Bottom-up gamma maintenance in various disorders
Maintained gamma band activity is a key element of higher brain function, participating in perception, executive function, and memory. The pedunculopontine nucleus (PPN), as part of the reticular activating system (RAS), is a major source of the “bottom-up” flow of gamma activity to higher regions....
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| Formato: | INPR |
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_09699961_v_n_p_GarciaRill |
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todo:paper_09699961_v_n_p_GarciaRill2023-10-03T15:55:33Z Bottom-up gamma maintenance in various disorders Garcia-Rill, E. Mahaffey, S. Hyde, J.R. Urbano, F.J. Alzheimer's disease Bipolar disorder Bottom-up gamma Coma Depression Mesencephalic locomotor region Neglect Parkinson's disease Pedunculopontine nucleus Reticular activating system Schizophrenia Top-down beta Maintained gamma band activity is a key element of higher brain function, participating in perception, executive function, and memory. The pedunculopontine nucleus (PPN), as part of the reticular activating system (RAS), is a major source of the “bottom-up” flow of gamma activity to higher regions. However, interruption of gamma band activity is associated with a number of neurological and psychiatric disorders. This review will focus on the role of the PPN in activating higher regions to induce arousal and descending pathways to modulate posture and locomotion. As such, PPN deep brain stimulation (DBS) can not only help regulate arousal and stepping, but continuous application may help maintain necessary levels of gamma band activity for a host of other brain processes. We will explore the potential future applications of PPN DBS for a number of disorders that are characterized by disturbances in gamma band maintenance. © 2018 INPR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09699961_v_n_p_GarciaRill |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Alzheimer's disease Bipolar disorder Bottom-up gamma Coma Depression Mesencephalic locomotor region Neglect Parkinson's disease Pedunculopontine nucleus Reticular activating system Schizophrenia Top-down beta |
| spellingShingle |
Alzheimer's disease Bipolar disorder Bottom-up gamma Coma Depression Mesencephalic locomotor region Neglect Parkinson's disease Pedunculopontine nucleus Reticular activating system Schizophrenia Top-down beta Garcia-Rill, E. Mahaffey, S. Hyde, J.R. Urbano, F.J. Bottom-up gamma maintenance in various disorders |
| topic_facet |
Alzheimer's disease Bipolar disorder Bottom-up gamma Coma Depression Mesencephalic locomotor region Neglect Parkinson's disease Pedunculopontine nucleus Reticular activating system Schizophrenia Top-down beta |
| description |
Maintained gamma band activity is a key element of higher brain function, participating in perception, executive function, and memory. The pedunculopontine nucleus (PPN), as part of the reticular activating system (RAS), is a major source of the “bottom-up” flow of gamma activity to higher regions. However, interruption of gamma band activity is associated with a number of neurological and psychiatric disorders. This review will focus on the role of the PPN in activating higher regions to induce arousal and descending pathways to modulate posture and locomotion. As such, PPN deep brain stimulation (DBS) can not only help regulate arousal and stepping, but continuous application may help maintain necessary levels of gamma band activity for a host of other brain processes. We will explore the potential future applications of PPN DBS for a number of disorders that are characterized by disturbances in gamma band maintenance. © 2018 |
| format |
INPR |
| author |
Garcia-Rill, E. Mahaffey, S. Hyde, J.R. Urbano, F.J. |
| author_facet |
Garcia-Rill, E. Mahaffey, S. Hyde, J.R. Urbano, F.J. |
| author_sort |
Garcia-Rill, E. |
| title |
Bottom-up gamma maintenance in various disorders |
| title_short |
Bottom-up gamma maintenance in various disorders |
| title_full |
Bottom-up gamma maintenance in various disorders |
| title_fullStr |
Bottom-up gamma maintenance in various disorders |
| title_full_unstemmed |
Bottom-up gamma maintenance in various disorders |
| title_sort |
bottom-up gamma maintenance in various disorders |
| url |
http://hdl.handle.net/20.500.12110/paper_09699961_v_n_p_GarciaRill |
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AT garciarille bottomupgammamaintenanceinvariousdisorders AT mahaffeys bottomupgammamaintenanceinvariousdisorders AT hydejr bottomupgammamaintenanceinvariousdisorders AT urbanofj bottomupgammamaintenanceinvariousdisorders |
| _version_ |
1807315531310563328 |