Morphine diminishes the constancy of spontaneous uterine contractions, antagonizes the positive inotropic effects of prostaglandin E2, but not of prostaglandin F2α and inhibits prostaglandin E and F outputs from the uterus of ovariectomized rats
The effects of morphine on the constancy of spontaneous contractions (isometric developed tension = IDT and contractile frequency = CF), in uterine strips isolated from ovariectomized rats and the influence of naloxone, were explored. The inotropic responses to added prostaglandins (PGs) E2 and F2α...
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todo:paper_09523278_v34_n3_p147_Faletti2023-10-03T15:50:44Z Morphine diminishes the constancy of spontaneous uterine contractions, antagonizes the positive inotropic effects of prostaglandin E2, but not of prostaglandin F2α and inhibits prostaglandin E and F outputs from the uterus of ovariectomized rats Faletti, A. Chaud, M.A. Gimeno, M.A.F. Gimeno, A.L. morphine naloxone prostaglandin e2 prostaglandin f2 alpha animal experiment controlled study female nonhuman ovariectomy priority journal rat uterus uterus contraction Animal Dinoprost Dinoprostone Female Morphine Naloxone Ovariectomy Prostaglandins E Prostaglandins F Rats Rats, Inbred Strains Stimulation, Chemical Uterine Contraction Uterus The effects of morphine on the constancy of spontaneous contractions (isometric developed tension = IDT and contractile frequency = CF), in uterine strips isolated from ovariectomized rats and the influence of naloxone, were explored. The inotropic responses to added prostaglandins (PGs) E2 and F2α and the influences of morphine and of morphine in the presence of naloxone on PG actions, were also determined. Moreover, the synthesis and outputs of PGs E and F from uteri and the effects of morphine alone and of morphine plus naloxone, were studied. Morphine (10-6 M) significantly depressed uterine constancy of IDT during the first hours following delivery, but its action on CF did not differ from controls. Naloxone, neither at 10-8 M nor at 10-6 M, altered the negative inotropoic influence of morphine on IDT. Exogenous PGs E2 and F2α, stimulated uterine inotropism in a concentration-dependent fashion. Morphine altered dose-response curves for exogenous PGE2, evoking a parallel surmountable shift to the right, but did not affect the inotropic action of added PGF2α. This antagonistic effect of the opioid was not altered by preincubation with naloxone. Basal synthesis and outputs of PGs E and F in uteri from ovariectomized rats were significantly depressed by morphine (10-6 M) but not altered by incubating tissues with morphine in presence of naloxone. Results are discussed in terms of a presumptive dual action of morphine on uterine motility, i.e., antagonizing PGE2 receptors and inhibiting the synthesis of some PGs by the uterus. These influences of morphine do not appear to be subserved by the activation of μ opioid receptors. Moreover, the possibility that endogenous opioids could play a relevant role modulating uterine PG influences, is also discussed. © 1988. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09523278_v34_n3_p147_Faletti |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
morphine naloxone prostaglandin e2 prostaglandin f2 alpha animal experiment controlled study female nonhuman ovariectomy priority journal rat uterus uterus contraction Animal Dinoprost Dinoprostone Female Morphine Naloxone Ovariectomy Prostaglandins E Prostaglandins F Rats Rats, Inbred Strains Stimulation, Chemical Uterine Contraction Uterus |
| spellingShingle |
morphine naloxone prostaglandin e2 prostaglandin f2 alpha animal experiment controlled study female nonhuman ovariectomy priority journal rat uterus uterus contraction Animal Dinoprost Dinoprostone Female Morphine Naloxone Ovariectomy Prostaglandins E Prostaglandins F Rats Rats, Inbred Strains Stimulation, Chemical Uterine Contraction Uterus Faletti, A. Chaud, M.A. Gimeno, M.A.F. Gimeno, A.L. Morphine diminishes the constancy of spontaneous uterine contractions, antagonizes the positive inotropic effects of prostaglandin E2, but not of prostaglandin F2α and inhibits prostaglandin E and F outputs from the uterus of ovariectomized rats |
