Involvement of galectin-1 in reproduction: Past, present and future
background: After recognition of its pivotal contribution to fetomaternal tolerance, the study of galectin-1 (gal-1) functions in the context of pregnancy became an attractive topic in reproductive medicine. Despite considerable advances in the understanding of the immuno- and growth-regulatory prop...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_13554786_v20_n2_p175_Barrientos |
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todo:paper_13554786_v20_n2_p175_Barrientos2023-10-03T16:10:19Z Involvement of galectin-1 in reproduction: Past, present and future Barrientos, G. Freitag, N. Tirado-González, I. Unverdorben, L. Jeschke, U. Thijssen, V.L.J.L. Blois, S.M. Angiogenesis Cancer Galectin-1 Pregnancy Progesterone angiogenesis cancer galectin-1 pregnancy progesterone Adaptation, Physiological Animals Female Galectin 1 Genital Neoplasms, Female Genitalia, Female Humans Immune Tolerance Mice Neovascularization, Physiologic Pregnancy Pregnancy Complications Reproduction Signal Transduction Trophoblasts background: After recognition of its pivotal contribution to fetomaternal tolerance, the study of galectin-1 (gal-1) functions in the context of pregnancy became an attractive topic in reproductive medicine. Despite considerable advances in the understanding of the immuno- and growth-regulatory properties of gal-1 at the fetal-maternal interface, many functional aspects of this lectin in reproduction are only emerging. methods: The published literature was searched using Pubmed focusing on gal-1 signalling and functional properties at the maternal-fetal interface, including data on its implication in pregnancy disorders and malignancies of the female reproductive system. Papers discussing animal and human studies were included. results: This review provides an overview of gal-1 functions during pregnancy, such as modulation of maternal immune responses and roles in embryo implantation and placentation.We also emphasize the role of gal-1 in key regulatory processes, including trophoblast migration, invasion, syncytiumformation and expression of non-classical MHC class I molecules (HLA-G). In addition, we argue in favour of gal-1 pro-angiogenic properties, as observed in tumourigenesis and other pathological settings, and its implication in the angiogenesis process associated with early gestation. conclusion: The involvement of gal-1 in the regulation of different processes during the establishment, development and maintenance of pregnancy could be described as unique. Gal-1 has emerged as an important lectin with major functions in pregnancy. © The Author 2013. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_13554786_v20_n2_p175_Barrientos |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Angiogenesis Cancer Galectin-1 Pregnancy Progesterone angiogenesis cancer galectin-1 pregnancy progesterone Adaptation, Physiological Animals Female Galectin 1 Genital Neoplasms, Female Genitalia, Female Humans Immune Tolerance Mice Neovascularization, Physiologic Pregnancy Pregnancy Complications Reproduction Signal Transduction Trophoblasts |
| spellingShingle |
Angiogenesis Cancer Galectin-1 Pregnancy Progesterone angiogenesis cancer galectin-1 pregnancy progesterone Adaptation, Physiological Animals Female Galectin 1 Genital Neoplasms, Female Genitalia, Female Humans Immune Tolerance Mice Neovascularization, Physiologic Pregnancy Pregnancy Complications Reproduction Signal Transduction Trophoblasts Barrientos, G. Freitag, N. Tirado-González, I. Unverdorben, L. Jeschke, U. Thijssen, V.L.J.L. Blois, S.M. Involvement of galectin-1 in reproduction: Past, present and future |
| topic_facet |
Angiogenesis Cancer Galectin-1 Pregnancy Progesterone angiogenesis cancer galectin-1 pregnancy progesterone Adaptation, Physiological Animals Female Galectin 1 Genital Neoplasms, Female Genitalia, Female Humans Immune Tolerance Mice Neovascularization, Physiologic Pregnancy Pregnancy Complications Reproduction Signal Transduction Trophoblasts |
| description |
background: After recognition of its pivotal contribution to fetomaternal tolerance, the study of galectin-1 (gal-1) functions in the context of pregnancy became an attractive topic in reproductive medicine. Despite considerable advances in the understanding of the immuno- and growth-regulatory properties of gal-1 at the fetal-maternal interface, many functional aspects of this lectin in reproduction are only emerging. methods: The published literature was searched using Pubmed focusing on gal-1 signalling and functional properties at the maternal-fetal interface, including data on its implication in pregnancy disorders and malignancies of the female reproductive system. Papers discussing animal and human studies were included. results: This review provides an overview of gal-1 functions during pregnancy, such as modulation of maternal immune responses and roles in embryo implantation and placentation.We also emphasize the role of gal-1 in key regulatory processes, including trophoblast migration, invasion, syncytiumformation and expression of non-classical MHC class I molecules (HLA-G). In addition, we argue in favour of gal-1 pro-angiogenic properties, as observed in tumourigenesis and other pathological settings, and its implication in the angiogenesis process associated with early gestation. conclusion: The involvement of gal-1 in the regulation of different processes during the establishment, development and maintenance of pregnancy could be described as unique. Gal-1 has emerged as an important lectin with major functions in pregnancy. © The Author 2013. |
| format |
JOUR |
| author |
Barrientos, G. Freitag, N. Tirado-González, I. Unverdorben, L. Jeschke, U. Thijssen, V.L.J.L. Blois, S.M. |
| author_facet |
Barrientos, G. Freitag, N. Tirado-González, I. Unverdorben, L. Jeschke, U. Thijssen, V.L.J.L. Blois, S.M. |
| author_sort |
Barrientos, G. |
| title |
Involvement of galectin-1 in reproduction: Past, present and future |
| title_short |
Involvement of galectin-1 in reproduction: Past, present and future |
| title_full |
Involvement of galectin-1 in reproduction: Past, present and future |
| title_fullStr |
Involvement of galectin-1 in reproduction: Past, present and future |
| title_full_unstemmed |
Involvement of galectin-1 in reproduction: Past, present and future |
| title_sort |
involvement of galectin-1 in reproduction: past, present and future |
| url |
http://hdl.handle.net/20.500.12110/paper_13554786_v20_n2_p175_Barrientos |
| work_keys_str_mv |
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1807315887260172288 |