Galectin-8: A matricellular lectin with key roles in angiogenesis
Galectin-8 (gal-8) is a "tandem-repeat"-type galectin, containing two carbohydrate recognition domains connected by a linker peptide. gal-8 is expressed both in the cytoplasm and nucleus in vascular endothelial cells (ECs) from normal and tumor-associated blood vessels, and in lymphatic en...
Guardado en:
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_09596658_v24_n10_p907_Troncoso |
| Aporte de: |
| id |
todo:paper_09596658_v24_n10_p907_Troncoso |
|---|---|
| record_format |
dspace |
| spelling |
todo:paper_09596658_v24_n10_p907_Troncoso2023-10-03T15:53:06Z Galectin-8: A matricellular lectin with key roles in angiogenesis Troncoso, M.F. Ferragut, F. Bacigalupo, M.L. Delgado, V.M.C. Nugnes, L.G. Gentilini, L. Laderach, D. Wolfenstein-Todel, C. Compagno, D. Rabinovich, G.A. Elola, M.T. Angiogenesis CD166 Endothelium Galectin-8 activated leukocyte cell adhesion molecule galectin 8 Hermes antigen integrin podoplanin ALCAM protein, human fetoprotein galectin leukocyte antigen LGALS8 protein, human membrane protein nerve cell adhesion molecule PDPN protein, human angiogenesis Article cell adhesion cell migration endothelium cell human lymph vessel endothelium lymphangiogenesis nonhuman priority journal protein protein interaction serum vascular endothelium carcinogenesis extracellular matrix genetics metabolism metastasis neoplasm neovascularization (pathology) pathology Antigens, CD Carcinogenesis Cell Adhesion Cell Adhesion Molecules, Neuronal Endothelial Cells Extracellular Matrix Fetal Proteins Galectins Humans Membrane Glycoproteins Neoplasm Metastasis Neoplasms Neovascularization, Pathologic Galectin-8 (gal-8) is a "tandem-repeat"-type galectin, containing two carbohydrate recognition domains connected by a linker peptide. gal-8 is expressed both in the cytoplasm and nucleus in vascular endothelial cells (ECs) from normal and tumor-associated blood vessels, and in lymphatic endothelial cells. Herein, we describe a novel role for gal-8 in the regulation of vascular and lymphatic angiogenesis and provide evidence of its critical implications in tumor biology. Functional assays revealed central roles for gal-8 in the control of capillary-tube formation, EC migration and in vivo angiogenesis. So far, two endothelial ligands have been described for gal-8, namely podoplanin in lymphatic vessels and CD166 (ALCAM, activated leukocyte cell adhesion molecule) in vascular ECs. Other related gal-8 functions are also summarized here, including cell adhesion and migration, which collectively demonstrate the multi-functionality of this complex lectin. Thus, gal-8 is an important component of the angiogenesis network, and an essential molecule in the extracellular matrix by providing molecular anchoring to this surrounding matrix. The implications of gal-8 in tumor angiogenesis remain to be further explored, but it is exciting to speculate that modulating gal-8-glycan interactions could be used to block lymphatic-vascular connections vital for metastasis. © The Author 2014. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. Fil:Troncoso, M.F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Elola, M.T. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09596658_v24_n10_p907_Troncoso |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Angiogenesis CD166 Endothelium Galectin-8 activated leukocyte cell adhesion molecule galectin 8 Hermes antigen integrin podoplanin ALCAM protein, human fetoprotein galectin leukocyte antigen LGALS8 protein, human membrane protein nerve cell adhesion molecule PDPN protein, human angiogenesis Article cell adhesion cell migration endothelium cell human lymph vessel endothelium lymphangiogenesis nonhuman priority journal protein protein interaction serum vascular endothelium carcinogenesis extracellular matrix genetics metabolism metastasis neoplasm neovascularization (pathology) pathology Antigens, CD Carcinogenesis Cell Adhesion Cell Adhesion Molecules, Neuronal Endothelial Cells Extracellular Matrix Fetal Proteins Galectins Humans Membrane Glycoproteins Neoplasm Metastasis Neoplasms Neovascularization, Pathologic |
| spellingShingle |
