Galectin-8: A matricellular lectin with key roles in angiogenesis

Galectin-8 (gal-8) is a "tandem-repeat"-type galectin, containing two carbohydrate recognition domains connected by a linker peptide. gal-8 is expressed both in the cytoplasm and nucleus in vascular endothelial cells (ECs) from normal and tumor-associated blood vessels, and in lymphatic en...

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Detalles Bibliográficos
Autores principales: Troncoso, M.F., Ferragut, F., Bacigalupo, M.L., Delgado, V.M.C., Nugnes, L.G., Gentilini, L., Laderach, D., Wolfenstein-Todel, C., Compagno, D., Rabinovich, G.A., Elola, M.T.
Formato: JOUR
Materias:
Angiogenesis
CD166
Endothelium
Galectin-8
activated leukocyte cell adhesion molecule
galectin 8
Hermes antigen
integrin
podoplanin
ALCAM protein, human
fetoprotein
galectin
leukocyte antigen
LGALS8 protein, human
membrane protein
nerve cell adhesion molecule
PDPN protein, human
angiogenesis
Article
cell adhesion
cell migration
endothelium cell
human
lymph vessel endothelium
lymphangiogenesis
nonhuman
priority journal
protein protein interaction
serum
vascular endothelium
carcinogenesis
extracellular matrix
genetics
metabolism
metastasis
neoplasm
neovascularization (pathology)
pathology
Antigens, CD
Carcinogenesis
Cell Adhesion
Cell Adhesion Molecules, Neuronal
Endothelial Cells
Extracellular Matrix
Fetal Proteins
Galectins
Humans
Membrane Glycoproteins
Neoplasm Metastasis
Neoplasms
Neovascularization, Pathologic
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09596658_v24_n10_p907_Troncoso
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Galectin-8 (gal-8) is a "tandem-repeat"-type galectin, containing two carbohydrate recognition domains connected by a linker peptide. gal-8 is expressed both in the cytoplasm and nucleus in vascular endothelial cells (ECs) from normal and tumor-associated blood vessels, and in lymphatic endothelial cells. Herein, we describe a novel role for gal-8 in the regulation of vascular and lymphatic angiogenesis and provide evidence of its critical implications in tumor biology. Functional assays revealed central roles for gal-8 in the control of capillary-tube formation, EC migration and in vivo angiogenesis. So far, two endothelial ligands have been described for gal-8, namely podoplanin in lymphatic vessels and CD166 (ALCAM, activated leukocyte cell adhesion molecule) in vascular ECs. Other related gal-8 functions are also summarized here, including cell adhesion and migration, which collectively demonstrate the multi-functionality of this complex lectin. Thus, gal-8 is an important component of the angiogenesis network, and an essential molecule in the extracellular matrix by providing molecular anchoring to this surrounding matrix. The implications of gal-8 in tumor angiogenesis remain to be further explored, but it is exciting to speculate that modulating gal-8-glycan interactions could be used to block lymphatic-vascular connections vital for metastasis. © The Author 2014. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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