Memory consolidation and expression of object recognition are susceptible to retroactive interference
With the aim of analyzing if object recognition long-term memory (OR-LTM) formation is susceptible to retroactive interference (RI), we submitted rats to sequential sample sessions using the same arena but changing the identity of a pair of objects placed in it. Separate groups of animals were teste...
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todo:paper_10747427_v138_n_p198_Villar2023-10-03T16:03:02Z Memory consolidation and expression of object recognition are susceptible to retroactive interference Villar, M.E. Martinez, M.C. Lopes da Cunha, P. Ballarini, F. Viola, H. Dorsal hippocampus Long-term memory Medial prefrontal cortex Object recognition task Rat Retroactive interference animal experiment brain region dorsal hippocampus long term memory medial prefrontal cortex memory consolidation nonhuman recognition animal drug effects hippocampus long term memory male memory memory consolidation physiology prefrontal cortex rat recognition Wistar rat 4 aminobutyric acid A receptor stimulating agent muscimol Animals GABA-A Receptor Agonists Hippocampus Male Memory Memory Consolidation Memory, Long-Term Muscimol Prefrontal Cortex Rats Rats, Wistar Recognition (Psychology) With the aim of analyzing if object recognition long-term memory (OR-LTM) formation is susceptible to retroactive interference (RI), we submitted rats to sequential sample sessions using the same arena but changing the identity of a pair of objects placed in it. Separate groups of animals were tested in the arena in order to evaluate the LTM for these objects. Our results suggest that OR-LTM formation was retroactively interfered within a critical time window by the exploration of a new, but not familiar, object. This RI acted on the consolidation of the object explored in the first sample session because its OR-STM measured 3 h after training was not affected, whereas the OR-LTM measured at 24 h was impaired. This sample session also impaired the expression of OR memory when it took place before the test. Moreover, local inactivation of the dorsal Hippocampus (Hp) or the medial Prefrontal Cortex (mPFC) previous to the exploration of the second pair of objects impaired their consolidation restoring the LTM for the objects explored in the first session. This data suggests that both brain regions are involved in the processing of OR-memory and also that if those regions are engaged in another process before finishing the first consolidation process its LTM will be impaired by RI. © 2016 Elsevier Inc. Fil:Martinez, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Lopes da Cunha, P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Viola, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10747427_v138_n_p198_Villar |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Dorsal hippocampus Long-term memory Medial prefrontal cortex Object recognition task Rat Retroactive interference animal experiment brain region dorsal hippocampus long term memory medial prefrontal cortex memory consolidation nonhuman recognition animal drug effects hippocampus long term memory male memory memory consolidation physiology prefrontal cortex rat recognition Wistar rat 4 aminobutyric acid A receptor stimulating agent muscimol Animals GABA-A Receptor Agonists Hippocampus Male Memory Memory Consolidation Memory, Long-Term Muscimol Prefrontal Cortex Rats Rats, Wistar Recognition (Psychology) |
| spellingShingle |
Dorsal hippocampus Long-term memory Medial prefrontal cortex Object recognition task Rat Retroactive interference animal experiment brain region dorsal hippocampus long term memory medial prefrontal cortex memory consolidation nonhuman recognition animal drug effects hippocampus long term memory male memory memory consolidation physiology prefrontal cortex rat recognition Wistar rat 4 aminobutyric acid A receptor stimulating agent muscimol Animals GABA-A Receptor Agonists Hippocampus Male Memory Memory Consolidation Memory, Long-Term Muscimol Prefrontal Cortex Rats Rats, Wistar Recognition (Psychology) Villar, M.E. Martinez, M.C. Lopes da Cunha, P. Ballarini, F. Viola, H. Memory consolidation and expression of object recognition are susceptible to retroactive interference |
| topic_facet |
Dorsal hippocampus Long-term memory Medial prefrontal cortex Object recognition task Rat Retroactive interference animal experiment brain region dorsal hippocampus long term memory medial prefrontal cortex memory consolidation nonhuman recognition animal drug effects hippocampus long term memory male memory memory consolidation physiology prefrontal cortex rat recognition Wistar rat 4 aminobutyric acid A receptor stimulating agent muscimol Animals GABA-A Receptor Agonists Hippocampus Male Memory Memory Consolidation Memory, Long-Term Muscimol Prefrontal Cortex Rats Rats, Wistar Recognition (Psychology) |
| description |
With the aim of analyzing if object recognition long-term memory (OR-LTM) formation is susceptible to retroactive interference (RI), we submitted rats to sequential sample sessions using the same arena but changing the identity of a pair of objects placed in it. Separate groups of animals were tested in the arena in order to evaluate the LTM for these objects. Our results suggest that OR-LTM formation was retroactively interfered within a critical time window by the exploration of a new, but not familiar, object. This RI acted on the consolidation of the object explored in the first sample session because its OR-STM measured 3 h after training was not affected, whereas the OR-LTM measured at 24 h was impaired. This sample session also impaired the expression of OR memory when it took place before the test. Moreover, local inactivation of the dorsal Hippocampus (Hp) or the medial Prefrontal Cortex (mPFC) previous to the exploration of the second pair of objects impaired their consolidation restoring the LTM for the objects explored in the first session. This data suggests that both brain regions are involved in the processing of OR-memory and also that if those regions are engaged in another process before finishing the first consolidation process its LTM will be impaired by RI. © 2016 Elsevier Inc. |
| format |
JOUR |
| author |
Villar, M.E. Martinez, M.C. Lopes da Cunha, P. Ballarini, F. Viola, H. |
| author_facet |
Villar, M.E. Martinez, M.C. Lopes da Cunha, P. Ballarini, F. Viola, H. |
| author_sort |
Villar, M.E. |
| title |
Memory consolidation and expression of object recognition are susceptible to retroactive interference |
| title_short |
Memory consolidation and expression of object recognition are susceptible to retroactive interference |
| title_full |
Memory consolidation and expression of object recognition are susceptible to retroactive interference |
| title_fullStr |
Memory consolidation and expression of object recognition are susceptible to retroactive interference |
| title_full_unstemmed |
Memory consolidation and expression of object recognition are susceptible to retroactive interference |
| title_sort |
memory consolidation and expression of object recognition are susceptible to retroactive interference |
| url |
http://hdl.handle.net/20.500.12110/paper_10747427_v138_n_p198_Villar |
| work_keys_str_mv |
AT villarme memoryconsolidationandexpressionofobjectrecognitionaresusceptibletoretroactiveinterference AT martinezmc memoryconsolidationandexpressionofobjectrecognitionaresusceptibletoretroactiveinterference AT lopesdacunhap memoryconsolidationandexpressionofobjectrecognitionaresusceptibletoretroactiveinterference AT ballarinif memoryconsolidationandexpressionofobjectrecognitionaresusceptibletoretroactiveinterference AT violah memoryconsolidationandexpressionofobjectrecognitionaresusceptibletoretroactiveinterference |
| _version_ |
1782024890491076608 |