Drosophila learn opposing components of a compound food stimulus

Dopaminergic neurons provide value signals in mammals and insects [1-3]. During Drosophila olfactory learning, distinct subsets of dopaminergic neurons appear to assign either positive or negative value to odor representations in mushroom body neurons [4-9]. However, it is not known how flies evalua...

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Autores principales:	Das, G., Klappenbach, M., Vrontou, E., Perisse, E., Clark, C.M., Burke, C.J., Waddell, S.
Formato:	JOUR
Materias:	Basidiomycota Hexapoda Mammalia carbohydrate diethyltoluamide animal appetite avoidance behavior conditioned reflex Drosophila melanogaster female learning male metabolism odor physiology smelling Animals Appetitive Behavior Avoidance Learning Carbohydrates Conditioning, Classical DEET Female Learning Male Odors Olfactory Perception
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_09609822_v24_n15_p1723_Das
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_09609822_v24_n15_p1723_Das
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spelling	todo:paper_09609822_v24_n15_p1723_Das2023-10-03T15:54:06Z Drosophila learn opposing components of a compound food stimulus Das, G. Klappenbach, M. Vrontou, E. Perisse, E. Clark, C.M. Burke, C.J. Waddell, S. Basidiomycota Hexapoda Mammalia carbohydrate diethyltoluamide animal appetite avoidance behavior conditioned reflex Drosophila melanogaster female learning male metabolism odor physiology smelling Animals Appetitive Behavior Avoidance Learning Carbohydrates Conditioning, Classical DEET Drosophila melanogaster Female Learning Male Odors Olfactory Perception Dopaminergic neurons provide value signals in mammals and insects [1-3]. During Drosophila olfactory learning, distinct subsets of dopaminergic neurons appear to assign either positive or negative value to odor representations in mushroom body neurons [4-9]. However, it is not known how flies evaluate substances that have mixed valence. Here we show that flies form short-lived aversive olfactory memories when trained with odors and sugars that are contaminated with the common insect repellent DEET. This DEET-aversive learning required the MB-MP1 dopaminergic neurons that are also required for shock learning [7]. Moreover, differential conditioning with DEET versus shock suggests that formation of these distinct aversive olfactory memories relies on a common negatively reinforcing dopaminergic mechanism. Surprisingly, as time passed after training, the behavior of DEET-sugar-trained flies reversed from conditioned odor avoidance into odor approach. In addition, flies that were compromised for reward learning exhibited a more robust and longer-lived aversive-DEET memory. These data demonstrate that flies independently process the DEET and sugar components to form parallel aversive and appetitive olfactory memories, with distinct kinetics, that compete to guide learned behavior. © 2014 The Authors. Fil:Klappenbach, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09609822_v24_n15_p1723_Das
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Basidiomycota Hexapoda Mammalia carbohydrate diethyltoluamide animal appetite avoidance behavior conditioned reflex Drosophila melanogaster female learning male metabolism odor physiology smelling Animals Appetitive Behavior Avoidance Learning Carbohydrates Conditioning, Classical DEET Drosophila melanogaster Female Learning Male Odors Olfactory Perception
spellingShingle	Basidiomycota Hexapoda Mammalia carbohydrate diethyltoluamide animal appetite avoidance behavior conditioned reflex Drosophila melanogaster female learning male metabolism odor physiology smelling Animals Appetitive Behavior Avoidance Learning Carbohydrates Conditioning, Classical DEET Drosophila melanogaster Female Learning Male Odors Olfactory Perception Das, G. Klappenbach, M. Vrontou, E. Perisse, E. Clark, C.M. Burke, C.J. Waddell, S. Drosophila learn opposing components of a compound food stimulus
topic_facet	Basidiomycota Hexapoda Mammalia carbohydrate diethyltoluamide animal appetite avoidance behavior conditioned reflex Drosophila melanogaster female learning male metabolism odor physiology smelling Animals Appetitive Behavior Avoidance Learning Carbohydrates Conditioning, Classical DEET Drosophila melanogaster Female Learning Male Odors Olfactory Perception
description	Dopaminergic neurons provide value signals in mammals and insects [1-3]. During Drosophila olfactory learning, distinct subsets of dopaminergic neurons appear to assign either positive or negative value to odor representations in mushroom body neurons [4-9]. However, it is not known how flies evaluate substances that have mixed valence. Here we show that flies form short-lived aversive olfactory memories when trained with odors and sugars that are contaminated with the common insect repellent DEET. This DEET-aversive learning required the MB-MP1 dopaminergic neurons that are also required for shock learning [7]. Moreover, differential conditioning with DEET versus shock suggests that formation of these distinct aversive olfactory memories relies on a common negatively reinforcing dopaminergic mechanism. Surprisingly, as time passed after training, the behavior of DEET-sugar-trained flies reversed from conditioned odor avoidance into odor approach. In addition, flies that were compromised for reward learning exhibited a more robust and longer-lived aversive-DEET memory. These data demonstrate that flies independently process the DEET and sugar components to form parallel aversive and appetitive olfactory memories, with distinct kinetics, that compete to guide learned behavior. © 2014 The Authors.
format	JOUR
author	Das, G. Klappenbach, M. Vrontou, E. Perisse, E. Clark, C.M. Burke, C.J. Waddell, S.
author_facet	Das, G. Klappenbach, M. Vrontou, E. Perisse, E. Clark, C.M. Burke, C.J. Waddell, S.
author_sort	Das, G.
title	Drosophila learn opposing components of a compound food stimulus
title_short	Drosophila learn opposing components of a compound food stimulus
title_full	Drosophila learn opposing components of a compound food stimulus
title_fullStr	Drosophila learn opposing components of a compound food stimulus
title_full_unstemmed	Drosophila learn opposing components of a compound food stimulus
title_sort	drosophila learn opposing components of a compound food stimulus
url	http://hdl.handle.net/20.500.12110/paper_09609822_v24_n15_p1723_Das
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_version_	1807315409252122624

Drosophila learn opposing components of a compound food stimulus

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