Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer
Numerous regulatory programs have been identified that contribute to the restoration of homeostasis at the conclusion of immune responses and to safeguarding against the detrimental effects of chronic inflammation and autoimmune pathology. Malignant cells may usurp these pathways to create immunosup...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_10747613_v36_n3_p322_Rabinovich |
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todo:paper_10747613_v36_n3_p322_Rabinovich2023-10-03T16:03:09Z Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer Rabinovich, G. Croci, D.O. carcinoembryonic antigen related cell adhesion molecule 1 CD22 antigen cytotoxic T lymphocyte antigen 4 dectin 1 galectin glycan glycosidase glycosyltransferase immunoglobulin interleukin 10 interleukin 12 interleukin 6 lectin mitogen activated protein kinase protein tyrosine kinase tumor necrosis factor receptor 1 antigen presenting cell autoimmune disease autoimmunity carbohydrate synthesis cell death cell migration cell survival cytokine production endocytosis enzyme activation glycosylation immune response immunocompetent cell immunological tolerance inflammation lymphocyte activation neoplasm priority journal protein interaction protein motif protein phosphorylation protein structure regulatory mechanism regulatory T lymphocyte review Animals Antigen-Presenting Cells Autoimmunity Cell Death Humans Immune Tolerance Inflammation Lectins Lymphocyte Activation Mice Models, Immunological Neoplasms Polysaccharides Signal Transduction T-Lymphocytes Numerous regulatory programs have been identified that contribute to the restoration of homeostasis at the conclusion of immune responses and to safeguarding against the detrimental effects of chronic inflammation and autoimmune pathology. Malignant cells may usurp these pathways to create immunosuppressive networks that thwart antitumor responses. Herein we review the role of endogenous lectins (C-type lectins, siglecs, and galectins) and specific N- and O-glycans generated by the coordinated action of glycosyltransferases and glycosidases that together promote regulatory signals that control immune cell homeostasis. We also discuss the mechanisms by which glycan-dependent regulatory programs integrate into canonical circuits that amplify or silence immune responses related to autoimmunity and neoplastic disease. © 2012 Elsevier Inc.. Fil:Croci, D.O. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10747613_v36_n3_p322_Rabinovich |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
carcinoembryonic antigen related cell adhesion molecule 1 CD22 antigen cytotoxic T lymphocyte antigen 4 dectin 1 galectin glycan glycosidase glycosyltransferase immunoglobulin interleukin 10 interleukin 12 interleukin 6 lectin mitogen activated protein kinase protein tyrosine kinase tumor necrosis factor receptor 1 antigen presenting cell autoimmune disease autoimmunity carbohydrate synthesis cell death cell migration cell survival cytokine production endocytosis enzyme activation glycosylation immune response immunocompetent cell immunological tolerance inflammation lymphocyte activation neoplasm priority journal protein interaction protein motif protein phosphorylation protein structure regulatory mechanism regulatory T lymphocyte review Animals Antigen-Presenting Cells Autoimmunity Cell Death Humans Immune Tolerance Inflammation Lectins Lymphocyte Activation Mice Models, Immunological Neoplasms Polysaccharides Signal Transduction T-Lymphocytes |
| spellingShingle |
carcinoembryonic antigen related cell adhesion molecule 1 CD22 antigen cytotoxic T lymphocyte antigen 4 dectin 1 galectin glycan glycosidase glycosyltransferase immunoglobulin interleukin 10 interleukin 12 interleukin 6 lectin mitogen activated protein kinase protein tyrosine kinase tumor necrosis factor receptor 1 antigen presenting cell autoimmune disease autoimmunity carbohydrate synthesis cell death cell migration cell survival cytokine production endocytosis enzyme activation glycosylation immune response immunocompetent cell immunological tolerance inflammation lymphocyte activation neoplasm priority journal protein interaction protein motif protein phosphorylation protein structure regulatory mechanism regulatory T lymphocyte review Animals Antigen-Presenting Cells Autoimmunity Cell Death Humans Immune Tolerance Inflammation Lectins Lymphocyte Activation Mice Models, Immunological Neoplasms Polysaccharides Signal Transduction T-Lymphocytes Rabinovich, G. Croci, D.O. Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer |
| topic_facet |
carcinoembryonic antigen related cell adhesion molecule 1 CD22 antigen cytotoxic T lymphocyte antigen 4 dectin 1 galectin glycan glycosidase glycosyltransferase immunoglobulin interleukin 10 interleukin 12 interleukin 6 lectin mitogen activated protein kinase protein tyrosine kinase tumor necrosis factor receptor 1 antigen presenting cell autoimmune disease autoimmunity carbohydrate synthesis cell death cell migration cell survival cytokine production endocytosis enzyme activation glycosylation immune response immunocompetent cell immunological tolerance inflammation lymphocyte activation neoplasm priority journal protein interaction protein motif protein phosphorylation protein structure regulatory mechanism regulatory T lymphocyte review Animals Antigen-Presenting Cells Autoimmunity Cell Death Humans Immune Tolerance Inflammation Lectins Lymphocyte Activation Mice Models, Immunological Neoplasms Polysaccharides Signal Transduction T-Lymphocytes |
| description |
Numerous regulatory programs have been identified that contribute to the restoration of homeostasis at the conclusion of immune responses and to safeguarding against the detrimental effects of chronic inflammation and autoimmune pathology. Malignant cells may usurp these pathways to create immunosuppressive networks that thwart antitumor responses. Herein we review the role of endogenous lectins (C-type lectins, siglecs, and galectins) and specific N- and O-glycans generated by the coordinated action of glycosyltransferases and glycosidases that together promote regulatory signals that control immune cell homeostasis. We also discuss the mechanisms by which glycan-dependent regulatory programs integrate into canonical circuits that amplify or silence immune responses related to autoimmunity and neoplastic disease. © 2012 Elsevier Inc.. |
| format |
JOUR |
| author |
Rabinovich, G. Croci, D.O. |
| author_facet |
Rabinovich, G. Croci, D.O. |
| author_sort |
Rabinovich, G. |
| title |
Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer |
| title_short |
Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer |
| title_full |
Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer |
| title_fullStr |
Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer |
| title_full_unstemmed |
Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer |
| title_sort |
regulatory circuits mediated by lectin-glycan interactions in autoimmunity and cancer |
| url |
http://hdl.handle.net/20.500.12110/paper_10747613_v36_n3_p322_Rabinovich |
| work_keys_str_mv |
AT rabinovichg regulatorycircuitsmediatedbylectinglycaninteractionsinautoimmunityandcancer AT crocido regulatorycircuitsmediatedbylectinglycaninteractionsinautoimmunityandcancer |
| _version_ |
1807323779280404480 |