Information flow in the presence of cell mixing and signaling delays during embryonic development
Embryonic morphogenesis is organized by an interplay between intercellular signaling and cell movements. Both intercellular signaling and cell movement involve multiple timescales. A key timescale for signaling is the time delay caused by preparation of signaling molecules and integration of receive...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_10849521_v_n_p_Petrungaro |
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todo:paper_10849521_v_n_p_Petrungaro2023-10-03T16:04:14Z Information flow in the presence of cell mixing and signaling delays during embryonic development Petrungaro, G. Morelli, L.G. Uriu, K. Cell mixing Segmentation clock Signaling delays Synchronization Timescales article cell function embryo embryo development nonhuman signal transduction theoretical study zebra fish Embryonic morphogenesis is organized by an interplay between intercellular signaling and cell movements. Both intercellular signaling and cell movement involve multiple timescales. A key timescale for signaling is the time delay caused by preparation of signaling molecules and integration of received signals into cells’ internal state. Movement of cells relative to their neighbors may introduce exchange of positions between cells during signaling. When cells change their relative positions in a tissue, the impact of signaling delays on intercellular signaling increases because the delayed information that cells receive may significantly differ from the present state of the tissue. The time it takes to perform a neighbor exchange sets a timescale of cell mixing that may be important for the outcome of signaling. Here we review recent theoretical work on the interplay of timescales between cell mixing and signaling delays adopting the zebrafish segmentation clock as a model system. We discuss how this interplay can lead to spatial patterns of gene expression that could disrupt the normal formation of segment boundaries in the embryo. The effect of cell mixing and signaling delays highlights the importance of theoretical and experimental frameworks to understand collective cellular behaviors arising from the interplay of multiple timescales in embryonic developmental processes. © 2018 Elsevier Ltd INPR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10849521_v_n_p_Petrungaro |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Cell mixing Segmentation clock Signaling delays Synchronization Timescales article cell function embryo embryo development nonhuman signal transduction theoretical study zebra fish |
| spellingShingle |
Cell mixing Segmentation clock Signaling delays Synchronization Timescales article cell function embryo embryo development nonhuman signal transduction theoretical study zebra fish Petrungaro, G. Morelli, L.G. Uriu, K. Information flow in the presence of cell mixing and signaling delays during embryonic development |
| topic_facet |
Cell mixing Segmentation clock Signaling delays Synchronization Timescales article cell function embryo embryo development nonhuman signal transduction theoretical study zebra fish |
| description |
Embryonic morphogenesis is organized by an interplay between intercellular signaling and cell movements. Both intercellular signaling and cell movement involve multiple timescales. A key timescale for signaling is the time delay caused by preparation of signaling molecules and integration of received signals into cells’ internal state. Movement of cells relative to their neighbors may introduce exchange of positions between cells during signaling. When cells change their relative positions in a tissue, the impact of signaling delays on intercellular signaling increases because the delayed information that cells receive may significantly differ from the present state of the tissue. The time it takes to perform a neighbor exchange sets a timescale of cell mixing that may be important for the outcome of signaling. Here we review recent theoretical work on the interplay of timescales between cell mixing and signaling delays adopting the zebrafish segmentation clock as a model system. We discuss how this interplay can lead to spatial patterns of gene expression that could disrupt the normal formation of segment boundaries in the embryo. The effect of cell mixing and signaling delays highlights the importance of theoretical and experimental frameworks to understand collective cellular behaviors arising from the interplay of multiple timescales in embryonic developmental processes. © 2018 Elsevier Ltd |
| format |
INPR |
| author |
Petrungaro, G. Morelli, L.G. Uriu, K. |
| author_facet |
Petrungaro, G. Morelli, L.G. Uriu, K. |
| author_sort |
Petrungaro, G. |
| title |
Information flow in the presence of cell mixing and signaling delays during embryonic development |
| title_short |
Information flow in the presence of cell mixing and signaling delays during embryonic development |
| title_full |
Information flow in the presence of cell mixing and signaling delays during embryonic development |
| title_fullStr |
Information flow in the presence of cell mixing and signaling delays during embryonic development |
| title_full_unstemmed |
Information flow in the presence of cell mixing and signaling delays during embryonic development |
| title_sort |
information flow in the presence of cell mixing and signaling delays during embryonic development |
| url |
http://hdl.handle.net/20.500.12110/paper_10849521_v_n_p_Petrungaro |
| work_keys_str_mv |
AT petrungarog informationflowinthepresenceofcellmixingandsignalingdelaysduringembryonicdevelopment AT morellilg informationflowinthepresenceofcellmixingandsignalingdelaysduringembryonicdevelopment AT uriuk informationflowinthepresenceofcellmixingandsignalingdelaysduringembryonicdevelopment |
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1807314787053338624 |