Administration of volatile anaesthetics to animals treated with cobalt as inductor of heme oxygenase
The effect of anaesthesia with Enflurane or Isoflurane (a single dose of 1 ml/kg, i.p.) administered to animals treated 24 hours before with cobaltous chloride (a single dose of 125 μmol/kg, i.p.), a known inductor of Heme-ox, was investigated. The expected induction of Heme-ox (285%) produced by Co...
Guardado en:
| Autores principales: | , |
|---|---|
| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_10288945_v11_n1_p39_Buzaleh |
| Aporte de: |
| id |
todo:paper_10288945_v11_n1_p39_Buzaleh |
|---|---|
| record_format |
dspace |
| spelling |
todo:paper_10288945_v11_n1_p39_Buzaleh2023-10-03T15:57:03Z Administration of volatile anaesthetics to animals treated with cobalt as inductor of heme oxygenase Buzaleh, A.M. Del Carmen Batlle, A.M. Cobalt Drug metabolizing enzyme system Enflurane Heme metabolism Heme oxygenase Isoflurane cobalt chloride enflurane enzyme inducing agent heme heme oxygenase inhalation anesthetic agent isoflurane porphobilinogen deaminase acute intermittent porphyria anesthesia animal experiment animal model article biochemistry controlled study drug mechanism drug metabolism enzyme activity enzyme blood level enzyme induction male mouse nonhuman priority journal regulatory mechanism The effect of anaesthesia with Enflurane or Isoflurane (a single dose of 1 ml/kg, i.p.) administered to animals treated 24 hours before with cobaltous chloride (a single dose of 125 μmol/kg, i.p.), a known inductor of Heme-ox, was investigated. The expected induction of Heme-ox (285%) produced by Co administration was abolished by anaesthesia. A 45% reduction of blood Porphobilinogenase and Deaminase activities was found after treatment with Co and Isoflurane, reproducing in these animals the biochemical signs of acute porphyria. The regulation of heme pathway and the involvement of the metabolizing drug enzyme system was also studied. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10288945_v11_n1_p39_Buzaleh |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Cobalt Drug metabolizing enzyme system Enflurane Heme metabolism Heme oxygenase Isoflurane cobalt chloride enflurane enzyme inducing agent heme heme oxygenase inhalation anesthetic agent isoflurane porphobilinogen deaminase acute intermittent porphyria anesthesia animal experiment animal model article biochemistry controlled study drug mechanism drug metabolism enzyme activity enzyme blood level enzyme induction male mouse nonhuman priority journal regulatory mechanism |
| spellingShingle |
Cobalt Drug metabolizing enzyme system Enflurane Heme metabolism Heme oxygenase Isoflurane cobalt chloride enflurane enzyme inducing agent heme heme oxygenase inhalation anesthetic agent isoflurane porphobilinogen deaminase acute intermittent porphyria anesthesia animal experiment animal model article biochemistry controlled study drug mechanism drug metabolism enzyme activity enzyme blood level enzyme induction male mouse nonhuman priority journal regulatory mechanism Buzaleh, A.M. Del Carmen Batlle, A.M. Administration of volatile anaesthetics to animals treated with cobalt as inductor of heme oxygenase |
| topic_facet |
Cobalt Drug metabolizing enzyme system Enflurane Heme metabolism Heme oxygenase Isoflurane cobalt chloride enflurane enzyme inducing agent heme heme oxygenase inhalation anesthetic agent isoflurane porphobilinogen deaminase acute intermittent porphyria anesthesia animal experiment animal model article biochemistry controlled study drug mechanism drug metabolism enzyme activity enzyme blood level enzyme induction male mouse nonhuman priority journal regulatory mechanism |
| description |
The effect of anaesthesia with Enflurane or Isoflurane (a single dose of 1 ml/kg, i.p.) administered to animals treated 24 hours before with cobaltous chloride (a single dose of 125 μmol/kg, i.p.), a known inductor of Heme-ox, was investigated. The expected induction of Heme-ox (285%) produced by Co administration was abolished by anaesthesia. A 45% reduction of blood Porphobilinogenase and Deaminase activities was found after treatment with Co and Isoflurane, reproducing in these animals the biochemical signs of acute porphyria. The regulation of heme pathway and the involvement of the metabolizing drug enzyme system was also studied. |
| format |
JOUR |
| author |
Buzaleh, A.M. Del Carmen Batlle, A.M. |
| author_facet |
Buzaleh, A.M. Del Carmen Batlle, A.M. |
| author_sort |
Buzaleh, A.M. |
| title |
Administration of volatile anaesthetics to animals treated with cobalt as inductor of heme oxygenase |
| title_short |
Administration of volatile anaesthetics to animals treated with cobalt as inductor of heme oxygenase |
| title_full |
Administration of volatile anaesthetics to animals treated with cobalt as inductor of heme oxygenase |
| title_fullStr |
Administration of volatile anaesthetics to animals treated with cobalt as inductor of heme oxygenase |
| title_full_unstemmed |
Administration of volatile anaesthetics to animals treated with cobalt as inductor of heme oxygenase |
| title_sort |
administration of volatile anaesthetics to animals treated with cobalt as inductor of heme oxygenase |
| url |
http://hdl.handle.net/20.500.12110/paper_10288945_v11_n1_p39_Buzaleh |
| work_keys_str_mv |
AT buzaleham administrationofvolatileanaestheticstoanimalstreatedwithcobaltasinductorofhemeoxygenase AT delcarmenbatlleam administrationofvolatileanaestheticstoanimalstreatedwithcobaltasinductorofhemeoxygenase |
| _version_ |
1807321111976738816 |