Decrease in salivary secretion by radiation mediated by nitric oxide and prostaglandins
Objective: In the present work, we evaluated the effect of exposing the submandibular glands (SMG) to radiation, studying different functional parameters such as salivary secretion, nitric oxide (NO) production, reactive oxygen species formation, prostaglandin (PGE) content and apoptosis. Methods: W...
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todo:paper_10217401_v13_n1_p19_DeLaCal2023-10-03T15:56:36Z Decrease in salivary secretion by radiation mediated by nitric oxide and prostaglandins De La Cal, C. Lomniczi, A. Mohn, C.E. De Laurentiis, A. Casal, M. Chiarenza, A. Paz, D. McCann, S.M. Rettori, V. Elverdín, J.C. Apoptosis Nitric oxide synthase Submandibular glands Xerostomia inducible nitric oxide synthase nitric oxide nitric oxide synthase noradrenalin prostaglandin reactive oxygen metabolite animal experiment animal tissue apoptosis article controlled study enzyme activity female femoral vein gamma radiation irradiation lipid peroxidation mitochondrion nonhuman priority journal protein expression radiation rat salivation submandibular gland tissue injury Animals Apoptosis Disease Models, Animal Down-Regulation Epithelial Cells Female Head and Neck Neoplasms Lipid Peroxidation Nitric Oxide Nitric Oxide Synthase Type II Oxidative Stress Prostaglandins Radiotherapy Rats Saliva Submandibular Gland Xerostomia Objective: In the present work, we evaluated the effect of exposing the submandibular glands (SMG) to radiation, studying different functional parameters such as salivary secretion, nitric oxide (NO) production, reactive oxygen species formation, prostaglandin (PGE) content and apoptosis. Methods: We irradiated rats in the head and neck region with a single dose of γ-ray radiation of 15 Gy. Two hours after radiation, we measured norepinephrine- induced salivary secretion. After that, the SMG were dissected, and in this tissue, we measured the activity of NO synthase (NOS), the PGE content, the amount of reactive oxygen species, apoptotic cells and mitochondrial inducible NOS (iNOS) expression. Results: We found that radiation decreased salivary secretion when 10 and 30 μg/kg of norepinephrine was administered via the right femoral vein. We observed that iNOS activity was reduced and PGE content increased after radiation in SMG, indicating that NO and PGEs may participate in salivary secretion. The expression of mitochondrial NOS was increased after radiation leading to the formation of large amounts of NO that acts as a proapoptotic signal. In fact, we observed an augmentation in apoptotic cells. In this study, we also observed an increase in lipid peroxidation induced by radiation that may contribute to tissue damage. Conclusions: Our results indicate that radiation induced a decrease in salivary secretion and SMG iNOS activity, meanwhile the PGE content, the lipid peroxidation and apoptosis increased in the tissue. These modifications decrease salivary secretion. Copyright © 2006 S. Karger AG. Fil:Lomniczi, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Paz, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10217401_v13_n1_p19_DeLaCal |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
Apoptosis Nitric oxide synthase Submandibular glands Xerostomia inducible nitric oxide synthase nitric oxide nitric oxide synthase noradrenalin prostaglandin reactive oxygen metabolite animal experiment animal tissue apoptosis article controlled study enzyme activity female femoral vein gamma radiation irradiation lipid peroxidation mitochondrion nonhuman priority journal protein expression radiation rat salivation submandibular gland tissue injury Animals Apoptosis Disease Models, Animal Down-Regulation Epithelial Cells Female Head and Neck Neoplasms Lipid Peroxidation Nitric Oxide Nitric Oxide Synthase Type II Oxidative Stress Prostaglandins Radiotherapy Rats Saliva Submandibular Gland Xerostomia |
spellingShingle |