| topic_facet |
morphine naloxone prostaglandin e2 prostaglandin f2 alpha animal experiment controlled study female nonhuman ovariectomy priority journal rat uterus uterus contraction Animal Dinoprost Dinoprostone Female Morphine Naloxone Ovariectomy Prostaglandins E Prostaglandins F Rats Rats, Inbred Strains Stimulation, Chemical Uterine Contraction Uterus |
| description |
The effects of morphine on the constancy of spontaneous contractions (isometric developed tension = IDT and contractile frequency = CF), in uterine strips isolated from ovariectomized rats and the influence of naloxone, were explored. The inotropic responses to added prostaglandins (PGs) E2 and F2α and the influences of morphine and of morphine in the presence of naloxone on PG actions, were also determined. Moreover, the synthesis and outputs of PGs E and F from uteri and the effects of morphine alone and of morphine plus naloxone, were studied. Morphine (10-6 M) significantly depressed uterine constancy of IDT during the first hours following delivery, but its action on CF did not differ from controls. Naloxone, neither at 10-8 M nor at 10-6 M, altered the negative inotropoic influence of morphine on IDT. Exogenous PGs E2 and F2α, stimulated uterine inotropism in a concentration-dependent fashion. Morphine altered dose-response curves for exogenous PGE2, evoking a parallel surmountable shift to the right, but did not affect the inotropic action of added PGF2α. This antagonistic effect of the opioid was not altered by preincubation with naloxone. Basal synthesis and outputs of PGs E and F in uteri from ovariectomized rats were significantly depressed by morphine (10-6 M) but not altered by incubating tissues with morphine in presence of naloxone. Results are discussed in terms of a presumptive dual action of morphine on uterine motility, i.e., antagonizing PGE2 receptors and inhibiting the synthesis of some PGs by the uterus. These influences of morphine do not appear to be subserved by the activation of μ opioid receptors. Moreover, the possibility that endogenous opioids could play a relevant role modulating uterine PG influences, is also discussed. © 1988. |
| format |
JOUR |
| author |
Faletti, A. Chaud, M.A. Gimeno, M.A.F. Gimeno, A.L. |
| author_facet |
Faletti, A. Chaud, M.A. Gimeno, M.A.F. Gimeno, A.L. |
| author_sort |
Faletti, A. |
| title |
Morphine diminishes the constancy of spontaneous uterine contractions, antagonizes the positive inotropic effects of prostaglandin E2, but not of prostaglandin F2α and inhibits prostaglandin E and F outputs from the uterus of ovariectomized rats |
| title_short |
Morphine diminishes the constancy of spontaneous uterine contractions, antagonizes the positive inotropic effects of prostaglandin E2, but not of prostaglandin F2α and inhibits prostaglandin E and F outputs from the uterus of ovariectomized rats |
| title_full |
Morphine diminishes the constancy of spontaneous uterine contractions, antagonizes the positive inotropic effects of prostaglandin E2, but not of prostaglandin F2α and inhibits prostaglandin E and F outputs from the uterus of ovariectomized rats |
| title_fullStr |
Morphine diminishes the constancy of spontaneous uterine contractions, antagonizes the positive inotropic effects of prostaglandin E2, but not of prostaglandin F2α and inhibits prostaglandin E and F outputs from the uterus of ovariectomized rats |
| title_full_unstemmed |
Morphine diminishes the constancy of spontaneous uterine contractions, antagonizes the positive inotropic effects of prostaglandin E2, but not of prostaglandin F2α and inhibits prostaglandin E and F outputs from the uterus of ovariectomized rats |
| title_sort |
morphine diminishes the constancy of spontaneous uterine contractions, antagonizes the positive inotropic effects of prostaglandin e2, but not of prostaglandin f2α and inhibits prostaglandin e and f outputs from the uterus of ovariectomized rats |
| url |
http://hdl.handle.net/20.500.12110/paper_09523278_v34_n3_p147_Faletti |
| work_keys_str_mv |
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