactivator PGC-1, with dual activities in splicing and transcription can explain the links between both processes and add a new level of complexity to the regulation of gene expression in eukaryotes.
format	JOUR
author	Kornblihtt, A.R. De La Mata, M. Fededa, J.P. Muñoz, M.J. Nogués, G.
author_facet	Kornblihtt, A.R. De La Mata, M. Fededa, J.P. Muñoz, M.J. Nogués, G.
author_sort	Kornblihtt, A.R.
title	Multiple links between transcription and splicing
title_short	Multiple links between transcription and splicing
title_full	Multiple links between transcription and splicing
title_fullStr	Multiple links between transcription and splicing
title_full_unstemmed	Multiple links between transcription and splicing
title_sort	multiple links between transcription and splicing
url	http://hdl.handle.net/20.500.12110/paper_13558382_v10_n10_p1489_Kornblihtt
work_keys_str_mv	AT kornblihttar multiplelinksbetweentranscriptionandsplicing AT delamatam multiplelinksbetweentranscriptionandsplicing AT fededajp multiplelinksbetweentranscriptionandsplicing AT munozmj multiplelinksbetweentranscriptionandsplicing AT noguesg multiplelinksbetweentranscriptionandsplicing
_version_	1782027242160783360

Multiple links between transcription and splicing

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