Melatonin formation in pineal gland from rats with hexachlorobenzene experimental porphyria

Hexachlorobenzene produces an experimental hepatic porphyria in rats, which is similar to human porphyria cutanea tarda, with hyperpigmentation as one of its characteristic features. Alterations in tryptophan metabolism have been previously observed in this chronic porphyria. Melatonin formation fro...

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Autores principales:	Llambías, E.B.C., Mazzetti, M.B., Lelli, S.M., Aldonatti, C., De Viale, L.C.S.M.
Formato:	JOUR
Materias:	Experimental Hepatic Porphyria Hexachlorobenzene Melatonin Porphyria Cutanea Tarda Tryptophan Tryptophan Metabolites 5 hydroxyindoleacetic acid acetylserotonin methyltransferase hexachlorobenzene melatonin serotonin tryptophan animal experiment animal model animal tissue article controlled study enzyme activity female hyperpigmentation nonhuman oxidative stress pineal body porphyria cutanea tarda rat Acetylserotonin O-Methyltransferase Animals Circadian Rhythm Disease Models, Animal Female Hydroxyindoleacetic Acid Light Pineal Gland Rats Rats, Wistar Serotonin Tryptophan Hydroxylase Animalia Rattus
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_10915818_v26_n6_p545_Llambias
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_10915818_v26_n6_p545_Llambias2023-10-03T16:04:57Z Melatonin formation in pineal gland from rats with hexachlorobenzene experimental porphyria Llambías, E.B.C. Mazzetti, M.B. Lelli, S.M. Aldonatti, C. De Viale, L.C.S.M. Experimental Hepatic Porphyria Hexachlorobenzene Melatonin Porphyria Cutanea Tarda Tryptophan Tryptophan Metabolites 5 hydroxyindoleacetic acid acetylserotonin methyltransferase hexachlorobenzene melatonin serotonin tryptophan animal experiment animal model animal tissue article controlled study enzyme activity female hyperpigmentation nonhuman oxidative stress pineal body porphyria cutanea tarda rat Acetylserotonin O-Methyltransferase Animals Circadian Rhythm Disease Models, Animal Female Hexachlorobenzene Hydroxyindoleacetic Acid Light Melatonin Pineal Gland Porphyria Cutanea Tarda Rats Rats, Wistar Serotonin Tryptophan Tryptophan Hydroxylase Animalia Rattus Hexachlorobenzene produces an experimental hepatic porphyria in rats, which is similar to human porphyria cutanea tarda, with hyperpigmentation as one of its characteristic features. Alterations in tryptophan metabolism have been previously observed in this chronic porphyria. Melatonin formation from tryptophan via serotonin shows diurnal rhythmicity in the pineal gland, and higher values are observed during the dark phase of an imposed light-dark cycle. The purpose of this study was to determine the contents of tryptophan and its metabolites in pineal gland of normal and hexachlorobenzene-treated rats in order to find alterations potentially related to porphyria cutanea tarda. Results show that in animals with this experimental porphyria some tryptophan metabolite levels (serotonin and 5-hydroxyindoleacetic acid) increase only during the light period, whereas tryptophan content remained equal to the controls. Hydroxyindole-O-methyltransferase activity also increases by light in pineal gland from hexachlorobenzene-treated rats. On the other hand, tryptophan is converted to melatonin in the dark period, but this route is not exacerbated in hexachlorobenzene porphyria. The relevance of these alterations is discussed in relation to hyperpigmentation, neoplastic and oxidative stress processes associated with this porphyria. Copyright © American College of Toxicology. Fil:Llambías, E.B.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Mazzetti, M.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Lelli, S.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10915818_v26_n6_p545_Llambias
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Experimental Hepatic Porphyria Hexachlorobenzene Melatonin Porphyria Cutanea Tarda Tryptophan Tryptophan Metabolites 5 hydroxyindoleacetic acid acetylserotonin methyltransferase hexachlorobenzene melatonin serotonin tryptophan animal experiment animal model animal tissue article controlled study enzyme activity female hyperpigmentation nonhuman oxidative stress pineal body porphyria cutanea tarda rat Acetylserotonin O-Methyltransferase Animals Circadian Rhythm Disease Models, Animal Female Hexachlorobenzene Hydroxyindoleacetic Acid Light Melatonin Pineal Gland Porphyria Cutanea Tarda Rats Rats, Wistar Serotonin Tryptophan Tryptophan Hydroxylase Animalia Rattus
