Reconsolidation-induced memory persistence: Participation of late phase hippocampal ERK activation

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Persistence is an attribute of long-term memories (LTM) that has recently caught researcher's attention in search for mechanisms triggered by experience that assure memory perdurability. Up-to-date, scarce evidence of relationship between reconsolidation and persistence has been described. Here...

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Autores principales:	Krawczyk, M.C., Navarro, N., Blake, M.G., Romano, A., Feld, M., Boccia, M.M.
Formato:	JOUR
Materias:	ERK/MAPK Inhibitory avoidance Memory persistence Memory reconsolidation Mice PD098059 2 (2 amino 3 methoxyphenyl)chromone mitogen activated protein kinase 1 mitogen activated protein kinase 3 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one flavonoid mitogen activated protein kinase protein kinase inhibitor animal behavior animal experiment animal tissue Article avoidance behavior controlled study enzyme activation enzyme activity enzyme inhibition footshock information retrieval long term memory male memory consolidation memory persistence mental function mental task mouse nonhuman task performance animal antagonists and inhibitors drug effects hippocampus metabolism physiology recall time factor Animals Avoidance Learning Extracellular Signal-Regulated MAP Kinases Flavonoids Hippocampus Memory Consolidation Memory, Long-Term Mental Recall Protein Kinase Inhibitors Time Factors
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_10747427_v133_n_p79_Krawczyk
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_10747427_v133_n_p79_Krawczyk
record_format	dspace
spelling	todo:paper_10747427_v133_n_p79_Krawczyk2023-10-03T16:03:01Z Reconsolidation-induced memory persistence: Participation of late phase hippocampal ERK activation Krawczyk, M.C. Navarro, N. Blake, M.G. Romano, A. Feld, M. Boccia, M.M. ERK/MAPK Inhibitory avoidance Memory persistence Memory reconsolidation Mice PD098059 2 (2 amino 3 methoxyphenyl)chromone mitogen activated protein kinase 1 mitogen activated protein kinase 3 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one flavonoid mitogen activated protein kinase protein kinase inhibitor animal behavior animal experiment animal tissue Article avoidance behavior controlled study enzyme activation enzyme activity enzyme inhibition footshock information retrieval long term memory male memory consolidation memory persistence mental function mental task mouse nonhuman task performance animal antagonists and inhibitors drug effects hippocampus long term memory memory consolidation metabolism physiology recall time factor Animals Avoidance Learning Extracellular Signal-Regulated MAP Kinases Flavonoids Hippocampus Memory Consolidation Memory, Long-Term Mental Recall Mice Protein Kinase Inhibitors Time Factors Persistence is an attribute of long-term memories (LTM) that has recently caught researcher's attention in search for mechanisms triggered by experience that assure memory perdurability. Up-to-date, scarce evidence of relationship between reconsolidation and persistence has been described. Here, we characterized hippocampal ERK participation in LTM reconsolidation and persistence using an inhibitory avoidance task (IA) at different time points. Intra-dorsal-hippocampal (dHIP) administration of an ERK inhibitor (PD098059, PD, 1.0 μg/hippocampus) 3 h after retrieval did not affect reconsolidation of a strong IA, when tested 24 h apart. However, the same manipulation impaired performance when animals were tested at 7 d, regardless of the training's strength; and being specific to memory reactivation. To the best of our knowledge, this is the first report showing that persistence might be triggered after memory reactivation involving an ERK/MAPK-dependent process. © 2016 Elsevier Inc. Fil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Feld, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10747427_v133_n_p79_Krawczyk
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	ERK/MAPK Inhibitory avoidance Memory persistence Memory reconsolidation Mice PD098059 2 (2 amino 3 methoxyphenyl)chromone mitogen activated protein kinase 1 mitogen activated protein kinase 3 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one flavonoid mitogen activated protein kinase protein kinase inhibitor animal behavior animal experiment animal tissue Article avoidance behavior controlled study enzyme activation enzyme activity enzyme inhibition footshock information retrieval long term memory male memory consolidation memory persistence mental function mental task mouse nonhuman task performance animal antagonists and inhibitors drug effects hippocampus long term memory memory consolidation metabolism physiology recall time factor Animals Avoidance Learning Extracellular Signal-Regulated MAP Kinases Flavonoids Hippocampus Memory Consolidation Memory, Long-Term Mental Recall Mice Protein Kinase Inhibitors Time Factors
