Natural inhibitors of blood coagulation and fibrinolysis in patients with lupus anticoagulant
We studied the natural inhibitors (NI) of blood coagulation and fibrinolysis in 50 patients with lupus anticoagulant (LA), in order to identify possible alterations of these NI, that could favour thrombotic manifestations. We found no statistically significant difference in antithrombin III, protein...
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todo:paper_09575235_v3_n6_p765_Kordich2023-10-03T15:52:35Z Natural inhibitors of blood coagulation and fibrinolysis in patients with lupus anticoagulant Kordich, L.C. Forastiero, R.R. Basilotta, E. Porterie, P. Carreras, L.O. antithrombin iii blood clotting inhibitor lupus anticoagulant plasminogen activator inhibitor protein c protein s adolescent adult article child controlled study female human major clinical study male systemic lupus erythematosus thrombosis Abortion, Habitual Adolescent Adult Antiplasmin Antithrombin III Autoimmune Diseases Blood Coagulation Child Comparative Study Female Fibrinolysis Hematologic Diseases Human Infection Lupus Coagulation Inhibitor Lupus Erythematosus, Systemic Male Middle Age Neoplasms Plasminogen Activator Inhibitor 1 Pregnancy Protein C Protein S Thrombosis We studied the natural inhibitors (NI) of blood coagulation and fibrinolysis in 50 patients with lupus anticoagulant (LA), in order to identify possible alterations of these NI, that could favour thrombotic manifestations. We found no statistically significant difference in antithrombin III, protein C and α2-antiplasmin between controls and patients with LA, irrespective of their clinical manifestations. We found an increase of plasminogen activator inhibitor (PAI, P < 0.001) and a decrease of free protein S (PS(f), P < 0.001) and total protein S (PS(t), 0.01 < P < 0.05) in the patients with LA when compared with the control group. We found no difference in the levels of NI between patients with thrombosis (n = 19) and without thrombosis (n = 31) nor between patients with (n = 25) or without thrombosis and/or foetal loss (n = 25). In contrast, we observed a decrease of PS(f) in women with foetal loss (n = 10) as compared with women without foetal loss (n = 22, 0.01 < P < 0.05) and a decrease of PS(f) when comparing 19 patients with systemic lupus erythematosus (SLE) with 31 patients without SLE (0.01 < P < 0.05). These findings show that the patients with LA had several abnormalities in the NI system, but there was no significant association between levels of PAI, PS(f), PS(t) and a history of thrombosis. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09575235_v3_n6_p765_Kordich |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
antithrombin iii blood clotting inhibitor lupus anticoagulant plasminogen activator inhibitor protein c protein s adolescent adult article child controlled study female human major clinical study male systemic lupus erythematosus thrombosis Abortion, Habitual Adolescent Adult Antiplasmin Antithrombin III Autoimmune Diseases Blood Coagulation Child Comparative Study Female Fibrinolysis Hematologic Diseases Human Infection Lupus Coagulation Inhibitor Lupus Erythematosus, Systemic Male Middle Age Neoplasms Plasminogen Activator Inhibitor 1 Pregnancy Protein C Protein S Thrombosis |
spellingShingle |
antithrombin iii blood clotting inhibitor lupus anticoagulant plasminogen activator inhibitor protein c protein s adolescent adult article child controlled study female human major clinical study male systemic lupus erythematosus thrombosis Abortion, Habitual Adolescent Adult Antiplasmin Antithrombin III Autoimmune Diseases Blood Coagulation Child Comparative Study Female Fibrinolysis Hematologic Diseases Human Infection Lupus Coagulation Inhibitor Lupus Erythematosus, Systemic Male Middle Age Neoplasms Plasminogen Activator Inhibitor 1 Pregnancy Protein C Protein S Thrombosis Kordich, L.C. Forastiero, R.R. Basilotta, E. Porterie, P. Carreras, L.O. Natural inhibitors of blood coagulation and fibrinolysis in patients with lupus anticoagulant |
topic_facet |
antithrombin iii blood clotting inhibitor lupus anticoagulant plasminogen activator inhibitor protein c protein s adolescent adult article child controlled study female human major clinical study male systemic lupus erythematosus thrombosis Abortion, Habitual Adolescent Adult Antiplasmin Antithrombin III Autoimmune Diseases Blood Coagulation Child Comparative Study Female Fibrinolysis Hematologic Diseases Human Infection Lupus Coagulation Inhibitor Lupus Erythematosus, Systemic Male Middle Age Neoplasms Plasminogen Activator Inhibitor 1 Pregnancy Protein C Protein S Thrombosis |
description |
We studied the natural inhibitors (NI) of blood coagulation and fibrinolysis in 50 patients with lupus anticoagulant (LA), in order to identify possible alterations of these NI, that could favour thrombotic manifestations. We found no statistically significant difference in antithrombin III, protein C and α2-antiplasmin between controls and patients with LA, irrespective of their clinical manifestations. We found an increase of plasminogen activator inhibitor (PAI, P < 0.001) and a decrease of free protein S (PS(f), P < 0.001) and total protein S (PS(t), 0.01 < P < 0.05) in the patients with LA when compared with the control group. We found no difference in the levels of NI between patients with thrombosis (n = 19) and without thrombosis (n = 31) nor between patients with (n = 25) or without thrombosis and/or foetal loss (n = 25). In contrast, we observed a decrease of PS(f) in women with foetal loss (n = 10) as compared with women without foetal loss (n = 22, 0.01 < P < 0.05) and a decrease of PS(f) when comparing 19 patients with systemic lupus erythematosus (SLE) with 31 patients without SLE (0.01 < P < 0.05). These findings show that the patients with LA had several abnormalities in the NI system, but there was no significant association between levels of PAI, PS(f), PS(t) and a history of thrombosis. |
format |
JOUR |
author |
Kordich, L.C. Forastiero, R.R. Basilotta, E. Porterie, P. Carreras, L.O. |
author_facet |
Kordich, L.C. Forastiero, R.R. Basilotta, E. Porterie, P. Carreras, L.O. |
author_sort |
Kordich, L.C. |
title |
Natural inhibitors of blood coagulation and fibrinolysis in patients with lupus anticoagulant |
title_short |
Natural inhibitors of blood coagulation and fibrinolysis in patients with lupus anticoagulant |
title_full |
Natural inhibitors of blood coagulation and fibrinolysis in patients with lupus anticoagulant |
title_fullStr |
Natural inhibitors of blood coagulation and fibrinolysis in patients with lupus anticoagulant |
title_full_unstemmed |
Natural inhibitors of blood coagulation and fibrinolysis in patients with lupus anticoagulant |
title_sort |
natural inhibitors of blood coagulation and fibrinolysis in patients with lupus anticoagulant |
url |
http://hdl.handle.net/20.500.12110/paper_09575235_v3_n6_p765_Kordich |
work_keys_str_mv |
AT kordichlc naturalinhibitorsofbloodcoagulationandfibrinolysisinpatientswithlupusanticoagulant AT forastierorr naturalinhibitorsofbloodcoagulationandfibrinolysisinpatientswithlupusanticoagulant AT basilottae naturalinhibitorsofbloodcoagulationandfibrinolysisinpatientswithlupusanticoagulant AT porteriep naturalinhibitorsofbloodcoagulationandfibrinolysisinpatientswithlupusanticoagulant AT carreraslo naturalinhibitorsofbloodcoagulationandfibrinolysisinpatientswithlupusanticoagulant |
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