Translating the ‘Sugar Code’ into Immune and Vascular Signaling Programs
The vast range and complexity of glycan structures and their dynamic variations in health and disease have presented formidable challenges toward understanding the biological significance of these molecules. Despite these limitations, compelling evidence highlights a major role for galectins, a fami...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_09680004_v42_n4_p255_Cerliani |
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todo:paper_09680004_v42_n4_p255_Cerliani2023-10-03T15:55:10Z Translating the ‘Sugar Code’ into Immune and Vascular Signaling Programs Cerliani, J.P. Blidner, A.G. Toscano, M.A. Croci, D.O. Rabinovich, G.A. endothelial cells galectins glycans lymphoid cells myeloid cells binding protein galectin glycan glycan binding protein unclassified drug galectin polysaccharide B lymphocyte bone marrow carbohydrate analysis cardiovascular system cell function dendritic cell endocytosis endothelium eosinophil genetic engineering human immune system lymphoid tissue macrophage mast cell microglia model molecular interaction monocyte natural killer cell neutrophil nonhuman organism model protein aggregation Review signal transduction T lymphocyte chemistry immunology metabolism Endothelium Galectins Humans Immune System Polysaccharides Signal Transduction The vast range and complexity of glycan structures and their dynamic variations in health and disease have presented formidable challenges toward understanding the biological significance of these molecules. Despite these limitations, compelling evidence highlights a major role for galectins, a family of soluble glycan-binding proteins, as endogenous decoders that translate glycan-containing information into a broad spectrum of cellular responses by modulating receptor clustering, reorganization, endocytosis, and signaling. Here, we underscore pioneer findings and recent advances in understanding the biology of galectin–glycan interactions in myeloid, lymphoid, and endothelial compartments, highlighting important pathways by which these multivalent complexes control immune and vascular programs. Implementation of novel glycoanalytical approaches, as well as the use of genetically engineered cell and organism models, have allowed glycans and galectins to be explored across a range of cellular processes. © 2016 Elsevier Ltd Fil:Toscano, M.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Croci, D.O. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09680004_v42_n4_p255_Cerliani |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
endothelial cells galectins glycans lymphoid cells myeloid cells binding protein galectin glycan glycan binding protein unclassified drug galectin polysaccharide B lymphocyte bone marrow carbohydrate analysis cardiovascular system cell function dendritic cell endocytosis endothelium eosinophil genetic engineering human immune system lymphoid tissue macrophage mast cell microglia model molecular interaction monocyte natural killer cell neutrophil nonhuman organism model protein aggregation Review signal transduction T lymphocyte chemistry immunology metabolism Endothelium Galectins Humans Immune System Polysaccharides Signal Transduction |
| spellingShingle |
endothelial cells galectins glycans lymphoid cells myeloid cells binding protein galectin glycan glycan binding protein unclassified drug galectin polysaccharide B lymphocyte bone marrow carbohydrate analysis cardiovascular system cell function dendritic cell endocytosis endothelium eosinophil genetic engineering human immune system lymphoid tissue macrophage mast cell microglia model molecular interaction monocyte natural killer cell neutrophil nonhuman organism model protein aggregation Review signal transduction T lymphocyte chemistry immunology metabolism Endothelium Galectins Humans Immune System Polysaccharides Signal Transduction Cerliani, J.P. Blidner, A.G. Toscano, M.A. Croci, D.O. Rabinovich, G.A. Translating the ‘Sugar Code’ into Immune and Vascular Signaling Programs |
| topic_facet |
endothelial cells galectins glycans lymphoid cells myeloid cells binding protein galectin glycan glycan binding protein unclassified drug galectin polysaccharide B lymphocyte bone marrow carbohydrate analysis cardiovascular system cell function dendritic cell endocytosis endothelium eosinophil genetic engineering human immune system lymphoid tissue macrophage mast cell microglia model molecular interaction monocyte natural killer cell neutrophil nonhuman organism model protein aggregation Review signal transduction T lymphocyte chemistry immunology metabolism Endothelium Galectins Humans Immune System Polysaccharides Signal Transduction |
| description |
The vast range and complexity of glycan structures and their dynamic variations in health and disease have presented formidable challenges toward understanding the biological significance of these molecules. Despite these limitations, compelling evidence highlights a major role for galectins, a family of soluble glycan-binding proteins, as endogenous decoders that translate glycan-containing information into a broad spectrum of cellular responses by modulating receptor clustering, reorganization, endocytosis, and signaling. Here, we underscore pioneer findings and recent advances in understanding the biology of galectin–glycan interactions in myeloid, lymphoid, and endothelial compartments, highlighting important pathways by which these multivalent complexes control immune and vascular programs. Implementation of novel glycoanalytical approaches, as well as the use of genetically engineered cell and organism models, have allowed glycans and galectins to be explored across a range of cellular processes. © 2016 Elsevier Ltd |
| format |
JOUR |
| author |
Cerliani, J.P. Blidner, A.G. Toscano, M.A. Croci, D.O. Rabinovich, G.A. |
| author_facet |
Cerliani, J.P. Blidner, A.G. Toscano, M.A. Croci, D.O. Rabinovich, G.A. |
| author_sort |
Cerliani, J.P. |
| title |
Translating the ‘Sugar Code’ into Immune and Vascular Signaling Programs |
| title_short |
Translating the ‘Sugar Code’ into Immune and Vascular Signaling Programs |
| title_full |
Translating the ‘Sugar Code’ into Immune and Vascular Signaling Programs |
| title_fullStr |
Translating the ‘Sugar Code’ into Immune and Vascular Signaling Programs |
| title_full_unstemmed |
Translating the ‘Sugar Code’ into Immune and Vascular Signaling Programs |
| title_sort |
translating the ‘sugar code’ into immune and vascular signaling programs |
| url |
http://hdl.handle.net/20.500.12110/paper_09680004_v42_n4_p255_Cerliani |
| work_keys_str_mv |
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| _version_ |
1807322834642403328 |