Identifying restriction factors for hemorrhagic fever viruses: Dengue and junín
Host restriction factors are cellular components that interfere with viral multiplication. They are up-regulated and expressed upon viral infection and in consequence their activity is specific. So far several important restriction factors have been described against diverse viruses. The cellular an...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_10643745_v1604_n_p351_Giovannoni |
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todo:paper_10643745_v1604_n_p351_Giovannoni2023-10-03T16:01:56Z Identifying restriction factors for hemorrhagic fever viruses: Dengue and junín Giovannoni, F. Cárcamo, J.R.P. Morell, M.L. Cordo, S.M. García, C.C. Antiviral proteins Dengue Junín Lipid droplets Microscopy SiRNA Viral restriction antiviral activity cellular distribution Dengue virus gene overexpression hemorrhagic fever Junin virus nonhuman virus gene virus infectivity virus morphogenesis virus replication animal dengue Dengue virus hemorrhagic fever with renal syndrome human Junin virus metabolism virology small interfering RNA Animals Dengue Dengue Virus Hemorrhagic Fever with Renal Syndrome Humans Junin virus RNA, Small Interfering Host restriction factors are cellular components that interfere with viral multiplication. They are up-regulated and expressed upon viral infection and in consequence their activity is specific. So far several important restriction factors have been described against diverse viruses. The cellular antiviral mechanisms defined include proteins with the ability to interfere with early steps of viral replication and others that have been shown to block viral morphogenesis. However, other strategies by which the antiviral action is exerted still remain elusive. An additional interesting matter is how viruses also developed ways to by-pass these host-specific obstacles. Thus, unusual cell localization or re-localization represents a frequent virus choice to evade the cellular surveillance. In the present chapter, we summarize methods to identify cell restriction factors, their antiviral activity, and possible subcellular locations where their activity can take place. © Springer Science+Business Media LLC 2018. SER info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10643745_v1604_n_p351_Giovannoni |
| institution |
Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Antiviral proteins Dengue Junín Lipid droplets Microscopy SiRNA Viral restriction antiviral activity cellular distribution Dengue virus gene overexpression hemorrhagic fever Junin virus nonhuman virus gene virus infectivity virus morphogenesis virus replication animal dengue Dengue virus hemorrhagic fever with renal syndrome human Junin virus metabolism virology small interfering RNA Animals Dengue Dengue Virus Hemorrhagic Fever with Renal Syndrome Humans Junin virus RNA, Small Interfering |
| spellingShingle |
Antiviral proteins Dengue Junín Lipid droplets Microscopy SiRNA Viral restriction antiviral activity cellular distribution Dengue virus gene overexpression hemorrhagic fever Junin virus nonhuman virus gene virus infectivity virus morphogenesis virus replication animal dengue Dengue virus hemorrhagic fever with renal syndrome human Junin virus metabolism virology small interfering RNA Animals Dengue Dengue Virus Hemorrhagic Fever with Renal Syndrome Humans Junin virus RNA, Small Interfering Giovannoni, F. Cárcamo, J.R.P. Morell, M.L. Cordo, S.M. García, C.C. Identifying restriction factors for hemorrhagic fever viruses: Dengue and junín |
| topic_facet |
Antiviral proteins Dengue Junín Lipid droplets Microscopy SiRNA Viral restriction antiviral activity cellular distribution Dengue virus gene overexpression hemorrhagic fever Junin virus nonhuman virus gene virus infectivity virus morphogenesis virus replication animal dengue Dengue virus hemorrhagic fever with renal syndrome human Junin virus metabolism virology small interfering RNA Animals Dengue Dengue Virus Hemorrhagic Fever with Renal Syndrome Humans Junin virus RNA, Small Interfering |
| description |
Host restriction factors are cellular components that interfere with viral multiplication. They are up-regulated and expressed upon viral infection and in consequence their activity is specific. So far several important restriction factors have been described against diverse viruses. The cellular antiviral mechanisms defined include proteins with the ability to interfere with early steps of viral replication and others that have been shown to block viral morphogenesis. However, other strategies by which the antiviral action is exerted still remain elusive. An additional interesting matter is how viruses also developed ways to by-pass these host-specific obstacles. Thus, unusual cell localization or re-localization represents a frequent virus choice to evade the cellular surveillance. In the present chapter, we summarize methods to identify cell restriction factors, their antiviral activity, and possible subcellular locations where their activity can take place. © Springer Science+Business Media LLC 2018. |
| format |
SER |
| author |
Giovannoni, F. Cárcamo, J.R.P. Morell, M.L. Cordo, S.M. García, C.C. |
| author_facet |
Giovannoni, F. Cárcamo, J.R.P. Morell, M.L. Cordo, S.M. García, C.C. |
| author_sort |
Giovannoni, F. |
| title |
Identifying restriction factors for hemorrhagic fever viruses: Dengue and junín |
| title_short |
Identifying restriction factors for hemorrhagic fever viruses: Dengue and junín |
| title_full |
Identifying restriction factors for hemorrhagic fever viruses: Dengue and junín |
| title_fullStr |
Identifying restriction factors for hemorrhagic fever viruses: Dengue and junín |
| title_full_unstemmed |
Identifying restriction factors for hemorrhagic fever viruses: Dengue and junín |
| title_sort |
identifying restriction factors for hemorrhagic fever viruses: dengue and junín |
| url |
http://hdl.handle.net/20.500.12110/paper_10643745_v1604_n_p351_Giovannoni |
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