Evidence for the involvement of hippocampal CO production in the acquisition and consolidation of inhibitory avoidance learning
Carbon monoxide (CO), produced through the action of haem oxygenase (HO) isoenzymes, has been recently postulated as a retrograde messenger in the early stages of long-term potentiation (LTP). In the present study, rats submitted to an inhibitory avoidance task there is a significant increase (76%)...
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todo:paper_09594965_v6_n3_p516_Bernabeu2023-10-03T15:53:00Z Evidence for the involvement of hippocampal CO production in the acquisition and consolidation of inhibitory avoidance learning Bernabeu, R. Princ, F. De Stein, M.L. Fin, C. Ana Juknat, A. Batile, A. Ivan, I. Medina, J.H. Amnesia CO Haem oxygenase Hippocampus Inhibitory avoidance Zn-pro-toporphyrin-ix carbon monoxide oxygenase protoporphyrin zinc animal experiment animal tissue article avoidance behavior brain cortex cerebellum controlled study hippocampus learning male memory nonhuman priority journal rat Animal Avoidance Learning Carbon Monoxide Heme Oxygenase (Decyclizing) Hippocampus Long-Term Potentiation Male Rats Rats, Wistar Support, Non-U.S. Gov't Time Factors Zinc Carbon monoxide (CO), produced through the action of haem oxygenase (HO) isoenzymes, has been recently postulated as a retrograde messenger in the early stages of long-term potentiation (LTP). In the present study, rats submitted to an inhibitory avoidance task there is a significant increase (76%) in hippocampal HO activity immediately after training (0 min), but not at 60 min posttraining. No changes were observed in cerebral cortical and cerebellar HO activity. Bilateral intrahippocampal infusion of the HO inhibitor zinc-protoporphyrin-IX (ZnPP) (2 µg side-1) caused full amnesia for inhibitory avoidance when given 10 min before training or immediately after training, but not 60 min after training. These findings provide evidence that CO production in the hippocampus is important for the early stages of memory processing of an inhibitory avoidance training. © Rapid Communications of Oxford Ltd. Fil:Bernabeu, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Princ, F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09594965_v6_n3_p516_Bernabeu |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Amnesia CO Haem oxygenase Hippocampus Inhibitory avoidance Zn-pro-toporphyrin-ix carbon monoxide oxygenase protoporphyrin zinc animal experiment animal tissue article avoidance behavior brain cortex cerebellum controlled study hippocampus learning male memory nonhuman priority journal rat Animal Avoidance Learning Carbon Monoxide Heme Oxygenase (Decyclizing) Hippocampus Long-Term Potentiation Male Rats Rats, Wistar Support, Non-U.S. Gov't Time Factors Zinc |
| spellingShingle |
Amnesia CO Haem oxygenase Hippocampus Inhibitory avoidance Zn-pro-toporphyrin-ix carbon monoxide oxygenase protoporphyrin zinc animal experiment animal tissue article avoidance behavior brain cortex cerebellum controlled study hippocampus learning male memory nonhuman priority journal rat Animal Avoidance Learning Carbon Monoxide Heme Oxygenase (Decyclizing) Hippocampus Long-Term Potentiation Male Rats Rats, Wistar Support, Non-U.S. Gov't Time Factors Zinc Bernabeu, R. Princ, F. De Stein, M.L. Fin, C. Ana Juknat, A. Batile, A. Ivan, I. Medina, J.H. Evidence for the involvement of hippocampal CO production in the acquisition and consolidation of inhibitory avoidance learning |
| topic_facet |
Amnesia CO Haem oxygenase Hippocampus Inhibitory avoidance Zn-pro-toporphyrin-ix carbon monoxide oxygenase protoporphyrin zinc animal experiment animal tissue article avoidance behavior brain cortex cerebellum controlled study hippocampus learning male memory nonhuman priority journal rat Animal Avoidance Learning Carbon Monoxide Heme Oxygenase (Decyclizing) Hippocampus Long-Term Potentiation Male Rats Rats, Wistar Support, Non-U.S. Gov't Time Factors Zinc |
| description |
Carbon monoxide (CO), produced through the action of haem oxygenase (HO) isoenzymes, has been recently postulated as a retrograde messenger in the early stages of long-term potentiation (LTP). In the present study, rats submitted to an inhibitory avoidance task there is a significant increase (76%) in hippocampal HO activity immediately after training (0 min), but not at 60 min posttraining. No changes were observed in cerebral cortical and cerebellar HO activity. Bilateral intrahippocampal infusion of the HO inhibitor zinc-protoporphyrin-IX (ZnPP) (2 µg side-1) caused full amnesia for inhibitory avoidance when given 10 min before training or immediately after training, but not 60 min after training. These findings provide evidence that CO production in the hippocampus is important for the early stages of memory processing of an inhibitory avoidance training. © Rapid Communications of Oxford Ltd. |
| format |
JOUR |
| author |
Bernabeu, R. Princ, F. De Stein, M.L. Fin, C. Ana Juknat, A. Batile, A. Ivan, I. Medina, J.H. |
| author_facet |
Bernabeu, R. Princ, F. De Stein, M.L. Fin, C. Ana Juknat, A. Batile, A. Ivan, I. Medina, J.H. |
| author_sort |
Bernabeu, R. |
| title |
Evidence for the involvement of hippocampal CO production in the acquisition and consolidation of inhibitory avoidance learning |
| title_short |
Evidence for the involvement of hippocampal CO production in the acquisition and consolidation of inhibitory avoidance learning |
| title_full |
Evidence for the involvement of hippocampal CO production in the acquisition and consolidation of inhibitory avoidance learning |
| title_fullStr |
Evidence for the involvement of hippocampal CO production in the acquisition and consolidation of inhibitory avoidance learning |
| title_full_unstemmed |
Evidence for the involvement of hippocampal CO production in the acquisition and consolidation of inhibitory avoidance learning |
| title_sort |
evidence for the involvement of hippocampal co production in the acquisition and consolidation of inhibitory avoidance learning |
| url |
http://hdl.handle.net/20.500.12110/paper_09594965_v6_n3_p516_Bernabeu |
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