The role of inherited and acquired factors in the development of porphyria cutanea tarda in the Argentinean population.
BACKGROUND: Inherited and environmental factors are implicated in the expression of porphyria cutanea tarda (PCT); the contribution of each factor depends on the population. OBJECTIVE: To provide a review of PCT cases diagnosed in Argentina over 24 years and evaluate the role of different precipitat...
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todo:paper_10976787_v52_n3Pt1_p417_Mendez2023-10-03T16:05:31Z The role of inherited and acquired factors in the development of porphyria cutanea tarda in the Argentinean population. Méndez, M. Rossetti, M.V. Del C Batlle, A.M. Parera, V.E. hepatitis C antibody HFE protein, human HLA antigen class 1 membrane protein uroporphyrinogen decarboxylase adolescent adult aged Argentina article blood child epidemiology female genetics hepatitis C human male metabolism middle aged mutation onset age pathophysiology porphyria cutanea tarda retrospective study risk factor Adolescent Adult Age of Onset Aged Argentina Child Female Hepatitis C Hepatitis C Antibodies Histocompatibility Antigens Class I Humans Male Membrane Proteins Middle Aged Mutation Porphyria Cutanea Tarda Precipitating Factors Retrospective Studies Risk Factors Uroporphyrinogen Decarboxylase BACKGROUND: Inherited and environmental factors are implicated in the expression of porphyria cutanea tarda (PCT); the contribution of each factor depends on the population. OBJECTIVE: To provide a review of PCT cases diagnosed in Argentina over 24 years and evaluate the role of different precipitating factors in its pathogenesis. Methods Plasma and urinary porphyrin levels and erythrocyte uroporphyrinogen decarboxylase (URO-D) activity were determined. Potential precipitating factors were identified in each patient. Additional tests for hepatitis C virus (HCV) and hemochromatosis gene mutations were carried out. RESULTS: Several factors (mainly alcohol abuse in men and estrogen ingestion in women), alone or combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. CONCLUSIONS: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. Fil:Méndez, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Rossetti, M.V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Del C Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Parera, V.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10976787_v52_n3Pt1_p417_Mendez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
hepatitis C antibody HFE protein, human HLA antigen class 1 membrane protein uroporphyrinogen decarboxylase adolescent adult aged Argentina article blood child epidemiology female genetics hepatitis C human male metabolism middle aged mutation onset age pathophysiology porphyria cutanea tarda retrospective study risk factor Adolescent Adult Age of Onset Aged Argentina Child Female Hepatitis C Hepatitis C Antibodies Histocompatibility Antigens Class I Humans Male Membrane Proteins Middle Aged Mutation Porphyria Cutanea Tarda Precipitating Factors Retrospective Studies Risk Factors Uroporphyrinogen Decarboxylase |
| spellingShingle |
hepatitis C antibody HFE protein, human HLA antigen class 1 membrane protein uroporphyrinogen decarboxylase adolescent adult aged Argentina article blood child epidemiology female genetics hepatitis C human male metabolism middle aged mutation onset age pathophysiology porphyria cutanea tarda retrospective study risk factor Adolescent Adult Age of Onset Aged Argentina Child Female Hepatitis C Hepatitis C Antibodies Histocompatibility Antigens Class I Humans Male Membrane Proteins Middle Aged Mutation Porphyria Cutanea Tarda Precipitating Factors Retrospective Studies Risk Factors Uroporphyrinogen Decarboxylase Méndez, M. Rossetti, M.V. Del C Batlle, A.M. Parera, V.E. The role of inherited and acquired factors in the development of porphyria cutanea tarda in the Argentinean population. |
| topic_facet |
hepatitis C antibody HFE protein, human HLA antigen class 1 membrane protein uroporphyrinogen decarboxylase adolescent adult aged Argentina article blood child epidemiology female genetics hepatitis C human male metabolism middle aged mutation onset age pathophysiology porphyria cutanea tarda retrospective study risk factor Adolescent Adult Age of Onset Aged Argentina Child Female Hepatitis C Hepatitis C Antibodies Histocompatibility Antigens Class I Humans Male Membrane Proteins Middle Aged Mutation Porphyria Cutanea Tarda Precipitating Factors Retrospective Studies Risk Factors Uroporphyrinogen Decarboxylase |
| description |
BACKGROUND: Inherited and environmental factors are implicated in the expression of porphyria cutanea tarda (PCT); the contribution of each factor depends on the population. OBJECTIVE: To provide a review of PCT cases diagnosed in Argentina over 24 years and evaluate the role of different precipitating factors in its pathogenesis. Methods Plasma and urinary porphyrin levels and erythrocyte uroporphyrinogen decarboxylase (URO-D) activity were determined. Potential precipitating factors were identified in each patient. Additional tests for hepatitis C virus (HCV) and hemochromatosis gene mutations were carried out. RESULTS: Several factors (mainly alcohol abuse in men and estrogen ingestion in women), alone or combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. CONCLUSIONS: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. |
| format |
JOUR |
| author |
Méndez, M. Rossetti, M.V. Del C Batlle, A.M. Parera, V.E. |
| author_facet |
Méndez, M. Rossetti, M.V. Del C Batlle, A.M. Parera, V.E. |
| author_sort |
Méndez, M. |
| title |
The role of inherited and acquired factors in the development of porphyria cutanea tarda in the Argentinean population. |
| title_short |
The role of inherited and acquired factors in the development of porphyria cutanea tarda in the Argentinean population. |
| title_full |
The role of inherited and acquired factors in the development of porphyria cutanea tarda in the Argentinean population. |
| title_fullStr |
The role of inherited and acquired factors in the development of porphyria cutanea tarda in the Argentinean population. |
| title_full_unstemmed |
The role of inherited and acquired factors in the development of porphyria cutanea tarda in the Argentinean population. |
| title_sort |
role of inherited and acquired factors in the development of porphyria cutanea tarda in the argentinean population. |
| url |
http://hdl.handle.net/20.500.12110/paper_10976787_v52_n3Pt1_p417_Mendez |
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