Lipase-catalyzed preparation of biologically active esters of dehydroepiandrosterone

A series of acyl esters derivatives of dehydroepiandrosterone have been prepared by an enzymatic methodology. The acyl chain had a length that varied from two to eighteen carbon atoms. The C18 derivative could be saturated or unsaturated. Following this biocatalytic approach we have also obtained a...

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Detalles Bibliográficos
Autores principales: Bruttomesso, A.C., Tiscornia, A., Baldessari, A.
Formato: JOUR
Materias:
Dehydroepiandrosterone
Enzymatic acylation
Lipase-catalyzed
Biocatalysts
Carbon
Catalysis
Environmental impact
Esterification
Acyl derivatives
Transesterification reactions
Esters
3beta (3 chloropropoxy) 5 androsten 17 one
3beta 9 octadecanoyloxy 5 androsten 17 one
3beta 9,12 octadecadienoyloxy 5 androsten 17 one
3beta 9,12,15 octadecatrienoyloxy 5 androsten 17 one
3beta acetoxy 5 androsten 17 one
3beta butyroxy 5 androsten 17 one
3beta dodecanoyloxy 5 androsten 17 one
3beta hexadecanoyloxy 5 androsten 17 one
3beta hexanoyloxy 5 androsten 17 one
3beta octadecanoyloxy 5 androsten 17 one
3beta propoxy 5 androsten 17 one
carboxylic acid derivative
ester derivative
prasterone
steroid
triacylglycerol lipase
unclassified drug
acylation
analytic method
article
biocatalyst
chemical reaction kinetics
controlled study
drug activity
drug structure
drug synthesis
economic aspect
environmental impact
esterification
quantum yield
structure analysis
transesterification
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_10242422_v22_n3_p215_Bruttomesso
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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