An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes

The lipophilic tetrasubstituted sensitizer 2,9(10),16(17),23(24)-tetrakis- (1-adamantylsulfanyl)phthalocyaninatozinc(II) (ZnPc) was incorporated into different liposomal formulations in order to evaluate its photophysical properties, as well as the size, incorporation efficiency, thermotropic proper...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: López Zeballos, N.C., García Vior, M.C., Awruch, J., Dicelio, L.E.
Formato: JOUR
Materias:
Carriers
Liposomes
Phthalocyanines
Singlet oxygen
Stability
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_10106030_v235_n_p7_LopezZeballos
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_10106030_v235_n_p7_LopezZeballos
record_format dspace
spelling todo:paper_10106030_v235_n_p7_LopezZeballos2023-10-03T15:56:01Z An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes López Zeballos, N.C. García Vior, M.C. Awruch, J. Dicelio, L.E. Carriers Liposomes Phthalocyanines Singlet oxygen Stability The lipophilic tetrasubstituted sensitizer 2,9(10),16(17),23(24)-tetrakis- (1-adamantylsulfanyl)phthalocyaninatozinc(II) (ZnPc) was incorporated into different liposomal formulations in order to evaluate its photophysical properties, as well as the size, incorporation efficiency, thermotropic properties and stability of liposomes during a time period. Liposomes were prepared by the thin-layer evaporation technique followed by hydratation with buffer at pH 7.4 and 0.15 M NaCl. Small unilamellar vesicles (SUV) were obtained after sonicating the mixture. Phthalocyanine was incorporated efficiently into all the liposomal formulations. The shape of ZnPc spectra depended on the environment. The S-PEG liposomal formulation showed the lowest aggregation value. The average diameter of liposomes with different lipid compositions varied from 49.70 ± 0.09 to 223.10 ± 0.36 nm, with significant differences between the various liposomal preparations. The inclusion of cholesterol (CHOL) and polyethylene glycol (PEG) on the lipid bilayer did not influence the size of the particles. The formulations with PEG increased the stability of liposomes for at least 9 months. After a long storage, the most stable formulations were those without CHOL. Singlet molecular oxygen values ranged between 0.10 and 0.26. These values were higher than other zinc(II) phthalocyanines incorporated into dimyristoyl phosphatidylcholine (DMPC) liposomes or Tween 80. © 2012 Elsevier B.V. Fil:Dicelio, L.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10106030_v235_n_p7_LopezZeballos
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Carriers
Liposomes
Phthalocyanines
Singlet oxygen
Stability
spellingShingle Carriers
Liposomes
Phthalocyanines
Singlet oxygen
Stability
López Zeballos, N.C.
García Vior, M.C.
Awruch, J.
Dicelio, L.E.
An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes
topic_facet Carriers
Liposomes
Phthalocyanines
Singlet oxygen
Stability
description The lipophilic tetrasubstituted sensitizer 2,9(10),16(17),23(24)-tetrakis- (1-adamantylsulfanyl)phthalocyaninatozinc(II) (ZnPc) was incorporated into different liposomal formulations in order to evaluate its photophysical properties, as well as the size, incorporation efficiency, thermotropic properties and stability of liposomes during a time period. Liposomes were prepared by the thin-layer evaporation technique followed by hydratation with buffer at pH 7.4 and 0.15 M NaCl. Small unilamellar vesicles (SUV) were obtained after sonicating the mixture. Phthalocyanine was incorporated efficiently into all the liposomal formulations. The shape of ZnPc spectra depended on the environment. The S-PEG liposomal formulation showed the lowest aggregation value. The average diameter of liposomes with different lipid compositions varied from 49.70 ± 0.09 to 223.10 ± 0.36 nm, with significant differences between the various liposomal preparations. The inclusion of cholesterol (CHOL) and polyethylene glycol (PEG) on the lipid bilayer did not influence the size of the particles. The formulations with PEG increased the stability of liposomes for at least 9 months. After a long storage, the most stable formulations were those without CHOL. Singlet molecular oxygen values ranged between 0.10 and 0.26. These values were higher than other zinc(II) phthalocyanines incorporated into dimyristoyl phosphatidylcholine (DMPC) liposomes or Tween 80. © 2012 Elsevier B.V.
format JOUR
author López Zeballos, N.C.
García Vior, M.C.
Awruch, J.
Dicelio, L.E.
author_facet López Zeballos, N.C.
García Vior, M.C.
Awruch, J.
Dicelio, L.E.
author_sort López Zeballos, N.C.
title An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes
title_short An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes
title_full An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes
title_fullStr An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes
title_full_unstemmed An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes
title_sort exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(ii) phthalocyanine incorporated into liposomes
url http://hdl.handle.net/20.500.12110/paper_10106030_v235_n_p7_LopezZeballos
work_keys_str_mv AT lopezzeballosnc anexhaustivestudyofanovelsulfurlinkedadamantanetetrasubstitutedzinciiphthalocyanineincorporatedintoliposomes
AT garciaviormc anexhaustivestudyofanovelsulfurlinkedadamantanetetrasubstitutedzinciiphthalocyanineincorporatedintoliposomes
AT awruchj anexhaustivestudyofanovelsulfurlinkedadamantanetetrasubstitutedzinciiphthalocyanineincorporatedintoliposomes
AT diceliole anexhaustivestudyofanovelsulfurlinkedadamantanetetrasubstitutedzinciiphthalocyanineincorporatedintoliposomes
AT lopezzeballosnc exhaustivestudyofanovelsulfurlinkedadamantanetetrasubstitutedzinciiphthalocyanineincorporatedintoliposomes
AT garciaviormc exhaustivestudyofanovelsulfurlinkedadamantanetetrasubstitutedzinciiphthalocyanineincorporatedintoliposomes
AT awruchj exhaustivestudyofanovelsulfurlinkedadamantanetetrasubstitutedzinciiphthalocyanineincorporatedintoliposomes
AT diceliole exhaustivestudyofanovelsulfurlinkedadamantanetetrasubstitutedzinciiphthalocyanineincorporatedintoliposomes
_version_ 1807318270479433728

Ejemplares similares