Galactofuranose-containing glycoconjugates in trypanosomatids

Galactofuranose has been characterized in glycoinositolphospholipid (GIPL) anchor-like structures having a glycerolipid or a ceramide, as in lipopeptidophosphoglycan (LPPG) of Trypanosoma cruzi, in the oligosaccharide core of lipophosphoglycan (LPG) of Leishmania species, and also modifying high-man...

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Autores principales: De Lederkremer, R.M., Colli, W.
Formato: JOUR
Materias:
Gangliosides
HPTLC-immunostaining
Platelets
Selectin ligands
Slex
glycoconjugate
glycoprotein
lipopeptide
carbohydrate analysis
chemical structure
leishmania
priority journal
review
trypanosoma cruzi
Animal
Antibodies, Protozoan
Antigens, Protozoan
Carbohydrate Sequence
Galactose
Glycoconjugates
Glycoproteins
Immune Sera
Molecular Sequence Data
Polysaccharides
Support, Non-U.S. Gov't
Trypanosomatina
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09596658_v5_n6_p547_DeLederkremer
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_09596658_v5_n6_p547_DeLederkremer
record_format dspace
spelling todo:paper_09596658_v5_n6_p547_DeLederkremer2023-10-03T15:53:09Z Galactofuranose-containing glycoconjugates in trypanosomatids De Lederkremer, R.M. Colli, W. Gangliosides HPTLC-immunostaining Platelets Selectin ligands Slex glycoconjugate glycoprotein lipopeptide carbohydrate analysis chemical structure leishmania priority journal review trypanosoma cruzi Animal Antibodies, Protozoan Antigens, Protozoan Carbohydrate Sequence Galactose Glycoconjugates Glycoproteins Immune Sera Molecular Sequence Data Polysaccharides Support, Non-U.S. Gov't Trypanosomatina Galactofuranose has been characterized in glycoinositolphospholipid (GIPL) anchor-like structures having a glycerolipid or a ceramide, as in lipopeptidophosphoglycan (LPPG) of Trypanosoma cruzi, in the oligosaccharide core of lipophosphoglycan (LPG) of Leishmania species, and also modifying high-mannose chains of trypanosomatid glycoproteins. Galactofuranose is usually present linked β1→3 to Man, either as a terminal non-reducing unit, like in LPPG, or in the middle of the oligosaccharide core, as in LPG. The presence in protozoan parasites of galactose in the furanose configuration is a feature which deserves further attention since the mammalian hosts donot appear to produce glycoconjugates containing this structural unit. For that reason, hosts produceantibodies against galactofuranose, which may turn out to be important in understanding the pathogenesis and in the development of diagnostic methods. The metabolic pathways involved in the attachment to or removal of galactofuranose from glycoconjugates have not yet been elucidated. This is an area ofincipient research, but of growing importance, since it will foster the design of inhibitors which may prove to be useful for the treatment of disease. © 1995 Oxford University Press. Fil:De Lederkremer, R.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09596658_v5_n6_p547_DeLederkremer
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Gangliosides
HPTLC-immunostaining
Platelets
Selectin ligands
Slex
glycoconjugate
glycoprotein
lipopeptide
carbohydrate analysis
chemical structure
leishmania
priority journal
review
trypanosoma cruzi
Animal
Antibodies, Protozoan
Antigens, Protozoan
Carbohydrate Sequence
Galactose
Glycoconjugates
Glycoproteins
Immune Sera
Molecular Sequence Data
Polysaccharides
Support, Non-U.S. Gov't
Trypanosomatina
spellingShingle Gangliosides
HPTLC-immunostaining
Platelets
Selectin ligands
Slex
glycoconjugate
glycoprotein
lipopeptide
carbohydrate analysis
chemical structure
leishmania
priority journal
review
trypanosoma cruzi
Animal
Antibodies, Protozoan
Antigens, Protozoan
Carbohydrate Sequence
Galactose
Glycoconjugates
Glycoproteins
Immune Sera
Molecular Sequence Data
Polysaccharides
Support, Non-U.S. Gov't
Trypanosomatina
De Lederkremer, R.M.
Colli, W.
Galactofuranose-containing glycoconjugates in trypanosomatids
topic_facet Gangliosides
HPTLC-immunostaining
Platelets
Selectin ligands
Slex
glycoconjugate
glycoprotein
lipopeptide
carbohydrate analysis
chemical structure
leishmania
priority journal
review
trypanosoma cruzi
Animal
Antibodies, Protozoan
Antigens, Protozoan
Carbohydrate Sequence
Galactose
Glycoconjugates
Glycoproteins
Immune Sera
Molecular Sequence Data
Polysaccharides
Support, Non-U.S. Gov't
Trypanosomatina
description Galactofuranose has been characterized in glycoinositolphospholipid (GIPL) anchor-like structures having a glycerolipid or a ceramide, as in lipopeptidophosphoglycan (LPPG) of Trypanosoma cruzi, in the oligosaccharide core of lipophosphoglycan (LPG) of Leishmania species, and also modifying high-mannose chains of trypanosomatid glycoproteins. Galactofuranose is usually present linked β1→3 to Man, either as a terminal non-reducing unit, like in LPPG, or in the middle of the oligosaccharide core, as in LPG. The presence in protozoan parasites of galactose in the furanose configuration is a feature which deserves further attention since the mammalian hosts donot appear to produce glycoconjugates containing this structural unit. For that reason, hosts produceantibodies against galactofuranose, which may turn out to be important in understanding the pathogenesis and in the development of diagnostic methods. The metabolic pathways involved in the attachment to or removal of galactofuranose from glycoconjugates have not yet been elucidated. This is an area ofincipient research, but of growing importance, since it will foster the design of inhibitors which may prove to be useful for the treatment of disease. © 1995 Oxford University Press.
format JOUR
author De Lederkremer, R.M.
Colli, W.
author_facet De Lederkremer, R.M.
Colli, W.
author_sort De Lederkremer, R.M.
title Galactofuranose-containing glycoconjugates in trypanosomatids
title_short Galactofuranose-containing glycoconjugates in trypanosomatids
title_full Galactofuranose-containing glycoconjugates in trypanosomatids
title_fullStr Galactofuranose-containing glycoconjugates in trypanosomatids
title_full_unstemmed Galactofuranose-containing glycoconjugates in trypanosomatids
title_sort galactofuranose-containing glycoconjugates in trypanosomatids
url http://hdl.handle.net/20.500.12110/paper_09596658_v5_n6_p547_DeLederkremer
work_keys_str_mv AT delederkremerrm galactofuranosecontainingglycoconjugatesintrypanosomatids
AT colliw galactofuranosecontainingglycoconjugatesintrypanosomatids
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