Evolutionarily-conserved role of the NF-κB transcription factor in neural plasticity and memory

NF-κB is an evolutionarily conserved family of transcription factors (TFs) critically involved in basic cellular mechanisms of the immune response, inflammation, development and apoptosis. In spite of the fact that it is expressed in the central nervous system, particularly in areas involved in memo...

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Autores principales: Romano, A., Freudenthal, R., Merlo, E., Routtenberg, A.
Formato: JOUR
Materias:
Gene expression
Long-term memory
Synaptic plasticity
immunoglobulin enhancer binding protein
transcription factor
cell nucleus
gene expression regulation
genetic transcription
invertebrate
knockout mouse
long term memory
mammal
nerve cell plasticity
nonhuman
priority journal
protein function
review
signal transduction
synapse
Animals
Biological Evolution
Evolution
Gene Expression
Humans
Memory
Models, Biological
Neuronal Plasticity
NF-kappa B
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0953816X_v24_n6_p1507_Romano
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_0953816X_v24_n6_p1507_Romano
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spelling todo:paper_0953816X_v24_n6_p1507_Romano2023-10-03T15:51:17Z Evolutionarily-conserved role of the NF-κB transcription factor in neural plasticity and memory Romano, A. Freudenthal, R. Merlo, E. Routtenberg, A. Gene expression Long-term memory Synaptic plasticity immunoglobulin enhancer binding protein transcription factor cell nucleus gene expression regulation genetic transcription invertebrate knockout mouse long term memory mammal nerve cell plasticity nonhuman priority journal protein function review signal transduction synapse Animals Biological Evolution Evolution Gene Expression Humans Memory Models, Biological Neuronal Plasticity NF-kappa B NF-κB is an evolutionarily conserved family of transcription factors (TFs) critically involved in basic cellular mechanisms of the immune response, inflammation, development and apoptosis. In spite of the fact that it is expressed in the central nervous system, particularly in areas involved in memory processing, and is activated by signals such as glutamate and Ca 2+, its role in neural plasticity and memory has only recently become apparent. A surprising feature of this molecule is its presence within the synapse. An increasing number of reports have called attention to the role of this TF in processes that require long-term regulation of the synaptic function underlying memory and neural plasticity. Here we review the evidence regarding a dual role for NF-κB, as both a signalling molecule after its activation at the synapse and a transcriptional regulator upon reaching the nucleus. The specific role of this signal, as well as the general transcriptional mechanism, in the process of memory formation is discussed. Converging lines of evidence summarized here point to a pivotal role for the NF-κB transcription factor as a direct signalling mechanism in the regulation of gene expression involved in long-term memory. © The Authors (2006). Fil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Freudenthal, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Merlo, E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0953816X_v24_n6_p1507_Romano
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Gene expression
Long-term memory
Synaptic plasticity
immunoglobulin enhancer binding protein
transcription factor
cell nucleus
gene expression regulation
genetic transcription
invertebrate
knockout mouse
long term memory
mammal
nerve cell plasticity
nonhuman
priority journal
protein function
review
signal transduction
synapse
Animals
Biological Evolution
Evolution
Gene Expression
Humans
Memory
Models, Biological
Neuronal Plasticity
NF-kappa B
spellingShingle Gene expression
Long-term memory
Synaptic plasticity
immunoglobulin enhancer binding protein
transcription factor
cell nucleus
gene expression regulation
genetic transcription
invertebrate
knockout mouse
long term memory
mammal
nerve cell plasticity
nonhuman
priority journal
protein function
review
signal transduction
synapse
Animals
Biological Evolution
Evolution
Gene Expression
Humans
Memory
Models, Biological
Neuronal Plasticity
NF-kappa B
Romano, A.
Freudenthal, R.
Merlo, E.
Routtenberg, A.
Evolutionarily-conserved role of the NF-κB transcription factor in neural plasticity and memory
topic_facet Gene expression
Long-term memory
Synaptic plasticity
immunoglobulin enhancer binding protein
transcription factor
cell nucleus
gene expression regulation
genetic transcription
invertebrate
knockout mouse
long term memory
mammal
nerve cell plasticity
nonhuman
priority journal
protein function
review
signal transduction
synapse
Animals
Biological Evolution
Evolution
Gene Expression
Humans
Memory
Models, Biological
Neuronal Plasticity
NF-kappa B
description NF-κB is an evolutionarily conserved family of transcription factors (TFs) critically involved in basic cellular mechanisms of the immune response, inflammation, development and apoptosis. In spite of the fact that it is expressed in the central nervous system, particularly in areas involved in memory processing, and is activated by signals such as glutamate and Ca 2+, its role in neural plasticity and memory has only recently become apparent. A surprising feature of this molecule is its presence within the synapse. An increasing number of reports have called attention to the role of this TF in processes that require long-term regulation of the synaptic function underlying memory and neural plasticity. Here we review the evidence regarding a dual role for NF-κB, as both a signalling molecule after its activation at the synapse and a transcriptional regulator upon reaching the nucleus. The specific role of this signal, as well as the general transcriptional mechanism, in the process of memory formation is discussed. Converging lines of evidence summarized here point to a pivotal role for the NF-κB transcription factor as a direct signalling mechanism in the regulation of gene expression involved in long-term memory. © The Authors (2006).
format JOUR
author Romano, A.
Freudenthal, R.
Merlo, E.
Routtenberg, A.
author_facet Romano, A.
Freudenthal, R.
Merlo, E.
Routtenberg, A.
author_sort Romano, A.
title Evolutionarily-conserved role of the NF-κB transcription factor in neural plasticity and memory
title_short Evolutionarily-conserved role of the NF-κB transcription factor in neural plasticity and memory
title_full Evolutionarily-conserved role of the NF-κB transcription factor in neural plasticity and memory
title_fullStr Evolutionarily-conserved role of the NF-κB transcription factor in neural plasticity and memory
title_full_unstemmed Evolutionarily-conserved role of the NF-κB transcription factor in neural plasticity and memory
title_sort evolutionarily-conserved role of the nf-κb transcription factor in neural plasticity and memory
url http://hdl.handle.net/20.500.12110/paper_0953816X_v24_n6_p1507_Romano
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AT routtenberga evolutionarilyconservedroleofthenfkbtranscriptionfactorinneuralplasticityandmemory
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