ent-Kaur-16-en-19-oic acid, a KB cells cytotoxic diterpenoid from Elaeoselinum foetidum

Toxic and cytotoxic activities of the toxic plant Elaeoselinum foetidum (Apiaceae) were evaluated using the brine shrimp toxicity (BST) and KB cell cytotoxicity assays. The active chloroform extract was subjected to a bioactivity-directed fractionation, monitored by the BST assay, that led to the is...

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Autores principales: Mongelli, E., Pomilio, A.B., Bustamante Sánchez, J., Guerra, F.M., Martínez Massanet, G.
Formato: JOUR
Materias:
Brine shrimp test
Cytotoxicity
Elaeoselinum foetidum
Ent-kaur-16-en-19-oic acid
KB cells
chloroform
colchicine
diterpenoid
DNA
Elaeoselinum foetidum extract
kaurenoic acid
methyl green
plant extract
sodium chloride
unclassified drug
Apiales
article
bioassay
cell strain KB
chromatography
controlled study
drug cytotoxicity
drug DNA interaction
drug exposure
drug isolation
drug potency
drug structure
fractionation
high performance liquid chromatography
higher plant
human
human cell
IC 50
LC 50
nonhuman
shrimp
structure analysis
toxicity testing
Animals
Antineoplastic Agents, Phytogenic
Apiaceae
Artemia
Carcinoma, Squamous Cell
Cytotoxins
Diterpenes
Humans
Inhibitory Concentration 50
KB Cells
Lethal Dose 50
Molecular Structure
Anostraca
Decapoda (Crustacea)
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0951418X_v16_n4_p387_Mongelli
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling todo:paper_0951418X_v16_n4_p387_Mongelli2023-10-03T15:50:37Z ent-Kaur-16-en-19-oic acid, a KB cells cytotoxic diterpenoid from Elaeoselinum foetidum Mongelli, E. Pomilio, A.B. Bustamante Sánchez, J. Guerra, F.M. Martínez Massanet, G. Brine shrimp test Cytotoxicity Elaeoselinum foetidum Ent-kaur-16-en-19-oic acid KB cells chloroform colchicine diterpenoid DNA Elaeoselinum foetidum extract kaurenoic acid methyl green plant extract sodium chloride unclassified drug Apiales article bioassay cell strain KB chromatography controlled study drug cytotoxicity drug DNA interaction drug exposure drug isolation drug potency drug structure Elaeoselinum foetidum fractionation high performance liquid chromatography higher plant human human cell IC 50 LC 50 nonhuman shrimp structure analysis toxicity testing Animals Antineoplastic Agents, Phytogenic Apiaceae Artemia Carcinoma, Squamous Cell Cytotoxins Diterpenes Humans Inhibitory Concentration 50 KB Cells Lethal Dose 50 Molecular Structure Anostraca Apiaceae Decapoda (Crustacea) Toxic and cytotoxic activities of the toxic plant Elaeoselinum foetidum (Apiaceae) were evaluated using the brine shrimp toxicity (BST) and KB cell cytotoxicity assays. The active chloroform extract was subjected to a bioactivity-directed fractionation, monitored by the BST assay, that led to the isolation of the diterpenoid ent-kaur-16-en-19-oic acid. This compound was potent against the brine shrimp (LC50 = 4.8 μg/mL) and KB cells (IC50 = 1.6 μg/mL). Copyright © 2002 John Wiley & Sons, Ltd. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0951418X_v16_n4_p387_Mongelli
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Brine shrimp test
Cytotoxicity
Elaeoselinum foetidum
Ent-kaur-16-en-19-oic acid
KB cells
chloroform
colchicine
diterpenoid
DNA
Elaeoselinum foetidum extract
kaurenoic acid
methyl green
plant extract
sodium chloride
unclassified drug
Apiales
article
bioassay
cell strain KB
chromatography
controlled study
drug cytotoxicity
drug DNA interaction
drug exposure
drug isolation
drug potency
drug structure
Elaeoselinum foetidum
fractionation
high performance liquid chromatography
higher plant
human
human cell
IC 50
LC 50
nonhuman
shrimp
structure analysis
toxicity testing
Animals
Antineoplastic Agents, Phytogenic
Apiaceae
Artemia
Carcinoma, Squamous Cell
Cytotoxins
Diterpenes
Humans
Inhibitory Concentration 50
KB Cells
Lethal Dose 50
Molecular Structure
Anostraca
Apiaceae
Decapoda (Crustacea)
spellingShingle Brine shrimp test
Cytotoxicity
Elaeoselinum foetidum
Ent-kaur-16-en-19-oic acid
KB cells
chloroform
colchicine
diterpenoid
DNA
Elaeoselinum foetidum extract
kaurenoic acid
methyl green
plant extract
sodium chloride
unclassified drug
Apiales
article
bioassay
cell strain KB
chromatography
controlled study
drug cytotoxicity
drug DNA interaction
drug exposure
drug isolation
drug potency
drug structure
Elaeoselinum foetidum
fractionation
high performance liquid chromatography
higher plant
human
human cell
IC 50
LC 50
nonhuman
shrimp
structure analysis
toxicity testing
Animals
Antineoplastic Agents, Phytogenic
Apiaceae
Artemia
Carcinoma, Squamous Cell
Cytotoxins
Diterpenes
Humans
Inhibitory Concentration 50
KB Cells
Lethal Dose 50
Molecular Structure
Anostraca
Apiaceae
Decapoda (Crustacea)
Mongelli, E.
