Juvenile hormone synthesis: "esterify then epoxidize" or " epoxidize then esterify" ? Insights from the structural characterization of juvenile hormone acid methyltransferase

Juvenile hormones (JHs) play key roles in regulating metamorphosis and reproduction in insects. The last two steps of JH synthesis diverge depending on the insect order. In Lepidoptera, epoxidation by a P450 monooxygenase precedes esterification by a juvenile hormone acid methyltransferase (JHAMT)....

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Detalles Bibliográficos
Autores principales: Defelipe, L.A., Dolghih, E., Roitberg, A.E., Nouzova, M., Mayoral, J.G., Noriega, F.G., Turjanski, A.G.
Formato: JOUR
Materias:
Farnesoic acid
Homology modeling
Juvenile hormone acid
Juvenile hormone synthesis
Methyltransferase
P450 epoxidase
farnesoic acid
insect protein
juvenile hormone
methyltransferase
unsaturated fatty acid
Aedes
amino acid sequence
animal
article
binding site
biosynthesis
chemical structure
chemistry
enzyme specificity
enzymology
genetics
insect
isomerism
metabolism
molecular genetics
protein processing
sequence alignment
Amino Acid Sequence
Animals
Binding Sites
Fatty Acids, Unsaturated
Insect Proteins
Insects
Isomerism
Juvenile Hormones
Methyltransferases
Models, Molecular
Molecular Sequence Data
Protein Processing, Post-Translational
Sequence Alignment
Substrate Specificity
Aedes aegypti
Anopheles gambiae
Bombyx mori
Coleoptera
Dictyoptera
Diptera
Drosophila melanogaster
Hexapoda
Lepidoptera
Orthoptera
Tribolium (beetle)
Tribolium castaneum
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09651748_v41_n4_p228_Defelipe
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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