Administration of the anesthetic isoflurane to mice: A model for acute intermittent porphyria?
The effects of isoflurane, a commonly used volatile anesthetic, on the activity of some haem enzymes in liver, kidney, and blood, and glucose content in liver and blood were studied. Mice were injected with different doses of the drug (0.5-6 mL/kg) and killed at varying intervals after injection (5-...
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todo:paper_10568719_v28_n4_p191_Buzaleh2023-10-03T16:00:54Z Administration of the anesthetic isoflurane to mice: A model for acute intermittent porphyria? Buzaleh, A.M. de Salamanca, R.E. Del Carmen Batlle, A.M. Acute Intermittent Porphyria Anesthesia Isoflurane 5 aminolevulinate synthase glucose heme oxygenase inhalation anesthetic agent isoflurane porphobilinogen deaminase porphobilinogenase unclassified drug acute intermittent porphyria anesthesia animal experiment animal model animal tissue article blood controlled study dose time effect relation enzyme activity glucose metabolism heme synthesis intraperitoneal drug administration kidney liver mouse nonhuman priority journal Animal Disease Models, Animal Dose-Response Relationship, Drug Enzyme Activation Glucose Isoflurane Kidney Liver Mice Porphyria, Acute Intermittent Support, Non-U.S. Gov't The effects of isoflurane, a commonly used volatile anesthetic, on the activity of some haem enzymes in liver, kidney, and blood, and glucose content in liver and blood were studied. Mice were injected with different doses of the drug (0.5-6 mL/kg) and killed at varying intervals after injection (5-240 min). Within this dose range, optimal effects on alteration of haem metabolism were obtained at 2 mL/kg. The time-response profile for each enzyme was different. Blood porphobilinogenase (PBGase) and deaminase showed lower activities 20 min after anesthesia. This diminution coupled with the induction of δ-aminolevulinate synthetase activity observed soon after anesthesia (5 min) would fit well with the expected biochemical changes occurring in acute intermittent porphyria, indicating that this may be a suitable animal model for this disease. © 1992. Fil:Buzaleh, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Del Carmen Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10568719_v28_n4_p191_Buzaleh |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Acute Intermittent Porphyria Anesthesia Isoflurane 5 aminolevulinate synthase glucose heme oxygenase inhalation anesthetic agent isoflurane porphobilinogen deaminase porphobilinogenase unclassified drug acute intermittent porphyria anesthesia animal experiment animal model animal tissue article blood controlled study dose time effect relation enzyme activity glucose metabolism heme synthesis intraperitoneal drug administration kidney liver mouse nonhuman priority journal Animal Disease Models, Animal Dose-Response Relationship, Drug Enzyme Activation Glucose Isoflurane Kidney Liver Mice Porphyria, Acute Intermittent Support, Non-U.S. Gov't |
| spellingShingle |
Acute Intermittent Porphyria Anesthesia Isoflurane 5 aminolevulinate synthase glucose heme oxygenase inhalation anesthetic agent isoflurane porphobilinogen deaminase porphobilinogenase unclassified drug acute intermittent porphyria anesthesia animal experiment animal model animal tissue article blood controlled study dose time effect relation enzyme activity glucose metabolism heme synthesis intraperitoneal drug administration kidney liver mouse nonhuman priority journal Animal Disease Models, Animal Dose-Response Relationship, Drug Enzyme Activation Glucose Isoflurane Kidney Liver Mice Porphyria, Acute Intermittent Support, Non-U.S. Gov't Buzaleh, A.M. de Salamanca, R.E. Del Carmen Batlle, A.M. Administration of the anesthetic isoflurane to mice: A model for acute intermittent porphyria? |
| topic_facet |
Acute Intermittent Porphyria Anesthesia Isoflurane 5 aminolevulinate synthase glucose heme oxygenase inhalation anesthetic agent isoflurane porphobilinogen deaminase porphobilinogenase unclassified drug acute intermittent porphyria anesthesia animal experiment animal model animal tissue article blood controlled study dose time effect relation enzyme activity glucose metabolism heme synthesis intraperitoneal drug administration kidney liver mouse nonhuman priority journal Animal Disease Models, Animal Dose-Response Relationship, Drug Enzyme Activation Glucose Isoflurane Kidney Liver Mice Porphyria, Acute Intermittent Support, Non-U.S. Gov't |
| description |
The effects of isoflurane, a commonly used volatile anesthetic, on the activity of some haem enzymes in liver, kidney, and blood, and glucose content in liver and blood were studied. Mice were injected with different doses of the drug (0.5-6 mL/kg) and killed at varying intervals after injection (5-240 min). Within this dose range, optimal effects on alteration of haem metabolism were obtained at 2 mL/kg. The time-response profile for each enzyme was different. Blood porphobilinogenase (PBGase) and deaminase showed lower activities 20 min after anesthesia. This diminution coupled with the induction of δ-aminolevulinate synthetase activity observed soon after anesthesia (5 min) would fit well with the expected biochemical changes occurring in acute intermittent porphyria, indicating that this may be a suitable animal model for this disease. © 1992. |
| format |
JOUR |
| author |
Buzaleh, A.M. de Salamanca, R.E. Del Carmen Batlle, A.M. |
| author_facet |
Buzaleh, A.M. de Salamanca, R.E. Del Carmen Batlle, A.M. |
| author_sort |
Buzaleh, A.M. |
| title |
Administration of the anesthetic isoflurane to mice: A model for acute intermittent porphyria? |
| title_short |
Administration of the anesthetic isoflurane to mice: A model for acute intermittent porphyria? |
| title_full |
Administration of the anesthetic isoflurane to mice: A model for acute intermittent porphyria? |
| title_fullStr |
Administration of the anesthetic isoflurane to mice: A model for acute intermittent porphyria? |
| title_full_unstemmed |
Administration of the anesthetic isoflurane to mice: A model for acute intermittent porphyria? |
| title_sort |
administration of the anesthetic isoflurane to mice: a model for acute intermittent porphyria? |
| url |
http://hdl.handle.net/20.500.12110/paper_10568719_v28_n4_p191_Buzaleh |
| work_keys_str_mv |
AT buzaleham administrationoftheanestheticisofluranetomiceamodelforacuteintermittentporphyria AT desalamancare administrationoftheanestheticisofluranetomiceamodelforacuteintermittentporphyria AT delcarmenbatlleam administrationoftheanestheticisofluranetomiceamodelforacuteintermittentporphyria |
| _version_ |
1807318127936012288 |