Pomilio, A.B.
Bustamante Sánchez, J.
Guerra, F.M.
Martínez Massanet, G.
ent-Kaur-16-en-19-oic acid, a KB cells cytotoxic diterpenoid from Elaeoselinum foetidum
topic_facet Brine shrimp test
Cytotoxicity
Elaeoselinum foetidum
Ent-kaur-16-en-19-oic acid
KB cells
chloroform
colchicine
diterpenoid
DNA
Elaeoselinum foetidum extract
kaurenoic acid
methyl green
plant extract
sodium chloride
unclassified drug
Apiales
article
bioassay
cell strain KB
chromatography
controlled study
drug cytotoxicity
drug DNA interaction
drug exposure
drug isolation
drug potency
drug structure
Elaeoselinum foetidum
fractionation
high performance liquid chromatography
higher plant
human
human cell
IC 50
LC 50
nonhuman
shrimp
structure analysis
toxicity testing
Animals
Antineoplastic Agents, Phytogenic
Apiaceae
Artemia
Carcinoma, Squamous Cell
Cytotoxins
Diterpenes
Humans
Inhibitory Concentration 50
KB Cells
Lethal Dose 50
Molecular Structure
Anostraca
Apiaceae
Decapoda (Crustacea)
description Toxic and cytotoxic activities of the toxic plant Elaeoselinum foetidum (Apiaceae) were evaluated using the brine shrimp toxicity (BST) and KB cell cytotoxicity assays. The active chloroform extract was subjected to a bioactivity-directed fractionation, monitored by the BST assay, that led to the isolation of the diterpenoid ent-kaur-16-en-19-oic acid. This compound was potent against the brine shrimp (LC50 = 4.8 μg/mL) and KB cells (IC50 = 1.6 μg/mL). Copyright © 2002 John Wiley & Sons, Ltd.
format JOUR
author Mongelli, E.
Pomilio, A.B.
Bustamante Sánchez, J.
Guerra, F.M.
Martínez Massanet, G.
author_facet Mongelli, E.
Pomilio, A.B.
Bustamante Sánchez, J.
Guerra, F.M.
Martínez Massanet, G.
author_sort Mongelli, E.
title ent-Kaur-16-en-19-oic acid, a KB cells cytotoxic diterpenoid from Elaeoselinum foetidum
title_short ent-Kaur-16-en-19-oic acid, a KB cells cytotoxic diterpenoid from Elaeoselinum foetidum
title_full ent-Kaur-16-en-19-oic acid, a KB cells cytotoxic diterpenoid from Elaeoselinum foetidum
title_fullStr ent-Kaur-16-en-19-oic acid, a KB cells cytotoxic diterpenoid from Elaeoselinum foetidum
title_full_unstemmed ent-Kaur-16-en-19-oic acid, a KB cells cytotoxic diterpenoid from Elaeoselinum foetidum
title_sort ent-kaur-16-en-19-oic acid, a kb cells cytotoxic diterpenoid from elaeoselinum foetidum
url http://hdl.handle.net/20.500.12110/paper_0951418X_v16_n4_p387_Mongelli
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AT pomilioab entkaur16en19oicacidakbcellscytotoxicditerpenoidfromelaeoselinumfoetidum
AT bustamantesanchezj entkaur16en19oicacidakbcellscytotoxicditerpenoidfromelaeoselinumfoetidum
AT guerrafm entkaur16en19oicacidakbcellscytotoxicditerpenoidfromelaeoselinumfoetidum
AT martinezmassanetg entkaur16en19oicacidakbcellscytotoxicditerpenoidfromelaeoselinumfoetidum
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