Molecular transduction mechanisms of cytokine-hormone interactions: Role of gp130 cytokines
Highly sophisticated mechanisms confer on the immune system the capacity to respond with a certain degree of autonomy. However, the final outcome of an immune response depends on the interaction of the immune system with other systems. The immune and neuroendocrine systems have an intimate cross-com...
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todo:paper_09580670_v92_n5_p801_Gerez2023-10-03T15:52:37Z Molecular transduction mechanisms of cytokine-hormone interactions: Role of gp130 cytokines Gerez, J. Bonfiglio, J. Sosa, S. Giacomini, D. Acuña, M. Carbia Nagashima, A. Perone, M.J. Silberstein, S. Renner, U. Stalla, G.K. Arzt, E. ciliary neurotrophic factor ciliary neurotrophic factor receptor corticotropin cytokine receptor glycoprotein gp 130 interleukin 11 interleukin 11 receptor interleukin 6 interleukin 6 receptor leukemia inhibitory factor oncostatin M prolactin steroid hormone adenohypophysis cell growth chronic inflammation conference paper corticotropin release cytokine production endocrine system environmental change genetic transduction hormone synthesis human humoral immunity hypophysis cell hypophysis gonad system hypothalamus immune system immunity immunopathology neuroendocrine system nonhuman protein expression protein function protein interaction signal transduction Animals Cytokine Receptor gp130 Cytokines Hormones Humans Neuroimmunomodulation Neurosecretory Systems Signal Transduction Highly sophisticated mechanisms confer on the immune system the capacity to respond with a certain degree of autonomy. However, the final outcome of an immune response depends on the interaction of the immune system with other systems. The immune and neuroendocrine systems have an intimate cross-communication that makes possible a satisfactory response to environmental changes. Part of this interaction occurs through cytokines and steroid hormones. The last step of this cross-talk is the molecular level. As a model of interaction, this review focuses on the gp130 cytokine family. These cytokines, as well as their receptors, are expressed in pituitary cells. They regulate hormone production as well as growth of pituitary cells. During acute or chronic inflammation or infection, systemic, hypothalamic and hypophyseal gp130 cytokines act on anterior pituitary cells, integrating the neuroendocrine-immune response. Disruptions of these pathways may lead not only to abnormal growth of pituitary cells but also to immune disorders, for which, based on recent findings, targeting these cytokines might be a novel therapeutic approach. © 2007 The Authors. Fil:Gerez, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Bonfiglio, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Giacomini, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Carbia Nagashima, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Silberstein, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09580670_v92_n5_p801_Gerez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
ciliary neurotrophic factor ciliary neurotrophic factor receptor corticotropin cytokine receptor glycoprotein gp 130 interleukin 11 interleukin 11 receptor interleukin 6 interleukin 6 receptor leukemia inhibitory factor oncostatin M prolactin steroid hormone adenohypophysis cell growth chronic inflammation conference paper corticotropin release cytokine production endocrine system environmental change genetic transduction hormone synthesis human humoral immunity hypophysis cell hypophysis gonad system hypothalamus immune system immunity immunopathology neuroendocrine system nonhuman protein expression protein function protein interaction signal transduction Animals Cytokine Receptor gp130 Cytokines Hormones Humans Neuroimmunomodulation Neurosecretory Systems Signal Transduction |
| spellingShingle |
ciliary neurotrophic factor ciliary neurotrophic factor receptor corticotropin cytokine receptor glycoprotein gp 130 interleukin 11 interleukin 11 receptor interleukin 6 interleukin 6 receptor leukemia inhibitory factor oncostatin M prolactin steroid hormone adenohypophysis cell growth chronic inflammation conference paper corticotropin release cytokine production endocrine system environmental change genetic transduction hormone synthesis human humoral immunity hypophysis cell hypophysis gonad system hypothalamus immune system immunity immunopathology neuroendocrine system nonhuman protein expression protein function protein interaction signal transduction Animals Cytokine Receptor gp130 Cytokines Hormones Humans Neuroimmunomodulation Neurosecretory Systems Signal Transduction Gerez, J. Bonfiglio, J. Sosa, S. Giacomini, D. Acuña, M. Carbia Nagashima, A. Perone, M.J. Silberstein, S. Renner, U. Stalla, G.K. Arzt, E. Molecular transduction mechanisms of cytokine-hormone interactions: Role of gp130 cytokines |
| topic_facet |
ciliary neurotrophic factor ciliary neurotrophic factor receptor corticotropin cytokine receptor glycoprotein gp 130 interleukin 11 interleukin 11 receptor interleukin 6 interleukin 6 receptor leukemia inhibitory factor oncostatin M prolactin steroid hormone adenohypophysis cell growth chronic inflammation conference paper corticotropin release cytokine production endocrine system environmental change genetic transduction hormone synthesis human humoral immunity hypophysis cell hypophysis gonad system hypothalamus immune system immunity immunopathology neuroendocrine system nonhuman protein expression protein function protein interaction signal transduction Animals Cytokine Receptor gp130 Cytokines Hormones Humans Neuroimmunomodulation Neurosecretory Systems Signal Transduction |
| description |
Highly sophisticated mechanisms confer on the immune system the capacity to respond with a certain degree of autonomy. However, the final outcome of an immune response depends on the interaction of the immune system with other systems. The immune and neuroendocrine systems have an intimate cross-communication that makes possible a satisfactory response to environmental changes. Part of this interaction occurs through cytokines and steroid hormones. The last step of this cross-talk is the molecular level. As a model of interaction, this review focuses on the gp130 cytokine family. These cytokines, as well as their receptors, are expressed in pituitary cells. They regulate hormone production as well as growth of pituitary cells. During acute or chronic inflammation or infection, systemic, hypothalamic and hypophyseal gp130 cytokines act on anterior pituitary cells, integrating the neuroendocrine-immune response. Disruptions of these pathways may lead not only to abnormal growth of pituitary cells but also to immune disorders, for which, based on recent findings, targeting these cytokines might be a novel therapeutic approach. © 2007 The Authors. |
| format |
JOUR |
| author |
Gerez, J. Bonfiglio, J. Sosa, S. Giacomini, D. Acuña, M. Carbia Nagashima, A. Perone, M.J. Silberstein, S. Renner, U. Stalla, G.K. Arzt, E. |
| author_facet |
Gerez, J. Bonfiglio, J. Sosa, S. Giacomini, D. Acuña, M. Carbia Nagashima, A. Perone, M.J. Silberstein, S. Renner, U. Stalla, G.K. Arzt, E. |
| author_sort |
Gerez, J. |
| title |
Molecular transduction mechanisms of cytokine-hormone interactions: Role of gp130 cytokines |
| title_short |
Molecular transduction mechanisms of cytokine-hormone interactions: Role of gp130 cytokines |
| title_full |
Molecular transduction mechanisms of cytokine-hormone interactions: Role of gp130 cytokines |
| title_fullStr |
Molecular transduction mechanisms of cytokine-hormone interactions: Role of gp130 cytokines |
| title_full_unstemmed |
Molecular transduction mechanisms of cytokine-hormone interactions: Role of gp130 cytokines |
| title_sort |
molecular transduction mechanisms of cytokine-hormone interactions: role of gp130 cytokines |
| url |
http://hdl.handle.net/20.500.12110/paper_09580670_v92_n5_p801_Gerez |
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