Biosynthesis of Withanolides in Acnistus breviflorus Chemical Degradation of 14C-Labelled Jaborosalactone A and Withaferin A
Administration of [2-14C]mevalonolactone to excised leaves of Acnistus breviflorus produced labelled withaferin A and jaborosalactone A. Degradation of the labelled withanolides allowed isolation of C-26. and in the case of withaferin A of C-1, both derived from C-2 of mevalonolactone. The relative...
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| Autores principales: | , , , |
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| Formato: | JOUR |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_09320776_v42_n11_p1471_Monteagudo |
| Aporte de: |
| Sumario: | Administration of [2-14C]mevalonolactone to excised leaves of Acnistus breviflorus produced labelled withaferin A and jaborosalactone A. Degradation of the labelled withanolides allowed isolation of C-26. and in the case of withaferin A of C-1, both derived from C-2 of mevalonolactone. The relative specific activity of these carbon atoms was consistent with our previous results indicating the partial cleavage of the side chain of a sterol precursor in the biosynthetic process leading to the withanolides. © 1987, Walter de Gruyter. All rights reserved. |
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