Perinatal inflammation and adult psychopathology: From preclinical models to humans
Perinatal environment plays a crucial role in brain development and determines its function through life. Epidemiological studies and clinical reports link perinatal exposure to infection and/or immune activation to various psychiatric disorders. In addition, accumulating evidence from animal models...
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todo:paper_10849521_v77_n_p104_Depino2023-10-03T16:04:14Z Perinatal inflammation and adult psychopathology: From preclinical models to humans Depino, A.M. Anxiety Autism Depression Perinatal inflammation Psychiatric disease Rodent Schizophrenia adult anxiety autism brain development brain function depression disease predisposition environmental factor epigenetics gene expression glia human immune system inflammation maternal nutrition mental disease newborn nonhuman obesity perinatal morbidity preclinical study Review schizophrenia stress animal autism behavior brain depression female growth, development and aging inflammation mental disease mouse pathology physiology pregnancy pregnancy complication psychology rat schizophrenia Animals Anxiety Autistic Disorder Behavior Brain Depression Female Humans Inflammation Mental Disorders Mice Pregnancy Pregnancy Complications, Infectious Psychopathology Rats Schizophrenia Perinatal environment plays a crucial role in brain development and determines its function through life. Epidemiological studies and clinical reports link perinatal exposure to infection and/or immune activation to various psychiatric disorders. In addition, accumulating evidence from animal models shows that perinatal inflammation can affect various behaviors relevant to psychiatric disorders such as schizophrenia, autism, anxiety and depression. Remarkably, the effects on behavior and brain function do not always depend on the type of inflammatory stimulus or the perinatal age targeted, so diverse inflammatory events can have similar consequences on the brain. Moreover, other perinatal environmental factors that affect behavior (e.g. diet and stress) also elicit inflammatory responses. Understanding the interplay between perinatal environment and inflammation on brain development is required to identify the mechanisms through which perinatal inflammation affect brain function in the adult animal. Evidence for the role of the peripheral immune system and glia on perinatal programming of behavior is discussed in this review, along with recent evidence for the role of epigenetic mechanisms affecting gene expression in the brain. © 2017 Elsevier Ltd JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10849521_v77_n_p104_Depino |
| institution |
Universidad de Buenos Aires |
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I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Anxiety Autism Depression Perinatal inflammation Psychiatric disease Rodent Schizophrenia adult anxiety autism brain development brain function depression disease predisposition environmental factor epigenetics gene expression glia human immune system inflammation maternal nutrition mental disease newborn nonhuman obesity perinatal morbidity preclinical study Review schizophrenia stress animal autism behavior brain depression female growth, development and aging inflammation mental disease mouse pathology physiology pregnancy pregnancy complication psychology rat schizophrenia Animals Anxiety Autistic Disorder Behavior Brain Depression Female Humans Inflammation Mental Disorders Mice Pregnancy Pregnancy Complications, Infectious Psychopathology Rats Schizophrenia |
| spellingShingle |
Anxiety Autism Depression Perinatal inflammation Psychiatric disease Rodent Schizophrenia adult anxiety autism brain development brain function depression disease predisposition environmental factor epigenetics gene expression glia human immune system inflammation maternal nutrition mental disease newborn nonhuman obesity perinatal morbidity preclinical study Review schizophrenia stress animal autism behavior brain depression female growth, development and aging inflammation mental disease mouse pathology physiology pregnancy pregnancy complication psychology rat schizophrenia Animals Anxiety Autistic Disorder Behavior Brain Depression Female Humans Inflammation Mental Disorders Mice Pregnancy Pregnancy Complications, Infectious Psychopathology Rats Schizophrenia Depino, A.M. Perinatal inflammation and adult psychopathology: From preclinical models to humans |
| topic_facet |
Anxiety Autism Depression Perinatal inflammation Psychiatric disease Rodent Schizophrenia adult anxiety autism brain development brain function depression disease predisposition environmental factor epigenetics gene expression glia human immune system inflammation maternal nutrition mental disease newborn nonhuman obesity perinatal morbidity preclinical study Review schizophrenia stress animal autism behavior brain depression female growth, development and aging inflammation mental disease mouse pathology physiology pregnancy pregnancy complication psychology rat schizophrenia Animals Anxiety Autistic Disorder Behavior Brain Depression Female Humans Inflammation Mental Disorders Mice Pregnancy Pregnancy Complications, Infectious Psychopathology Rats Schizophrenia |
| description |
Perinatal environment plays a crucial role in brain development and determines its function through life. Epidemiological studies and clinical reports link perinatal exposure to infection and/or immune activation to various psychiatric disorders. In addition, accumulating evidence from animal models shows that perinatal inflammation can affect various behaviors relevant to psychiatric disorders such as schizophrenia, autism, anxiety and depression. Remarkably, the effects on behavior and brain function do not always depend on the type of inflammatory stimulus or the perinatal age targeted, so diverse inflammatory events can have similar consequences on the brain. Moreover, other perinatal environmental factors that affect behavior (e.g. diet and stress) also elicit inflammatory responses. Understanding the interplay between perinatal environment and inflammation on brain development is required to identify the mechanisms through which perinatal inflammation affect brain function in the adult animal. Evidence for the role of the peripheral immune system and glia on perinatal programming of behavior is discussed in this review, along with recent evidence for the role of epigenetic mechanisms affecting gene expression in the brain. © 2017 Elsevier Ltd |
| format |
JOUR |
| author |
Depino, A.M. |
| author_facet |
Depino, A.M. |
| author_sort |
Depino, A.M. |
| title |
Perinatal inflammation and adult psychopathology: From preclinical models to humans |
| title_short |
Perinatal inflammation and adult psychopathology: From preclinical models to humans |
| title_full |
Perinatal inflammation and adult psychopathology: From preclinical models to humans |
| title_fullStr |
Perinatal inflammation and adult psychopathology: From preclinical models to humans |
| title_full_unstemmed |
Perinatal inflammation and adult psychopathology: From preclinical models to humans |
| title_sort |
perinatal inflammation and adult psychopathology: from preclinical models to humans |
| url |
http://hdl.handle.net/20.500.12110/paper_10849521_v77_n_p104_Depino |
| work_keys_str_mv |
AT depinoam perinatalinflammationandadultpsychopathologyfrompreclinicalmodelstohumans |
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1782030098007851008 |