Audiovestibular disorders in patients with ankylosing spondylitis

Objective: Audiovestibular disorders have been described in several autoimmune diseases but have not been studied in patients with ankylosing spondylitis (AS). The aim of this study was to evaluate the audiovestibular function in patients with AS. Methods: We prospectively evaluated 22 consecutive p...

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Autores principales:	Casellini, C., Citera, G., Rosemffet, M., Ruggeri, S., Saviotti, A., Maldonado Cocco, J.A.
Formato:	JOUR
Materias:	Ankylosing spondylitis Audiovestibular disorders Otosclerosis Sensorineural hearing loss methotrexate salazosulfapyridine salicylic acid derivative steroid adult ankylosing spondylitis article audiometry auditory nervous system autoimmune disease clinical article comorbidity controlled study disease activity female hearing disorder human hypoacusis male otosclerosis priority journal tympanometry vestibular disorder vestibular function Adult Age Factors Aged Audiometry Case-Control Studies Cochlear Nerve Female Hearing Loss, Sensorineural Humans Male Middle Aged Prospective Studies Spondylitis, Ankylosing Vestibular Nerve
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_10761608_v11_n2_p81_Casellini
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_10761608_v11_n2_p81_Casellini2023-10-03T16:03:20Z Audiovestibular disorders in patients with ankylosing spondylitis Casellini, C. Citera, G. Rosemffet, M. Ruggeri, S. Saviotti, A. Maldonado Cocco, J.A. Ankylosing spondylitis Audiovestibular disorders Otosclerosis Sensorineural hearing loss methotrexate salazosulfapyridine salicylic acid derivative steroid adult ankylosing spondylitis article audiometry auditory nervous system autoimmune disease clinical article comorbidity controlled study disease activity female hearing disorder human hypoacusis male otosclerosis priority journal tympanometry vestibular disorder vestibular function Adult Age Factors Aged Audiometry Case-Control Studies Cochlear Nerve Female Hearing Loss, Sensorineural Humans Male Middle Aged Otosclerosis Prospective Studies Spondylitis, Ankylosing Vestibular Nerve Objective: Audiovestibular disorders have been described in several autoimmune diseases but have not been studied in patients with ankylosing spondylitis (AS). The aim of this study was to evaluate the audiovestibular function in patients with AS. Methods: We prospectively evaluated 22 consecutive patients with AS. Clinical, radiologic, and immunogenetic features were analyzed. All patients underwent a complete ear, nose, and throat physical examination and audiologic evaluation that included pure-tone audiometry thresholds at octave frequencies of 250 to 8000 Hz, impedance audiometry (tympanogram, static compliance, acoustic reflexes, and reflex decay), and speech audiometry. Thirty-one healthy volunteers and 26 patients with rheumatoid arthritis (RA) were included as controls. Results: Patients with AS had a median age of 45.5 years (interquartile range [IQR] 38-54) and a median disease duration of 20 years (IQR 12.5-26.2). Otosclerosis was observed in 2 patients with AS (9.1%), 3 patients with RA (11.5%), but not in any healthy controls (P = not significant). Sensorineural hearing loss (SNHL) was observed in 13 patients with AS (59%), 17 patients with RA (65.4%), and 13 healthy controls (41.9%) without statistically significant differences. Because age can influence audiometric results, patients and controls were divided into 4 age groups. A higher frequency of SNHL was observed in patients with AS from 45 to 59 years compared with healthy controls and patients with RA (87% versus 20%, P = 0.03, versus 70%, P = not significant, respectively). Conclusion: Middle-aged patients with AS had a significantly higher frequency of SNHL compared with controls. SNHL should be considered as a possible complication of AS as well as of RA and other autoimmune diseases. Possible toxic effect of nonsteroidal antiinflammatory drugs should also be considered in such patients. Copyright © 2005 by Lippincott Williams & Wilkins. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10761608_v11_n2_p81_Casellini
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Ankylosing spondylitis Audiovestibular disorders Otosclerosis Sensorineural hearing loss methotrexate salazosulfapyridine salicylic acid derivative steroid adult ankylosing spondylitis article audiometry auditory nervous system autoimmune disease clinical article comorbidity controlled study disease activity female hearing disorder human hypoacusis male otosclerosis priority journal tympanometry vestibular disorder vestibular function Adult Age Factors Aged Audiometry Case-Control Studies Cochlear Nerve Female Hearing Loss, Sensorineural Humans Male Middle Aged Otosclerosis Prospective Studies Spondylitis, Ankylosing Vestibular Nerve