Angiogenesis CD166 Endothelium Galectin-8 activated leukocyte cell adhesion molecule galectin 8 Hermes antigen integrin podoplanin ALCAM protein, human fetoprotein galectin leukocyte antigen LGALS8 protein, human membrane protein nerve cell adhesion molecule PDPN protein, human angiogenesis Article cell adhesion cell migration endothelium cell human lymph vessel endothelium lymphangiogenesis nonhuman priority journal protein protein interaction serum vascular endothelium carcinogenesis extracellular matrix genetics metabolism metastasis neoplasm neovascularization (pathology) pathology Antigens, CD Carcinogenesis Cell Adhesion Cell Adhesion Molecules, Neuronal Endothelial Cells Extracellular Matrix Fetal Proteins Galectins Humans Membrane Glycoproteins Neoplasm Metastasis Neoplasms Neovascularization, Pathologic Troncoso, M.F. Ferragut, F. Bacigalupo, M.L. Delgado, V.M.C. Nugnes, L.G. Gentilini, L. Laderach, D. Wolfenstein-Todel, C. Compagno, D. Rabinovich, G.A. Elola, M.T. Galectin-8: A matricellular lectin with key roles in angiogenesis |
| topic_facet |
Angiogenesis CD166 Endothelium Galectin-8 activated leukocyte cell adhesion molecule galectin 8 Hermes antigen integrin podoplanin ALCAM protein, human fetoprotein galectin leukocyte antigen LGALS8 protein, human membrane protein nerve cell adhesion molecule PDPN protein, human angiogenesis Article cell adhesion cell migration endothelium cell human lymph vessel endothelium lymphangiogenesis nonhuman priority journal protein protein interaction serum vascular endothelium carcinogenesis extracellular matrix genetics metabolism metastasis neoplasm neovascularization (pathology) pathology Antigens, CD Carcinogenesis Cell Adhesion Cell Adhesion Molecules, Neuronal Endothelial Cells Extracellular Matrix Fetal Proteins Galectins Humans Membrane Glycoproteins Neoplasm Metastasis Neoplasms Neovascularization, Pathologic |
| description |
Galectin-8 (gal-8) is a "tandem-repeat"-type galectin, containing two carbohydrate recognition domains connected by a linker peptide. gal-8 is expressed both in the cytoplasm and nucleus in vascular endothelial cells (ECs) from normal and tumor-associated blood vessels, and in lymphatic endothelial cells. Herein, we describe a novel role for gal-8 in the regulation of vascular and lymphatic angiogenesis and provide evidence of its critical implications in tumor biology. Functional assays revealed central roles for gal-8 in the control of capillary-tube formation, EC migration and in vivo angiogenesis. So far, two endothelial ligands have been described for gal-8, namely podoplanin in lymphatic vessels and CD166 (ALCAM, activated leukocyte cell adhesion molecule) in vascular ECs. Other related gal-8 functions are also summarized here, including cell adhesion and migration, which collectively demonstrate the multi-functionality of this complex lectin. Thus, gal-8 is an important component of the angiogenesis network, and an essential molecule in the extracellular matrix by providing molecular anchoring to this surrounding matrix. The implications of gal-8 in tumor angiogenesis remain to be further explored, but it is exciting to speculate that modulating gal-8-glycan interactions could be used to block lymphatic-vascular connections vital for metastasis. © The Author 2014. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
| format |
JOUR |
| author |
Troncoso, M.F. Ferragut, F. Bacigalupo, M.L. Delgado, V.M.C. Nugnes, L.G. Gentilini, L. Laderach, D. Wolfenstein-Todel, C. Compagno, D. Rabinovich, G.A. Elola, M.T. |
| author_facet |
Troncoso, M.F. Ferragut, F. Bacigalupo, M.L. Delgado, V.M.C. Nugnes, L.G. Gentilini, L. Laderach, D. Wolfenstein-Todel, C. Compagno, D. Rabinovich, G.A. Elola, M.T. |
| author_sort |
Troncoso, M.F. |
| title |
Galectin-8: A matricellular lectin with key roles in angiogenesis |
| title_short |
Galectin-8: A matricellular lectin with key roles in angiogenesis |
| title_full |
Galectin-8: A matricellular lectin with key roles in angiogenesis |
| title_fullStr |
Galectin-8: A matricellular lectin with key roles in angiogenesis |
| title_full_unstemmed |
Galectin-8: A matricellular lectin with key roles in angiogenesis |
| title_sort |
galectin-8: a matricellular lectin with key roles in angiogenesis |
| url |
http://hdl.handle.net/20.500.12110/paper_09596658_v24_n10_p907_Troncoso |
| work_keys_str_mv |
AT troncosomf galectin8amatricellularlectinwithkeyrolesinangiogenesis AT ferragutf galectin8amatricellularlectinwithkeyrolesinangiogenesis AT bacigalupoml galectin8amatricellularlectinwithkeyrolesinangiogenesis AT delgadovmc galectin8amatricellularlectinwithkeyrolesinangiogenesis AT nugneslg galectin8amatricellularlectinwithkeyrolesinangiogenesis AT gentilinil galectin8amatricellularlectinwithkeyrolesinangiogenesis AT laderachd galectin8amatricellularlectinwithkeyrolesinangiogenesis AT wolfensteintodelc galectin8amatricellularlectinwithkeyrolesinangiogenesis AT compagnod galectin8amatricellularlectinwithkeyrolesinangiogenesis AT rabinovichga galectin8amatricellularlectinwithkeyrolesinangiogenesis AT elolamt galectin8amatricellularlectinwithkeyrolesinangiogenesis |
| _version_ |
1807320008874786816 |