Modified ribavirin analogues as antiviral agents against Junín virus

In this work, several ribavirin analogues were synthesized and incorporated into a multivalent arrangement. Both were subsequently modified by the addition of polyhydroxylated residues. Their antiviral activity was tested against Junín virus, etiological agent responsible of Argentine hemorrhagic fe...

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Autores principales: Contin, M., Sepúlveda, C., Fascio, M., Stortz, C.A., Damonte, E.B., D'Accorso, N.B.
Formato: JOUR
Materias:
1,2,3-Triazole ribose conjugates
Antiviral
Click chemistry
Junín virus
ribavirin
antiviral activity
Argentine hemorrhagic fever
Article
cell viability
drug conformation
drug determination
drug efficacy
drug selectivity
drug structure
EC50
Junin virus
nonhuman
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0960894X_v29_n4_p556_Contin
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_0960894X_v29_n4_p556_Contin
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spelling todo:paper_0960894X_v29_n4_p556_Contin2023-10-03T15:54:03Z Modified ribavirin analogues as antiviral agents against Junín virus Contin, M. Sepúlveda, C. Fascio, M. Stortz, C.A. Damonte, E.B. D'Accorso, N.B. 1,2,3-Triazole ribose conjugates Antiviral Click chemistry Junín virus ribavirin antiviral activity Argentine hemorrhagic fever Article cell viability drug conformation drug determination drug efficacy drug selectivity drug structure EC50 Junin virus nonhuman In this work, several ribavirin analogues were synthesized and incorporated into a multivalent arrangement. Both were subsequently modified by the addition of polyhydroxylated residues. Their antiviral activity was tested against Junín virus, etiological agent responsible of Argentine hemorrhagic fever. Some compounds inhibited Junín virus in the range of 13.2–389.1 µM. Two modified ribavirin analogues presented an effective concentration comparable to ribavirin but with a higher selectivity index. © 2019 Elsevier Ltd JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0960894X_v29_n4_p556_Contin
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic 1,2,3-Triazole ribose conjugates
Antiviral
Click chemistry
Junín virus
ribavirin
antiviral activity
Argentine hemorrhagic fever
Article
cell viability
drug conformation
drug determination
drug efficacy
drug selectivity
drug structure
EC50
Junin virus
nonhuman
spellingShingle 1,2,3-Triazole ribose conjugates
Antiviral
Click chemistry
Junín virus
ribavirin
antiviral activity
Argentine hemorrhagic fever
Article
cell viability
drug conformation
drug determination
drug efficacy
drug selectivity
drug structure
EC50
Junin virus
nonhuman
Contin, M.
Sepúlveda, C.
Fascio, M.
Stortz, C.A.
Damonte, E.B.
D'Accorso, N.B.
Modified ribavirin analogues as antiviral agents against Junín virus
topic_facet 1,2,3-Triazole ribose conjugates
Antiviral
Click chemistry
Junín virus
ribavirin
antiviral activity
Argentine hemorrhagic fever
Article
cell viability
drug conformation
drug determination
drug efficacy
drug selectivity
drug structure
EC50
Junin virus
nonhuman
description In this work, several ribavirin analogues were synthesized and incorporated into a multivalent arrangement. Both were subsequently modified by the addition of polyhydroxylated residues. Their antiviral activity was tested against Junín virus, etiological agent responsible of Argentine hemorrhagic fever. Some compounds inhibited Junín virus in the range of 13.2–389.1 µM. Two modified ribavirin analogues presented an effective concentration comparable to ribavirin but with a higher selectivity index. © 2019 Elsevier Ltd
format JOUR
author Contin, M.
Sepúlveda, C.
Fascio, M.
Stortz, C.A.
Damonte, E.B.
D'Accorso, N.B.
author_facet Contin, M.
Sepúlveda, C.
Fascio, M.
Stortz, C.A.
Damonte, E.B.
D'Accorso, N.B.
author_sort Contin, M.
title Modified ribavirin analogues as antiviral agents against Junín virus
title_short Modified ribavirin analogues as antiviral agents against Junín virus
title_full Modified ribavirin analogues as antiviral agents against Junín virus
title_fullStr Modified ribavirin analogues as antiviral agents against Junín virus
title_full_unstemmed Modified ribavirin analogues as antiviral agents against Junín virus
title_sort modified ribavirin analogues as antiviral agents against junín virus
url http://hdl.handle.net/20.500.12110/paper_0960894X_v29_n4_p556_Contin
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AT fasciom modifiedribavirinanaloguesasantiviralagentsagainstjuninvirus
AT stortzca modifiedribavirinanaloguesasantiviralagentsagainstjuninvirus
AT damonteeb modifiedribavirinanaloguesasantiviralagentsagainstjuninvirus
AT daccorsonb modifiedribavirinanaloguesasantiviralagentsagainstjuninvirus
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