spellingShingle	Ankylosing spondylitis Audiovestibular disorders Otosclerosis Sensorineural hearing loss methotrexate salazosulfapyridine salicylic acid derivative steroid adult ankylosing spondylitis article audiometry auditory nervous system autoimmune disease clinical article comorbidity controlled study disease activity female hearing disorder human hypoacusis male otosclerosis priority journal tympanometry vestibular disorder vestibular function Adult Age Factors Aged Audiometry Case-Control Studies Cochlear Nerve Female Hearing Loss, Sensorineural Humans Male Middle Aged Otosclerosis Prospective Studies Spondylitis, Ankylosing Vestibular Nerve Casellini, C. Citera, G. Rosemffet, M. Ruggeri, S. Saviotti, A. Maldonado Cocco, J.A. Audiovestibular disorders in patients with ankylosing spondylitis
topic_facet	Ankylosing spondylitis Audiovestibular disorders Otosclerosis Sensorineural hearing loss methotrexate salazosulfapyridine salicylic acid derivative steroid adult ankylosing spondylitis article audiometry auditory nervous system autoimmune disease clinical article comorbidity controlled study disease activity female hearing disorder human hypoacusis male otosclerosis priority journal tympanometry vestibular disorder vestibular function Adult Age Factors Aged Audiometry Case-Control Studies Cochlear Nerve Female Hearing Loss, Sensorineural Humans Male Middle Aged Otosclerosis Prospective Studies Spondylitis, Ankylosing Vestibular Nerve
description	Objective: Audiovestibular disorders have been described in several autoimmune diseases but have not been studied in patients with ankylosing spondylitis (AS). The aim of this study was to evaluate the audiovestibular function in patients with AS. Methods: We prospectively evaluated 22 consecutive patients with AS. Clinical, radiologic, and immunogenetic features were analyzed. All patients underwent a complete ear, nose, and throat physical examination and audiologic evaluation that included pure-tone audiometry thresholds at octave frequencies of 250 to 8000 Hz, impedance audiometry (tympanogram, static compliance, acoustic reflexes, and reflex decay), and speech audiometry. Thirty-one healthy volunteers and 26 patients with rheumatoid arthritis (RA) were included as controls. Results: Patients with AS had a median age of 45.5 years (interquartile range [IQR] 38-54) and a median disease duration of 20 years (IQR 12.5-26.2). Otosclerosis was observed in 2 patients with AS (9.1%), 3 patients with RA (11.5%), but not in any healthy controls (P = not significant). Sensorineural hearing loss (SNHL) was observed in 13 patients with AS (59%), 17 patients with RA (65.4%), and 13 healthy controls (41.9%) without statistically significant differences. Because age can influence audiometric results, patients and controls were divided into 4 age groups. A higher frequency of SNHL was observed in patients with AS from 45 to 59 years compared with healthy controls and patients with RA (87% versus 20%, P = 0.03, versus 70%, P = not significant, respectively). Conclusion: Middle-aged patients with AS had a significantly higher frequency of SNHL compared with controls. SNHL should be considered as a possible complication of AS as well as of RA and other autoimmune diseases. Possible toxic effect of nonsteroidal antiinflammatory drugs should also be considered in such patients. Copyright © 2005 by Lippincott Williams & Wilkins.
format	JOUR
author	Casellini, C. Citera, G. Rosemffet, M. Ruggeri, S. Saviotti, A. Maldonado Cocco, J.A.
author_facet	Casellini, C. Citera, G. Rosemffet, M. Ruggeri, S. Saviotti, A. Maldonado Cocco, J.A.
author_sort	Casellini, C.
title	Audiovestibular disorders in patients with ankylosing spondylitis
title_short	Audiovestibular disorders in patients with ankylosing spondylitis
title_full	Audiovestibular disorders in patients with ankylosing spondylitis
title_fullStr	Audiovestibular disorders in patients with ankylosing spondylitis
title_full_unstemmed	Audiovestibular disorders in patients with ankylosing spondylitis
title_sort	audiovestibular disorders in patients with ankylosing spondylitis
url	http://hdl.handle.net/20.500.12110/paper_10761608_v11_n2_p81_Casellini
work_keys_str_mv	AT casellinic audiovestibulardisordersinpatientswithankylosingspondylitis AT citerag audiovestibulardisordersinpatientswithankylosingspondylitis AT rosemffetm audiovestibulardisordersinpatientswithankylosingspondylitis AT ruggeris audiovestibulardisordersinpatientswithankylosingspondylitis AT saviottia audiovestibulardisordersinpatientswithankylosingspondylitis AT maldonadococcoja audiovestibulardisordersinpatientswithankylosingspondylitis
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Audiovestibular disorders in patients with ankylosing spondylitis

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