spellingShingle	Experimental Hepatic Porphyria Hexachlorobenzene Melatonin Porphyria Cutanea Tarda Tryptophan Tryptophan Metabolites 5 hydroxyindoleacetic acid acetylserotonin methyltransferase hexachlorobenzene melatonin serotonin tryptophan animal experiment animal model animal tissue article controlled study enzyme activity female hyperpigmentation nonhuman oxidative stress pineal body porphyria cutanea tarda rat Acetylserotonin O-Methyltransferase Animals Circadian Rhythm Disease Models, Animal Female Hexachlorobenzene Hydroxyindoleacetic Acid Light Melatonin Pineal Gland Porphyria Cutanea Tarda Rats Rats, Wistar Serotonin Tryptophan Tryptophan Hydroxylase Animalia Rattus Llambías, E.B.C. Mazzetti, M.B. Lelli, S.M. Aldonatti, C. De Viale, L.C.S.M. Melatonin formation in pineal gland from rats with hexachlorobenzene experimental porphyria
topic_facet	Experimental Hepatic Porphyria Hexachlorobenzene Melatonin Porphyria Cutanea Tarda Tryptophan Tryptophan Metabolites 5 hydroxyindoleacetic acid acetylserotonin methyltransferase hexachlorobenzene melatonin serotonin tryptophan animal experiment animal model animal tissue article controlled study enzyme activity female hyperpigmentation nonhuman oxidative stress pineal body porphyria cutanea tarda rat Acetylserotonin O-Methyltransferase Animals Circadian Rhythm Disease Models, Animal Female Hexachlorobenzene Hydroxyindoleacetic Acid Light Melatonin Pineal Gland Porphyria Cutanea Tarda Rats Rats, Wistar Serotonin Tryptophan Tryptophan Hydroxylase Animalia Rattus
description	Hexachlorobenzene produces an experimental hepatic porphyria in rats, which is similar to human porphyria cutanea tarda, with hyperpigmentation as one of its characteristic features. Alterations in tryptophan metabolism have been previously observed in this chronic porphyria. Melatonin formation from tryptophan via serotonin shows diurnal rhythmicity in the pineal gland, and higher values are observed during the dark phase of an imposed light-dark cycle. The purpose of this study was to determine the contents of tryptophan and its metabolites in pineal gland of normal and hexachlorobenzene-treated rats in order to find alterations potentially related to porphyria cutanea tarda. Results show that in animals with this experimental porphyria some tryptophan metabolite levels (serotonin and 5-hydroxyindoleacetic acid) increase only during the light period, whereas tryptophan content remained equal to the controls. Hydroxyindole-O-methyltransferase activity also increases by light in pineal gland from hexachlorobenzene-treated rats. On the other hand, tryptophan is converted to melatonin in the dark period, but this route is not exacerbated in hexachlorobenzene porphyria. The relevance of these alterations is discussed in relation to hyperpigmentation, neoplastic and oxidative stress processes associated with this porphyria. Copyright © American College of Toxicology.
format	JOUR
author	Llambías, E.B.C. Mazzetti, M.B. Lelli, S.M. Aldonatti, C. De Viale, L.C.S.M.
author_facet	Llambías, E.B.C. Mazzetti, M.B. Lelli, S.M. Aldonatti, C. De Viale, L.C.S.M.
author_sort	Llambías, E.B.C.
title	Melatonin formation in pineal gland from rats with hexachlorobenzene experimental porphyria
title_short	Melatonin formation in pineal gland from rats with hexachlorobenzene experimental porphyria
title_full	Melatonin formation in pineal gland from rats with hexachlorobenzene experimental porphyria
title_fullStr	Melatonin formation in pineal gland from rats with hexachlorobenzene experimental porphyria
title_full_unstemmed	Melatonin formation in pineal gland from rats with hexachlorobenzene experimental porphyria
title_sort	melatonin formation in pineal gland from rats with hexachlorobenzene experimental porphyria
url	http://hdl.handle.net/20.500.12110/paper_10915818_v26_n6_p545_Llambias
work_keys_str_mv	AT llambiasebc melatoninformationinpinealglandfromratswithhexachlorobenzeneexperimentalporphyria AT mazzettimb melatoninformationinpinealglandfromratswithhexachlorobenzeneexperimentalporphyria AT lellism melatoninformationinpinealglandfromratswithhexachlorobenzeneexperimentalporphyria AT aldonattic melatoninformationinpinealglandfromratswithhexachlorobenzeneexperimentalporphyria AT devialelcsm melatoninformationinpinealglandfromratswithhexachlorobenzeneexperimentalporphyria
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Melatonin formation in pineal gland from rats with hexachlorobenzene experimental porphyria

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