Factors associated with disability in patients with rheumatoid arthritis
OBJECTIVE:: Analyze disability determinants in a cohort of Argentine patients with rheumatoid arthritis (RA). MATERIAL AND METHODS:: Consecutive patients with RA, according to ACR87 criteria, were recruited from 6 rheumatology centers. Demographic and socioeconomic data, family history, comorbid dis...
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todo:paper_10761608_v16_n5_p215_Schneeberger2023-10-03T16:03:21Z Factors associated with disability in patients with rheumatoid arthritis Schneeberger, E.E. Citera, G. Maldonado Cocco, J.A. Salcedo, M. Chiardola, F. Rosemffet, M.G. Marengo, M.F. Papasidero, S. Chaparro Del Moral, R. Rillo, O.L. Bellomio, V. Lucero, E. Spindler, A. Berman, A. Duartes Noe, D. Barreira, J.C. Lázaro, M.A. Paira, S.O. discapacity disease activity rheumatoid arthritis adult Argentina article comorbidity controlled study demography dependent variable disability disease activity disease duration family history female functional status Health Assessment Questionnaire human major clinical study male multiple linear regression analysis priority journal radiography rheumatoid arthritis socioeconomics Adult Antirheumatic Agents Argentina Arthritis, Rheumatoid Cohort Studies Comorbidity Disability Evaluation Disease Progression Female Foot Joints Hand Joints Health Surveys Humans Logistic Models Male Middle Aged Severity of Illness Index OBJECTIVE:: Analyze disability determinants in a cohort of Argentine patients with rheumatoid arthritis (RA). MATERIAL AND METHODS:: Consecutive patients with RA, according to ACR87 criteria, were recruited from 6 rheumatology centers. Demographic and socioeconomic data, family history, comorbid diseases, extra-articular manifestations and information about received treatments were provided. Disease activity was assessed using Disease Activity Score 28 (DAS 28) and the Health Assessment Questionnaire (HAQ)-A was used for the functional capacity. Hand and feet radiographs were assessed using Sharp-van der Heijde score. RESULTS:: A total of 640 patients with RA were included, of which 85.2% were females. Mean age was 53 years (interquartile range [IQR], 44-62) and mean disease duration was 8 years (IQR, 4-14). DAS 28 mean was 2.72 (IQR, 1.7-3.7) and HAQ-A mean was 0.62 (IQR, 0.13-1.25). Multiple linear regression showed that the main variables associated with disability were DAS 28, radiologic damage and age. Main predictors of functional disability in the multiple logistic regression using severe HAQ (>2) as dependent variable were DAS 28 (OR, 2; P < 0.0001); age (OR, 1; P = 0.008); and structural damage (OR, 1; P = 0.001). CONCLUSIONS:: In this population, the disease activity was the variable that showed the highest impact on the physical function. Radiologic damage affected HAQ as the disease progressed. © 2010 by Lippincott Williams & Wilkins. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10761608_v16_n5_p215_Schneeberger |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
discapacity disease activity rheumatoid arthritis adult Argentina article comorbidity controlled study demography dependent variable disability disease activity disease duration family history female functional status Health Assessment Questionnaire human major clinical study male multiple linear regression analysis priority journal radiography rheumatoid arthritis socioeconomics Adult Antirheumatic Agents Argentina Arthritis, Rheumatoid Cohort Studies Comorbidity Disability Evaluation Disease Progression Female Foot Joints Hand Joints Health Surveys Humans Logistic Models Male Middle Aged Severity of Illness Index |
| spellingShingle |
