Modified ribavirin analogues as antiviral agents against Junín virus

In this work, several ribavirin analogues were synthesized and incorporated into a multivalent arrangement. Both were subsequently modified by the addition of polyhydroxylated residues. Their antiviral activity was tested against Junín virus, etiological agent responsible of Argentine hemorrhagic fe...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Contin, M., Sepúlveda, C., Fascio, M., Stortz, C.A., Damonte, E.B., D'Accorso, N.B.
Formato: JOUR
Materias:
1,2,3-Triazole ribose conjugates
Antiviral
Click chemistry
Junín virus
ribavirin
antiviral activity
Argentine hemorrhagic fever
Article
cell viability
drug conformation
drug determination
drug efficacy
drug selectivity
drug structure
EC50
Junin virus
nonhuman
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0960894X_v29_n4_p556_Contin
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:In this work, several ribavirin analogues were synthesized and incorporated into a multivalent arrangement. Both were subsequently modified by the addition of polyhydroxylated residues. Their antiviral activity was tested against Junín virus, etiological agent responsible of Argentine hemorrhagic fever. Some compounds inhibited Junín virus in the range of 13.2–389.1 µM. Two modified ribavirin analogues presented an effective concentration comparable to ribavirin but with a higher selectivity index. © 2019 Elsevier Ltd

Ejemplares similares