QTL for survival to UV-C radiation in Drosophila melanogaster

Purpose: The aim of this study was to investigate tolerance to UV-C (ultraviolet C, 280-100 nm) radiation in Drosophila melanogaster, implementing a quantitative trait locus (QTL) mapping approach. This is of interest to test for genetic variation in survival to UV (ultraviolet) radiation. Materials...

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Autores principales:	Gomez, F.H., Loeschcke, V., Norry, F.M.
Formato:	JOUR
Materias:	Environmental stress Multiple trait mapping Thermotolerance Ultraviolet radiation allele animal experiment article chromosome 2 Drosophila melanogaster female gene mapping genetic variability genotype heat tolerance male nonhuman Northern Hemisphere priority journal quantitative trait locus radiation dose Southern Hemisphere survival ultraviolet C radiation Animals Dose-Response Relationship, Radiation Quantitative Trait Loci Radiation Dosage Radiation Tolerance Survival Rate Ultraviolet Rays
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_09553002_v89_n7_p583_Gomez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_09553002_v89_n7_p583_Gomez
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spelling	todo:paper_09553002_v89_n7_p583_Gomez2023-10-03T15:51:47Z QTL for survival to UV-C radiation in Drosophila melanogaster Gomez, F.H. Loeschcke, V. Norry, F.M. Environmental stress Multiple trait mapping Thermotolerance Ultraviolet radiation allele animal experiment article chromosome 2 Drosophila melanogaster female gene mapping genetic variability genotype heat tolerance male nonhuman Northern Hemisphere priority journal quantitative trait locus radiation dose Southern Hemisphere survival ultraviolet C radiation Animals Dose-Response Relationship, Radiation Drosophila melanogaster Quantitative Trait Loci Radiation Dosage Radiation Tolerance Survival Rate Ultraviolet Rays Drosophila melanogaster Purpose: The aim of this study was to investigate tolerance to UV-C (ultraviolet C, 280-100 nm) radiation in Drosophila melanogaster, implementing a quantitative trait locus (QTL) mapping approach. This is of interest to test for genetic variation in survival to UV (ultraviolet) radiation. Materials and methods: We performed a QTL scan in D. melanogaster recombinant inbred lines (RIL) constructed from parental stocks derived from a crossing between northern and southern hemisphere populations that segregated substantial genetic variation in thermal resistance in a previous study. Here, two experimental treatments were implemented: Continuous and cyclic UV-C radiation. Results: Significant QTL were detected on all three major chromosomes. Among these, multiple trait composite interval mapping revealed a significant QTL in the pericentromeric region of chromosome 2, a genome region consistently implicated in thermotolerance in previous studies. Conclusions: This study shows substantial genetic variation for UV-C radiation resistance in D. melanogaster, with QTL for survival to UV-C radiation generally overlapping with major thermotolerance QTL. The genetic architecture of UV-C radiation resistance appears to be more complex in continuously irradiated individuals. © 2013 Informa UK, Ltd. Fil:Gomez, F.H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Norry, F.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09553002_v89_n7_p583_Gomez
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Environmental stress Multiple trait mapping Thermotolerance Ultraviolet radiation allele animal experiment article chromosome 2 Drosophila melanogaster female gene mapping genetic variability genotype heat tolerance male nonhuman Northern Hemisphere priority journal quantitative trait locus radiation dose Southern Hemisphere survival ultraviolet C radiation Animals Dose-Response Relationship, Radiation Drosophila melanogaster Quantitative Trait Loci Radiation Dosage Radiation Tolerance Survival Rate Ultraviolet Rays Drosophila melanogaster
spellingShingle	Environmental stress Multiple trait mapping Thermotolerance Ultraviolet radiation allele animal experiment article chromosome 2 Drosophila melanogaster female gene mapping genetic variability genotype heat tolerance male nonhuman Northern Hemisphere priority journal quantitative trait locus radiation dose Southern Hemisphere survival ultraviolet C radiation Animals Dose-Response Relationship, Radiation Drosophila melanogaster Quantitative Trait Loci Radiation Dosage Radiation Tolerance Survival Rate Ultraviolet Rays Drosophila melanogaster Gomez, F.H. Loeschcke, V. Norry, F.M. QTL for survival to UV-C radiation in Drosophila melanogaster
topic_facet	Environmental stress Multiple trait mapping Thermotolerance Ultraviolet radiation allele animal experiment article chromosome 2 Drosophila melanogaster female gene mapping genetic variability genotype heat tolerance male nonhuman Northern Hemisphere priority journal quantitative trait locus radiation dose Southern Hemisphere survival ultraviolet C radiation Animals Dose-Response Relationship, Radiation Drosophila melanogaster Quantitative Trait Loci Radiation Dosage Radiation Tolerance Survival Rate Ultraviolet Rays Drosophila melanogaster
description	Purpose: The aim of this study was to investigate tolerance to UV-C (ultraviolet C, 280-100 nm) radiation in Drosophila melanogaster, implementing a quantitative trait locus (QTL) mapping approach. This is of interest to test for genetic variation in survival to UV (ultraviolet) radiation. Materials and methods: We performed a QTL scan in D. melanogaster recombinant inbred lines (RIL) constructed from parental stocks derived from a crossing between northern and southern hemisphere populations that segregated substantial genetic variation in thermal resistance in a previous study. Here, two experimental treatments were implemented: Continuous and cyclic UV-C radiation. Results: Significant QTL were detected on all three major chromosomes. Among these, multiple trait composite interval mapping revealed a significant QTL in the pericentromeric region of chromosome 2, a genome region consistently implicated in thermotolerance in previous studies. Conclusions: This study shows substantial genetic variation for UV-C radiation resistance in D. melanogaster, with QTL for survival to UV-C radiation generally overlapping with major thermotolerance QTL. The genetic architecture of UV-C radiation resistance appears to be more complex in continuously irradiated individuals. © 2013 Informa UK, Ltd.
format	JOUR
author	Gomez, F.H. Loeschcke, V. Norry, F.M.
author_facet	Gomez, F.H. Loeschcke, V. Norry, F.M.
author_sort	Gomez, F.H.
title	QTL for survival to UV-C radiation in Drosophila melanogaster
title_short	QTL for survival to UV-C radiation in Drosophila melanogaster
title_full	QTL for survival to UV-C radiation in Drosophila melanogaster
title_fullStr	QTL for survival to UV-C radiation in Drosophila melanogaster
title_full_unstemmed	QTL for survival to UV-C radiation in Drosophila melanogaster
title_sort	qtl for survival to uv-c radiation in drosophila melanogaster
url	http://hdl.handle.net/20.500.12110/paper_09553002_v89_n7_p583_Gomez
work_keys_str_mv	AT gomezfh qtlforsurvivaltouvcradiationindrosophilamelanogaster AT loeschckev qtlforsurvivaltouvcradiationindrosophilamelanogaster AT norryfm qtlforsurvivaltouvcradiationindrosophilamelanogaster
_version_	1782028530207424512

QTL for survival to UV-C radiation in Drosophila melanogaster

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