Quantum dot ligands provide new insights into erbB/HER receptor-mediated signal transduction

The erbB/HER family of transmembrane receptor tyrosine kinases (RTKs) mediate cellular responses to epidermal growth factor (EGF) and related ligands. We have imaged the early stages of RTK-dependent signaling in living cells using: (i) stable expression of erbB1/2/3 fused with visible fluorescent p...

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Detalles Bibliográficos
Autores principales:	Lidke, D.S., Nagy, P., Heintzmann, R., Arndt-Jovin, D.J., Post, J.N., Grecco, H.E., Jares-Erijman, E.A., Jovin, T.M.
Formato:	JOUR
Materias:	Cells Enzymes Semiconductor quantum dots Epidermal growth factors (EGF) Biotechnology citrine epidermal growth factor epidermal growth factor receptor epidermal growth factor receptor 2 epidermal growth factor receptor 3 fluorescent dye hybrid protein ligand monomer oligomer protein tyrosine kinase unclassified drug yellow fluorescent protein animal cell article biotechnology cell line cell strain A431 CHO cell confocal laser microscopy controlled study dimerization endocytosis endosome filopodium flow cytometry fluorescence human human cell internalization ligand binding nonhuman priority journal quantitative analysis quantum mechanics signal transduction Animals Cell Membrane Cricetinae Endosomes Epidermal Growth Factor Humans Motion Oncogene Proteins v-erbB Protein Binding Protein Interaction Mapping Protein Transport Quantum Dots Receptors, Cell Surface Signal Transduction Spectrometry, Fluorescence Animalia
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_10870156_v22_n2_p198_Lidke
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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