Synthesis and evaluation of N-substituted acridones as antiviral agents against haemorrhagic fever viruses

Background: In the present study, a series of N-substituted acridone derivatives was synthesized and evaluated against two haemorrhagic fever viruses (HFV). Methods: Compounds were tested against Junin virus (JUNV), an arenavirus agent of Argentine haemorrhagic fever, and dengue virus (DENV), a flav...

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Detalles Bibliográficos
Autores principales: Sepúlveda, C.S., Fascio, M.L., Mazzucco, M.B., Docampo Palacios, M.L., Pellón, R.F., García, C.C., D'Accorso, N.B., Damonte, E.B.
Formato: JOUR
Materias:
10 allyl 2 fluor 9(10h) acridone
10 allyl 6 chloro 2 fluor 9(10h) acridone
10 allyl 7 chloro 9(10h) acridone
6 chloro 10 (3 methyl 2 butenyl) 9(10h) acridone
acridone derivative
antivirus agent
animal cell
antiviral activity
Arenavirus
article
controlled study
cytotoxicity
Dengue virus
drug screening
drug structure
drug synthesis
Junin virus
nonhuman
priority journal
serotype
substitution reaction
virogenesis
virus inactivation
virus inhibition
virus strain
animal
cell survival
Cercopithecus
dengue
drug effect
synthesis
Vero cell
virus culture
virus infection
Acridones
Animals
Antiviral Agents
Arenaviridae Infections
Cell Survival
Cercopithecus aethiops
Dengue Hemorrhagic Fever
Dengue Virus
Plaque Assay
Vero Cells
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09563202_v19_n1_p41_Sepulveda
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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