spellingShingle	ERK/MAPK Inhibitory avoidance Memory persistence Memory reconsolidation Mice PD098059 2 (2 amino 3 methoxyphenyl)chromone mitogen activated protein kinase 1 mitogen activated protein kinase 3 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one flavonoid mitogen activated protein kinase protein kinase inhibitor animal behavior animal experiment animal tissue Article avoidance behavior controlled study enzyme activation enzyme activity enzyme inhibition footshock information retrieval long term memory male memory consolidation memory persistence mental function mental task mouse nonhuman task performance animal antagonists and inhibitors drug effects hippocampus long term memory memory consolidation metabolism physiology recall time factor Animals Avoidance Learning Extracellular Signal-Regulated MAP Kinases Flavonoids Hippocampus Memory Consolidation Memory, Long-Term Mental Recall Mice Protein Kinase Inhibitors Time Factors Krawczyk, M.C. Navarro, N. Blake, M.G. Romano, A. Feld, M. Boccia, M.M. Reconsolidation-induced memory persistence: Participation of late phase hippocampal ERK activation
topic_facet	ERK/MAPK Inhibitory avoidance Memory persistence Memory reconsolidation Mice PD098059 2 (2 amino 3 methoxyphenyl)chromone mitogen activated protein kinase 1 mitogen activated protein kinase 3 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one flavonoid mitogen activated protein kinase protein kinase inhibitor animal behavior animal experiment animal tissue Article avoidance behavior controlled study enzyme activation enzyme activity enzyme inhibition footshock information retrieval long term memory male memory consolidation memory persistence mental function mental task mouse nonhuman task performance animal antagonists and inhibitors drug effects hippocampus long term memory memory consolidation metabolism physiology recall time factor Animals Avoidance Learning Extracellular Signal-Regulated MAP Kinases Flavonoids Hippocampus Memory Consolidation Memory, Long-Term Mental Recall Mice Protein Kinase Inhibitors Time Factors
description	Persistence is an attribute of long-term memories (LTM) that has recently caught researcher's attention in search for mechanisms triggered by experience that assure memory perdurability. Up-to-date, scarce evidence of relationship between reconsolidation and persistence has been described. Here, we characterized hippocampal ERK participation in LTM reconsolidation and persistence using an inhibitory avoidance task (IA) at different time points. Intra-dorsal-hippocampal (dHIP) administration of an ERK inhibitor (PD098059, PD, 1.0 μg/hippocampus) 3 h after retrieval did not affect reconsolidation of a strong IA, when tested 24 h apart. However, the same manipulation impaired performance when animals were tested at 7 d, regardless of the training's strength; and being specific to memory reactivation. To the best of our knowledge, this is the first report showing that persistence might be triggered after memory reactivation involving an ERK/MAPK-dependent process. © 2016 Elsevier Inc.
format	JOUR
author	Krawczyk, M.C. Navarro, N. Blake, M.G. Romano, A. Feld, M. Boccia, M.M.
author_facet	Krawczyk, M.C. Navarro, N. Blake, M.G. Romano, A. Feld, M. Boccia, M.M.
author_sort	Krawczyk, M.C.
title	Reconsolidation-induced memory persistence: Participation of late phase hippocampal ERK activation
title_short	Reconsolidation-induced memory persistence: Participation of late phase hippocampal ERK activation
title_full	Reconsolidation-induced memory persistence: Participation of late phase hippocampal ERK activation
title_fullStr	Reconsolidation-induced memory persistence: Participation of late phase hippocampal ERK activation
title_full_unstemmed	Reconsolidation-induced memory persistence: Participation of late phase hippocampal ERK activation
title_sort	reconsolidation-induced memory persistence: participation of late phase hippocampal erk activation
url	http://hdl.handle.net/20.500.12110/paper_10747427_v133_n_p79_Krawczyk
work_keys_str_mv	AT krawczykmc reconsolidationinducedmemorypersistenceparticipationoflatephasehippocampalerkactivation AT navarron reconsolidationinducedmemorypersistenceparticipationoflatephasehippocampalerkactivation AT blakemg reconsolidationinducedmemorypersistenceparticipationoflatephasehippocampalerkactivation AT romanoa reconsolidationinducedmemorypersistenceparticipationoflatephasehippocampalerkactivation AT feldm reconsolidationinducedmemorypersistenceparticipationoflatephasehippocampalerkactivation AT bocciamm reconsolidationinducedmemorypersistenceparticipationoflatephasehippocampalerkactivation
_version_	1807314847562465280

Reconsolidation-induced memory persistence: Participation of late phase hippocampal ERK activation

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