discapacity disease activity rheumatoid arthritis adult Argentina article comorbidity controlled study demography dependent variable disability disease activity disease duration family history female functional status Health Assessment Questionnaire human major clinical study male multiple linear regression analysis priority journal radiography rheumatoid arthritis socioeconomics Adult Antirheumatic Agents Argentina Arthritis, Rheumatoid Cohort Studies Comorbidity Disability Evaluation Disease Progression Female Foot Joints Hand Joints Health Surveys Humans Logistic Models Male Middle Aged Severity of Illness Index Schneeberger, E.E. Citera, G. Maldonado Cocco, J.A. Salcedo, M. Chiardola, F. Rosemffet, M.G. Marengo, M.F. Papasidero, S. Chaparro Del Moral, R. Rillo, O.L. Bellomio, V. Lucero, E. Spindler, A. Berman, A. Duartes Noe, D. Barreira, J.C. Lázaro, M.A. Paira, S.O. Factors associated with disability in patients with rheumatoid arthritis |
| topic_facet |
discapacity disease activity rheumatoid arthritis adult Argentina article comorbidity controlled study demography dependent variable disability disease activity disease duration family history female functional status Health Assessment Questionnaire human major clinical study male multiple linear regression analysis priority journal radiography rheumatoid arthritis socioeconomics Adult Antirheumatic Agents Argentina Arthritis, Rheumatoid Cohort Studies Comorbidity Disability Evaluation Disease Progression Female Foot Joints Hand Joints Health Surveys Humans Logistic Models Male Middle Aged Severity of Illness Index |
| description |
OBJECTIVE:: Analyze disability determinants in a cohort of Argentine patients with rheumatoid arthritis (RA). MATERIAL AND METHODS:: Consecutive patients with RA, according to ACR87 criteria, were recruited from 6 rheumatology centers. Demographic and socioeconomic data, family history, comorbid diseases, extra-articular manifestations and information about received treatments were provided. Disease activity was assessed using Disease Activity Score 28 (DAS 28) and the Health Assessment Questionnaire (HAQ)-A was used for the functional capacity. Hand and feet radiographs were assessed using Sharp-van der Heijde score. RESULTS:: A total of 640 patients with RA were included, of which 85.2% were females. Mean age was 53 years (interquartile range [IQR], 44-62) and mean disease duration was 8 years (IQR, 4-14). DAS 28 mean was 2.72 (IQR, 1.7-3.7) and HAQ-A mean was 0.62 (IQR, 0.13-1.25). Multiple linear regression showed that the main variables associated with disability were DAS 28, radiologic damage and age. Main predictors of functional disability in the multiple logistic regression using severe HAQ (>2) as dependent variable were DAS 28 (OR, 2; P < 0.0001); age (OR, 1; P = 0.008); and structural damage (OR, 1; P = 0.001). CONCLUSIONS:: In this population, the disease activity was the variable that showed the highest impact on the physical function. Radiologic damage affected HAQ as the disease progressed. © 2010 by Lippincott Williams & Wilkins. |
| format |
JOUR |
| author |
Schneeberger, E.E. Citera, G. Maldonado Cocco, J.A. Salcedo, M. Chiardola, F. Rosemffet, M.G. Marengo, M.F. Papasidero, S. Chaparro Del Moral, R. Rillo, O.L. Bellomio, V. Lucero, E. Spindler, A. Berman, A. Duartes Noe, D. Barreira, J.C. Lázaro, M.A. Paira, S.O. |
| author_facet |
Schneeberger, E.E. Citera, G. Maldonado Cocco, J.A. Salcedo, M. Chiardola, F. Rosemffet, M.G. Marengo, M.F. Papasidero, S. Chaparro Del Moral, R. Rillo, O.L. Bellomio, V. Lucero, E. Spindler, A. Berman, A. Duartes Noe, D. Barreira, J.C. Lázaro, M.A. Paira, S.O. |
| author_sort |
Schneeberger, E.E. |
| title |
Factors associated with disability in patients with rheumatoid arthritis |
| title_short |
Factors associated with disability in patients with rheumatoid arthritis |
| title_full |
Factors associated with disability in patients with rheumatoid arthritis |
| title_fullStr |
Factors associated with disability in patients with rheumatoid arthritis |
| title_full_unstemmed |
Factors associated with disability in patients with rheumatoid arthritis |
| title_sort |
factors associated with disability in patients with rheumatoid arthritis |
| url |
http://hdl.handle.net/20.500.12110/paper_10761608_v16_n5_p215_Schneeberger |
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