Triterpenic acids and flavonoids from Satureja parvifolia, evaluation of their antiprotozoal activity
Bioassay-guided fractionation of a Satureja parvifolia MeOH extract led to the isolation of eriodictyol, luteolin and ursolic and oleanolic acids as its active components against Plasmodium falciparum K1. This is the first time these compounds are reported as constituents of S. parvifolia. Ursolic a...
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| Lenguaje: | English |
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_09395075_v61_n3-4_p189_VanBaren |
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todo:paper_09395075_v61_n3-4_p189_VanBaren2023-10-03T15:48:52Z Triterpenic acids and flavonoids from Satureja parvifolia, evaluation of their antiprotozoal activity Van Baren, C. Anao, I. Lira, P.D.L. Debenedetti, S. Houghton, P. Croft, S. Martino, V. Antiprotozoal Compounds Satureja parvifolia antiprotozoal agent chloroquine eriodictyol flavanone derivative flavonoid methanol oleanolic acid triterpene ursolic acid animal article cell survival chemistry drug effect isolation and purification mass fragmentography phytotherapy plant Plasmodium falciparum savory Animals Antiprotozoal Agents Cell Survival Chloroquine Flavanones Flavonoids Gas Chromatography-Mass Spectrometry Methanol Oleanolic Acid Phytotherapy Plant Components, Aerial Plasmodium falciparum Satureja Triterpenes Mammalia Plasmodium falciparum Satureja Trypanosoma brucei rhodesiense Bioassay-guided fractionation of a Satureja parvifolia MeOH extract led to the isolation of eriodictyol, luteolin and ursolic and oleanolic acids as its active components against Plasmodium falciparum K1. This is the first time these compounds are reported as constituents of S. parvifolia. Ursolic acid showed an IC 50 of 4.9 μg/ml, luteolin 6.4 μg/ml, oleanolic acid 9.3 μg/ml and eriodictyol 17.2 μg/ml. Antiplasmodial activity of eriodictyol and luteolin is reported here for the first time. Besides, the four compounds showed activity against P. falciparum 3D7 strain and Trypanosoma brucei rhodesiense. Eriodictyol showed moderate activity on all the parasites but was the most selective compound as a result of its rather low cytotoxicity (IC 50 174.2 μg/ml) on the mammalian KB cell line. © 2006 Verlag der Zeitschrift für Naturforschung. JOUR English info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09395075_v61_n3-4_p189_VanBaren |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| language |
English |
| orig_language_str_mv |
English |
| topic |
Antiprotozoal Compounds Satureja parvifolia antiprotozoal agent chloroquine eriodictyol flavanone derivative flavonoid methanol oleanolic acid triterpene ursolic acid animal article cell survival chemistry drug effect isolation and purification mass fragmentography phytotherapy plant Plasmodium falciparum savory Animals Antiprotozoal Agents Cell Survival Chloroquine Flavanones Flavonoids Gas Chromatography-Mass Spectrometry Methanol Oleanolic Acid Phytotherapy Plant Components, Aerial Plasmodium falciparum Satureja Triterpenes Mammalia Plasmodium falciparum Satureja Trypanosoma brucei rhodesiense |
| spellingShingle |
Antiprotozoal Compounds Satureja parvifolia antiprotozoal agent chloroquine eriodictyol flavanone derivative flavonoid methanol oleanolic acid triterpene ursolic acid animal article cell survival chemistry drug effect isolation and purification mass fragmentography phytotherapy plant Plasmodium falciparum savory Animals Antiprotozoal Agents Cell Survival Chloroquine Flavanones Flavonoids Gas Chromatography-Mass Spectrometry Methanol Oleanolic Acid Phytotherapy Plant Components, Aerial Plasmodium falciparum Satureja Triterpenes Mammalia Plasmodium falciparum Satureja Trypanosoma brucei rhodesiense Van Baren, C. Anao, I. Lira, P.D.L. Debenedetti, S. Houghton, P. Croft, S. Martino, V. Triterpenic acids and flavonoids from Satureja parvifolia, evaluation of their antiprotozoal activity |
| topic_facet |
Antiprotozoal Compounds Satureja parvifolia antiprotozoal agent chloroquine eriodictyol flavanone derivative flavonoid methanol oleanolic acid triterpene ursolic acid animal article cell survival chemistry drug effect isolation and purification mass fragmentography phytotherapy plant Plasmodium falciparum savory Animals Antiprotozoal Agents Cell Survival Chloroquine Flavanones Flavonoids Gas Chromatography-Mass Spectrometry Methanol Oleanolic Acid Phytotherapy Plant Components, Aerial Plasmodium falciparum Satureja Triterpenes Mammalia Plasmodium falciparum Satureja Trypanosoma brucei rhodesiense |
| description |
Bioassay-guided fractionation of a Satureja parvifolia MeOH extract led to the isolation of eriodictyol, luteolin and ursolic and oleanolic acids as its active components against Plasmodium falciparum K1. This is the first time these compounds are reported as constituents of S. parvifolia. Ursolic acid showed an IC 50 of 4.9 μg/ml, luteolin 6.4 μg/ml, oleanolic acid 9.3 μg/ml and eriodictyol 17.2 μg/ml. Antiplasmodial activity of eriodictyol and luteolin is reported here for the first time. Besides, the four compounds showed activity against P. falciparum 3D7 strain and Trypanosoma brucei rhodesiense. Eriodictyol showed moderate activity on all the parasites but was the most selective compound as a result of its rather low cytotoxicity (IC 50 174.2 μg/ml) on the mammalian KB cell line. © 2006 Verlag der Zeitschrift für Naturforschung. |
| format |
JOUR |
| author |
Van Baren, C. Anao, I. Lira, P.D.L. Debenedetti, S. Houghton, P. Croft, S. Martino, V. |
| author_facet |
Van Baren, C. Anao, I. Lira, P.D.L. Debenedetti, S. Houghton, P. Croft, S. Martino, V. |
| author_sort |
Van Baren, C. |
| title |
Triterpenic acids and flavonoids from Satureja parvifolia, evaluation of their antiprotozoal activity |
| title_short |
Triterpenic acids and flavonoids from Satureja parvifolia, evaluation of their antiprotozoal activity |
| title_full |
Triterpenic acids and flavonoids from Satureja parvifolia, evaluation of their antiprotozoal activity |
| title_fullStr |
Triterpenic acids and flavonoids from Satureja parvifolia, evaluation of their antiprotozoal activity |
| title_full_unstemmed |
Triterpenic acids and flavonoids from Satureja parvifolia, evaluation of their antiprotozoal activity |
| title_sort |
triterpenic acids and flavonoids from satureja parvifolia, evaluation of their antiprotozoal activity |
| url |
http://hdl.handle.net/20.500.12110/paper_09395075_v61_n3-4_p189_VanBaren |
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