Apoptosis Nitric oxide synthase Submandibular glands Xerostomia inducible nitric oxide synthase nitric oxide nitric oxide synthase noradrenalin prostaglandin reactive oxygen metabolite animal experiment animal tissue apoptosis article controlled study enzyme activity female femoral vein gamma radiation irradiation lipid peroxidation mitochondrion nonhuman priority journal protein expression radiation rat salivation submandibular gland tissue injury Animals Apoptosis Disease Models, Animal Down-Regulation Epithelial Cells Female Head and Neck Neoplasms Lipid Peroxidation Nitric Oxide Nitric Oxide Synthase Type II Oxidative Stress Prostaglandins Radiotherapy Rats Saliva Submandibular Gland Xerostomia De La Cal, C. Lomniczi, A. Mohn, C.E. De Laurentiis, A. Casal, M. Chiarenza, A. Paz, D. McCann, S.M. Rettori, V. Elverdín, J.C. Decrease in salivary secretion by radiation mediated by nitric oxide and prostaglandins |
topic_facet |
Apoptosis Nitric oxide synthase Submandibular glands Xerostomia inducible nitric oxide synthase nitric oxide nitric oxide synthase noradrenalin prostaglandin reactive oxygen metabolite animal experiment animal tissue apoptosis article controlled study enzyme activity female femoral vein gamma radiation irradiation lipid peroxidation mitochondrion nonhuman priority journal protein expression radiation rat salivation submandibular gland tissue injury Animals Apoptosis Disease Models, Animal Down-Regulation Epithelial Cells Female Head and Neck Neoplasms Lipid Peroxidation Nitric Oxide Nitric Oxide Synthase Type II Oxidative Stress Prostaglandins Radiotherapy Rats Saliva Submandibular Gland Xerostomia |
description |
Objective: In the present work, we evaluated the effect of exposing the submandibular glands (SMG) to radiation, studying different functional parameters such as salivary secretion, nitric oxide (NO) production, reactive oxygen species formation, prostaglandin (PGE) content and apoptosis. Methods: We irradiated rats in the head and neck region with a single dose of γ-ray radiation of 15 Gy. Two hours after radiation, we measured norepinephrine- induced salivary secretion. After that, the SMG were dissected, and in this tissue, we measured the activity of NO synthase (NOS), the PGE content, the amount of reactive oxygen species, apoptotic cells and mitochondrial inducible NOS (iNOS) expression. Results: We found that radiation decreased salivary secretion when 10 and 30 μg/kg of norepinephrine was administered via the right femoral vein. We observed that iNOS activity was reduced and PGE content increased after radiation in SMG, indicating that NO and PGEs may participate in salivary secretion. The expression of mitochondrial NOS was increased after radiation leading to the formation of large amounts of NO that acts as a proapoptotic signal. In fact, we observed an augmentation in apoptotic cells. In this study, we also observed an increase in lipid peroxidation induced by radiation that may contribute to tissue damage. Conclusions: Our results indicate that radiation induced a decrease in salivary secretion and SMG iNOS activity, meanwhile the PGE content, the lipid peroxidation and apoptosis increased in the tissue. These modifications decrease salivary secretion. Copyright © 2006 S. Karger AG. |
format |
JOUR |
author |
De La Cal, C. Lomniczi, A. Mohn, C.E. De Laurentiis, A. Casal, M. Chiarenza, A. Paz, D. McCann, S.M. Rettori, V. Elverdín, J.C. |
author_facet |
De La Cal, C. Lomniczi, A. Mohn, C.E. De Laurentiis, A. Casal, M. Chiarenza, A. Paz, D. McCann, S.M. Rettori, V. Elverdín, J.C. |
author_sort |
De La Cal, C. |
title |
Decrease in salivary secretion by radiation mediated by nitric oxide and prostaglandins |
title_short |
Decrease in salivary secretion by radiation mediated by nitric oxide and prostaglandins |
title_full |
Decrease in salivary secretion by radiation mediated by nitric oxide and prostaglandins |
title_fullStr |
Decrease in salivary secretion by radiation mediated by nitric oxide and prostaglandins |
title_full_unstemmed |
Decrease in salivary secretion by radiation mediated by nitric oxide and prostaglandins |
title_sort |
decrease in salivary secretion by radiation mediated by nitric oxide and prostaglandins |
url |
http://hdl.handle.net/20.500.12110/paper_10217401_v13_n1_p19_DeLaCal |
work_keys_str_mv |
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1782028293164236800 |