Influence of conformationally restricted pyrimidines on the activity of 10-23 DNAzymes

The catalytic core of a 10-23 DNAzyme was modified introducing conformationally restricted nucleosides such as (2′R)-, (2′S)-2′-deoxy-2′-C-methyluridine, (2′R)-, (2′S)-2′-deoxy-2′-C-methylcytidine, 2,2′-anhydrouridine and LNA-C, in one, two or three positions. Catalytic activities under pseudo first...

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Detalles Bibliográficos
Autores principales: Robaldo, L., Izzo, F., Dellafiore, M., Proietti, C., Elizalde, P.V., Montserrat, J.M., Iribarren, A.M.
Formato: JOUR
Materias:
2′-C-Methylnucleosides
Deoxyribozymes
DNA structures
DNAzymes
Modified nucleosides
2' deoxy 2' c methyl pyrimidine derivative
2' deoxy 2' c methylcytidine
2' deoxy 2' c methyluridine
2' methylcytidine
deoxyribozyme
pyrimidine derivative
short hairpin RNA
STAT3 protein
unclassified drug
article
breast cancer
cancer cell
catalysis
cell proliferation
concentration response
controlled study
enzyme activity
enzyme inhibition
enzyme kinetics
enzyme modification
enzyme stability
enzyme structure
enzyme synthesis
human
human cell
nucleic acid synthesis
protein conformation
protein expression
Antineoplastic Agents
Biocatalysis
Cell Proliferation
DNA, Catalytic
DNA, Single-Stranded
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Enzyme Activation
Humans
Molecular Conformation
Pyrimidines
STAT3 Transcription Factor
Structure-Activity Relationship
Tumor Cells, Cultured
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09680896_v20_n8_p2581_Robaldo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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